Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/cbin.11665 http://hdl.handle.net/11449/233342 |
Resumo: | The mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17-β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho-STAT3 (P-STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor-α, COX-2, P-STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG. |
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Repositório Institucional da UNESP |
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Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiolendocrine disruptorfemale prostateinflammationmammary glandmorphologyThe mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17-β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho-STAT3 (P-STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor-α, COX-2, P-STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG.Department of Biology Humanities and Exact Sciences Institute of Biosciences São Paulo State University (UNESP)Department of Histology Embriology and Cell Biology Institute of Biological Sciences (ICB III) Federal University of Goiás (UFG)Department of Biology Humanities and Exact Sciences Institute of Biosciences São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Leonel, Ellen Cristina Rivas [UNESP]Ruiz, Thalles Fernando Rocha [UNESP]Bedolo, Carolina Marques [UNESP]Campos, Silvana Gisele Pegorin [UNESP]Taboga, Sebastião Roberto [UNESP]2022-05-01T07:58:48Z2022-05-01T07:58:48Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/cbin.11665Cell Biology International.1095-83551065-6995http://hdl.handle.net/11449/23334210.1002/cbin.116652-s2.0-85111684137Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCell Biology Internationalinfo:eu-repo/semantics/openAccess2022-05-01T07:58:48Zoai:repositorio.unesp.br:11449/233342Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:32:38.458071Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
title |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
spellingShingle |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol Leonel, Ellen Cristina Rivas [UNESP] endocrine disruptor female prostate inflammation mammary gland morphology |
title_short |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
title_full |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
title_fullStr |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
title_full_unstemmed |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
title_sort |
Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol |
author |
Leonel, Ellen Cristina Rivas [UNESP] |
author_facet |
Leonel, Ellen Cristina Rivas [UNESP] Ruiz, Thalles Fernando Rocha [UNESP] Bedolo, Carolina Marques [UNESP] Campos, Silvana Gisele Pegorin [UNESP] Taboga, Sebastião Roberto [UNESP] |
author_role |
author |
author2 |
Ruiz, Thalles Fernando Rocha [UNESP] Bedolo, Carolina Marques [UNESP] Campos, Silvana Gisele Pegorin [UNESP] Taboga, Sebastião Roberto [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Leonel, Ellen Cristina Rivas [UNESP] Ruiz, Thalles Fernando Rocha [UNESP] Bedolo, Carolina Marques [UNESP] Campos, Silvana Gisele Pegorin [UNESP] Taboga, Sebastião Roberto [UNESP] |
dc.subject.por.fl_str_mv |
endocrine disruptor female prostate inflammation mammary gland morphology |
topic |
endocrine disruptor female prostate inflammation mammary gland morphology |
description |
The mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17-β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho-STAT3 (P-STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor-α, COX-2, P-STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T07:58:48Z 2022-05-01T07:58:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/cbin.11665 Cell Biology International. 1095-8355 1065-6995 http://hdl.handle.net/11449/233342 10.1002/cbin.11665 2-s2.0-85111684137 |
url |
http://dx.doi.org/10.1002/cbin.11665 http://hdl.handle.net/11449/233342 |
identifier_str_mv |
Cell Biology International. 1095-8355 1065-6995 10.1002/cbin.11665 2-s2.0-85111684137 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cell Biology International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128823886086144 |