Carboxymethyl-botryosphaeran stabilized carbon nanotubes aqueous dispersion: A new platform design for electrochemical sensing of desloratadine

• Autor(a) principal: Salamanca-Neto, Carlos A.R.
• Data de Publicação: 2020
• Outros Autores: Olean-Oliveira, André [UNESP], Scremin, Jessica, Ceravolo, Graziela S., Dekker, Robert F.H., Barbosa-Dekker, Aneli M., Teixeira, Marcos F.S. [UNESP], Sartori, Elen R.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.talanta.2019.120642; http://hdl.handle.net/11449/199802
• topic: Biological sample; Botryosphaeria rhodina MAMB-05; Modified glassy carbon electrode; MWCNTs aqueous dispersion; Pharmaceutical analysis

The polysaccharide carboxymethyl-botryosphaeran (CMB) was used to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in water. This feature was applied in modifying a glassy carbon electrode (GCE) to construct a sensitive voltammetric sensor for the determination of desloratadine (DESL), a tricyclic antihistamine. The morphology and spectroscopic behavior of the sensor were evaluated. The modified sensor was characterized as homogeneous, and presented a higher electroactive area and a lower charge transfer resistance compared to the unmodified GCE. Using linear sweep voltammetry at 25 mV s−1, the developed sensor presented a sensitivity of 1.018 μA L μmol−1 in the linear working range of 1.99–32.9 μmol L−1, with a detection limit of 0.88 μmol L−1 of DESL in 0.10 mol L−1 potassium hydrogen-phosphate solution (pH 8.0). In addition, the sensor showed excellent repeatability with a relative standard deviation of only 1.02% for a sequence of 10 measurements. The sensor was successfully applied in the analysis of pharmaceutical preparations containing DESL, with equivalent results compared to a validated spectrophotometric method at the 95% confidence level. The sensor was also employed in the analysis of a spiked sample of DESL in rat serum.