Período de carência de medicamento veterinário em tecidos comestíveis de origem animal

• Autor(a) principal: Guiraldelli, Giulia Gumiero
• Data de Publicação: 2023
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/238976
• topic: Medicamento veterinário; Resíduos; Período de carência; Veterinary drugs; Residues; Withdrawal period

The use of veterinary drugs in production animals may generate residues in their tissues, which can be harmful to human health. In order to ensure that the concentration of these residues does not exceed the Maximum Residue Limit (MRL), which is a safe limit, it is necessary to establish a withdrawal period, which can be defined as the waiting period of time so that an animal can be slaughtered after being treated with a veterinary drug. The calculation of this period takes place through the execution of clinical studies, the marker residue depletion studies, within the pharmaceutical company that owns such drug. The estimation of the withdrawal period is normally obtained by the fitting of a simple linear regression model, followed by the calculation of a tolerance limit. There are statistical assumptions that must be met for this method of choice to be used, but this is not always the case. Thus, when it is not possible to use linear regression, an alternative approach is chosen, which, in addition to establishing the withdrawal period at the time when residue concentrations in all tissues of all animals are equal or below the respective MRL, also makes use of a safety interval in order to compensate for the uncertainties inherent in various parameters