Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/70222 |
Resumo: | Apoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal and integumentary systems. The role of apoptosis in post-mitotic tissues, such as skeletal muscle, is less well defined, but several lines of evidence suggest that it occurs in both myofiber and other interstitial muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as caspase-independent pathways have been implicated, and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required to clarify the different causes of skeletal muscle mass loss. In this review, it was also speculated that apoptosis is a normal regulatory process that the myofiber can use to reduce the number of nuclear domains, thus ensuring optimal cell functions according to the mechanical load imposed on the muscle. ©FUNPEC-RP. |
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Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophyApoptosisAtrophySkeletal musclecaspaseapoptosiscell functioncell proliferationcell typeconference paperepithelium cellhumanintestine epithelium cellmuscle atrophymuscle cellmuscle functionmuscle massphenotypeskeletal muscleApoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal and integumentary systems. The role of apoptosis in post-mitotic tissues, such as skeletal muscle, is less well defined, but several lines of evidence suggest that it occurs in both myofiber and other interstitial muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as caspase-independent pathways have been implicated, and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required to clarify the different causes of skeletal muscle mass loss. In this review, it was also speculated that apoptosis is a normal regulatory process that the myofiber can use to reduce the number of nuclear domains, thus ensuring optimal cell functions according to the mechanical load imposed on the muscle. ©FUNPEC-RP.Departamento de Educação Física Laboratório de Biodinâmica Universidade Estadual Paulista, Rio Claro, SPCIAFEL Faculdade de Desporto Universidade do Porto, PortoDepartamento de Educação Física Laboratório de Biodinâmica Universidade Estadual Paulista, Rio Claro, SPUniversidade Estadual Paulista (Unesp)Universidade do PortoVoltarelli, F. A. [UNESP]Duarte, J. A RMello, M. A R [UNESP]2014-05-27T11:22:45Z2014-05-27T11:22:45Z2007-12-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject1123-1130Genetics and Molecular Research, v. 6, n. 4, p. 1123-1130, 2007.1676-5680http://hdl.handle.net/11449/702222-s2.0-37349113792Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Research0,439info:eu-repo/semantics/openAccess2021-10-23T21:41:41Zoai:repositorio.unesp.br:11449/70222Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:57:32.921744Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
title |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
spellingShingle |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy Voltarelli, F. A. [UNESP] Apoptosis Atrophy Skeletal muscle caspase apoptosis cell function cell proliferation cell type conference paper epithelium cell human intestine epithelium cell muscle atrophy muscle cell muscle function muscle mass phenotype skeletal muscle |
title_short |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
title_full |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
title_fullStr |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
title_full_unstemmed |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
title_sort |
Cellular and molecular mechanisms of apoptosis in skeletal muscle atrophy |
author |
Voltarelli, F. A. [UNESP] |
author_facet |
Voltarelli, F. A. [UNESP] Duarte, J. A R Mello, M. A R [UNESP] |
author_role |
author |
author2 |
Duarte, J. A R Mello, M. A R [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade do Porto |
dc.contributor.author.fl_str_mv |
Voltarelli, F. A. [UNESP] Duarte, J. A R Mello, M. A R [UNESP] |
dc.subject.por.fl_str_mv |
Apoptosis Atrophy Skeletal muscle caspase apoptosis cell function cell proliferation cell type conference paper epithelium cell human intestine epithelium cell muscle atrophy muscle cell muscle function muscle mass phenotype skeletal muscle |
topic |
Apoptosis Atrophy Skeletal muscle caspase apoptosis cell function cell proliferation cell type conference paper epithelium cell human intestine epithelium cell muscle atrophy muscle cell muscle function muscle mass phenotype skeletal muscle |
description |
Apoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal and integumentary systems. The role of apoptosis in post-mitotic tissues, such as skeletal muscle, is less well defined, but several lines of evidence suggest that it occurs in both myofiber and other interstitial muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as caspase-independent pathways have been implicated, and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required to clarify the different causes of skeletal muscle mass loss. In this review, it was also speculated that apoptosis is a normal regulatory process that the myofiber can use to reduce the number of nuclear domains, thus ensuring optimal cell functions according to the mechanical load imposed on the muscle. ©FUNPEC-RP. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-28 2014-05-27T11:22:45Z 2014-05-27T11:22:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Genetics and Molecular Research, v. 6, n. 4, p. 1123-1130, 2007. 1676-5680 http://hdl.handle.net/11449/70222 2-s2.0-37349113792 |
identifier_str_mv |
Genetics and Molecular Research, v. 6, n. 4, p. 1123-1130, 2007. 1676-5680 2-s2.0-37349113792 |
url |
http://hdl.handle.net/11449/70222 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and Molecular Research 0,439 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1123-1130 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128586755866624 |