Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00795-016-0142-7 http://hdl.handle.net/11449/173032 |
Resumo: | Lymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index (p < 0.05). This correlation probably does not indicate a poor prognosis for this PLGA, since this is a low metastasizing carcinoma of the salivary glands. Different from other solid tumors, such as breast or prostatic carcinomas, there is no correlation between VEGF-C and LMD in salivary gland tumors, and so these traits are not able to estimate the metastatic risk or the prognosis of these tumors. |
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Repositório Institucional da UNESP |
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Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumorsLymphatic microvessel densityPrognosesProliferative indexSalivary gland tumorsVEGF-CLymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index (p < 0.05). This correlation probably does not indicate a poor prognosis for this PLGA, since this is a low metastasizing carcinoma of the salivary glands. Different from other solid tumors, such as breast or prostatic carcinomas, there is no correlation between VEGF-C and LMD in salivary gland tumors, and so these traits are not able to estimate the metastatic risk or the prognosis of these tumors.Department of Bioscience and Oral Diagnosis Dental School-Institute of Science and Technology (ICT) Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos CamposDepartment of Bioscience and Oral Diagnosis Dental School-Institute of Science and Technology (ICT) Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos CamposUniversidade Estadual Paulista (Unesp)Americo, Márcia Gimenes [UNESP]Marques, Yonara Maria Freire Soares [UNESP]El Abras Ankha, Milagros Del Valle [UNESP]do Prado, Renata Falchete [UNESP]Carvalho, Yasmin Rodarte [UNESP]2018-12-11T17:03:12Z2018-12-11T17:03:12Z2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17-24application/pdfhttp://dx.doi.org/10.1007/s00795-016-0142-7Medical Molecular Morphology, v. 50, n. 1, p. 17-24, 2017.1860-14991860-1480http://hdl.handle.net/11449/17303210.1007/s00795-016-0142-72-s2.0-849716737682-s2.0-84971673768.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Molecular Morphology0,5060,506info:eu-repo/semantics/openAccess2023-12-05T06:20:27Zoai:repositorio.unesp.br:11449/173032Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:34:12.856907Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
title |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
spellingShingle |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors Americo, Márcia Gimenes [UNESP] Lymphatic microvessel density Prognoses Proliferative index Salivary gland tumors VEGF-C |
title_short |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
title_full |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
title_fullStr |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
title_full_unstemmed |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
title_sort |
Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors |
author |
Americo, Márcia Gimenes [UNESP] |
author_facet |
Americo, Márcia Gimenes [UNESP] Marques, Yonara Maria Freire Soares [UNESP] El Abras Ankha, Milagros Del Valle [UNESP] do Prado, Renata Falchete [UNESP] Carvalho, Yasmin Rodarte [UNESP] |
author_role |
author |
author2 |
Marques, Yonara Maria Freire Soares [UNESP] El Abras Ankha, Milagros Del Valle [UNESP] do Prado, Renata Falchete [UNESP] Carvalho, Yasmin Rodarte [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Americo, Márcia Gimenes [UNESP] Marques, Yonara Maria Freire Soares [UNESP] El Abras Ankha, Milagros Del Valle [UNESP] do Prado, Renata Falchete [UNESP] Carvalho, Yasmin Rodarte [UNESP] |
dc.subject.por.fl_str_mv |
Lymphatic microvessel density Prognoses Proliferative index Salivary gland tumors VEGF-C |
topic |
Lymphatic microvessel density Prognoses Proliferative index Salivary gland tumors VEGF-C |
description |
Lymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index (p < 0.05). This correlation probably does not indicate a poor prognosis for this PLGA, since this is a low metastasizing carcinoma of the salivary glands. Different from other solid tumors, such as breast or prostatic carcinomas, there is no correlation between VEGF-C and LMD in salivary gland tumors, and so these traits are not able to estimate the metastatic risk or the prognosis of these tumors. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 2018-12-11T17:03:12Z 2018-12-11T17:03:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00795-016-0142-7 Medical Molecular Morphology, v. 50, n. 1, p. 17-24, 2017. 1860-1499 1860-1480 http://hdl.handle.net/11449/173032 10.1007/s00795-016-0142-7 2-s2.0-84971673768 2-s2.0-84971673768.pdf |
url |
http://dx.doi.org/10.1007/s00795-016-0142-7 http://hdl.handle.net/11449/173032 |
identifier_str_mv |
Medical Molecular Morphology, v. 50, n. 1, p. 17-24, 2017. 1860-1499 1860-1480 10.1007/s00795-016-0142-7 2-s2.0-84971673768 2-s2.0-84971673768.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical Molecular Morphology 0,506 0,506 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17-24 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129088071663616 |