Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study

Detalhes bibliográficos
Autor(a) principal: Alves, Mariana De Sá [UNESP]
Data de Publicação: 2021
Outros Autores: Fugisaki, Luciana Ruano De Oliveira [UNESP], Dos Santos, Jéssica Diane [UNESP], Scorzoni, Liliana [UNESP], Medina, Rebeca Previate [UNESP], Silva, Dulce Helena Siqueira [UNESP], Junqueira, Juliana Campos [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/mmy/myab008
http://hdl.handle.net/11449/229189
Resumo: Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary: Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.
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spelling Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo studyCandida albicansCandida glabrataCandida kruseiGalleria mellonellaStreptococcus mutansPrevious studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary: Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.Department of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos CamposDepartment of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)Department of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos CamposDepartment of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Alves, Mariana De Sá [UNESP]Fugisaki, Luciana Ruano De Oliveira [UNESP]Dos Santos, Jéssica Diane [UNESP]Scorzoni, Liliana [UNESP]Medina, Rebeca Previate [UNESP]Silva, Dulce Helena Siqueira [UNESP]Junqueira, Juliana Campos [UNESP]2022-04-29T08:30:53Z2022-04-29T08:30:53Z2021-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article744-747http://dx.doi.org/10.1093/mmy/myab008Medical Mycology, v. 59, n. 7, p. 744-747, 2021.1460-27091369-3786http://hdl.handle.net/11449/22918910.1093/mmy/myab0082-s2.0-85110947772Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Mycologyinfo:eu-repo/semantics/openAccess2022-04-29T08:30:53Zoai:repositorio.unesp.br:11449/229189Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:12:35.549306Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
title Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
spellingShingle Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
Alves, Mariana De Sá [UNESP]
Candida albicans
Candida glabrata
Candida krusei
Galleria mellonella
Streptococcus mutans
title_short Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
title_full Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
title_fullStr Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
title_full_unstemmed Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
title_sort Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
author Alves, Mariana De Sá [UNESP]
author_facet Alves, Mariana De Sá [UNESP]
Fugisaki, Luciana Ruano De Oliveira [UNESP]
Dos Santos, Jéssica Diane [UNESP]
Scorzoni, Liliana [UNESP]
Medina, Rebeca Previate [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
Junqueira, Juliana Campos [UNESP]
author_role author
author2 Fugisaki, Luciana Ruano De Oliveira [UNESP]
Dos Santos, Jéssica Diane [UNESP]
Scorzoni, Liliana [UNESP]
Medina, Rebeca Previate [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
Junqueira, Juliana Campos [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Alves, Mariana De Sá [UNESP]
Fugisaki, Luciana Ruano De Oliveira [UNESP]
Dos Santos, Jéssica Diane [UNESP]
Scorzoni, Liliana [UNESP]
Medina, Rebeca Previate [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
Junqueira, Juliana Campos [UNESP]
dc.subject.por.fl_str_mv Candida albicans
Candida glabrata
Candida krusei
Galleria mellonella
Streptococcus mutans
topic Candida albicans
Candida glabrata
Candida krusei
Galleria mellonella
Streptococcus mutans
description Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary: Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-01
2022-04-29T08:30:53Z
2022-04-29T08:30:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/mmy/myab008
Medical Mycology, v. 59, n. 7, p. 744-747, 2021.
1460-2709
1369-3786
http://hdl.handle.net/11449/229189
10.1093/mmy/myab008
2-s2.0-85110947772
url http://dx.doi.org/10.1093/mmy/myab008
http://hdl.handle.net/11449/229189
identifier_str_mv Medical Mycology, v. 59, n. 7, p. 744-747, 2021.
1460-2709
1369-3786
10.1093/mmy/myab008
2-s2.0-85110947772
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Mycology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 744-747
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128332156370944

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