Effects of losartan on ventricular remodeling in experimental infarction in rats
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0066-782X2000001200001 http://hdl.handle.net/11449/26424 |
Resumo: | OBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22%, and NT = 47% (p<0.05). Ventricular mass,(VM/BM, mg/g) was 4.14 ± 0.76 and 3.54±0.48, in the NT and LO groups, respectively (p<0.05). HOP (median) was 4.92 upsilong/mg in the LO and 5.54 upsilong/g in the NT group (p>0.05). The V0/LV values (median) were 0.24 mL/g in group LO and 0.31 mL/g in group NT (p<0.05) compared to NT group. There were no differences between the groups for +dp/dt and -dp/dt parameters. CONCLUSION: 1- The use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration. |
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Effects of losartan on ventricular remodeling in experimental infarction in ratsfibrosisventricular functionangiotensin IIOBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22%, and NT = 47% (p<0.05). Ventricular mass,(VM/BM, mg/g) was 4.14 ± 0.76 and 3.54±0.48, in the NT and LO groups, respectively (p<0.05). HOP (median) was 4.92 upsilong/mg in the LO and 5.54 upsilong/g in the NT group (p>0.05). The V0/LV values (median) were 0.24 mL/g in group LO and 0.31 mL/g in group NT (p<0.05) compared to NT group. There were no differences between the groups for +dp/dt and -dp/dt parameters. CONCLUSION: 1- The use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration.UNESP Faculdade de Medicina de BotucatuUNESP Faculdade de Medicina de BotucatuSociedade Brasileira de Cardiologia (SBC)Universidade Estadual Paulista (Unesp)Zornoff, Leonardo Antonio Mamede [UNESP]Matsubara, Luiz Shiguero [UNESP]Matsubara, Beatriz Bojikian [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Spadaro, Joel [UNESP]2014-05-20T15:07:14Z2014-05-20T15:07:14Z2000-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article465-470application/pdfhttp://dx.doi.org/10.1590/S0066-782X2000001200001Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 6, p. 465-470, 2000.0066-782Xhttp://hdl.handle.net/11449/2642410.1590/S0066-782X2000001200001S0066-782X20000012000012-s2.0-0041347620S0066-782X2000001200001.pdf630983513799876669909771223407955016839015394547SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-01-21T06:23:41Zoai:repositorio.unesp.br:11449/26424Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-21T06:23:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
title |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
spellingShingle |
Effects of losartan on ventricular remodeling in experimental infarction in rats Zornoff, Leonardo Antonio Mamede [UNESP] fibrosis ventricular function angiotensin II |
title_short |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
title_full |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
title_fullStr |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
title_full_unstemmed |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
title_sort |
Effects of losartan on ventricular remodeling in experimental infarction in rats |
author |
Zornoff, Leonardo Antonio Mamede [UNESP] |
author_facet |
Zornoff, Leonardo Antonio Mamede [UNESP] Matsubara, Luiz Shiguero [UNESP] Matsubara, Beatriz Bojikian [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Spadaro, Joel [UNESP] |
author_role |
author |
author2 |
Matsubara, Luiz Shiguero [UNESP] Matsubara, Beatriz Bojikian [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Spadaro, Joel [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Zornoff, Leonardo Antonio Mamede [UNESP] Matsubara, Luiz Shiguero [UNESP] Matsubara, Beatriz Bojikian [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Spadaro, Joel [UNESP] |
dc.subject.por.fl_str_mv |
fibrosis ventricular function angiotensin II |
topic |
fibrosis ventricular function angiotensin II |
description |
OBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22%, and NT = 47% (p<0.05). Ventricular mass,(VM/BM, mg/g) was 4.14 ± 0.76 and 3.54±0.48, in the NT and LO groups, respectively (p<0.05). HOP (median) was 4.92 upsilong/mg in the LO and 5.54 upsilong/g in the NT group (p>0.05). The V0/LV values (median) were 0.24 mL/g in group LO and 0.31 mL/g in group NT (p<0.05) compared to NT group. There were no differences between the groups for +dp/dt and -dp/dt parameters. CONCLUSION: 1- The use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-12-01 2014-05-20T15:07:14Z 2014-05-20T15:07:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0066-782X2000001200001 Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 6, p. 465-470, 2000. 0066-782X http://hdl.handle.net/11449/26424 10.1590/S0066-782X2000001200001 S0066-782X2000001200001 2-s2.0-0041347620 S0066-782X2000001200001.pdf 6309835137998766 6990977122340795 5016839015394547 |
url |
http://dx.doi.org/10.1590/S0066-782X2000001200001 http://hdl.handle.net/11449/26424 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 6, p. 465-470, 2000. 0066-782X 10.1590/S0066-782X2000001200001 S0066-782X2000001200001 2-s2.0-0041347620 S0066-782X2000001200001.pdf 6309835137998766 6990977122340795 5016839015394547 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia 1.318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
465-470 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia (SBC) |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia (SBC) |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965684550074368 |