Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center

Detalhes bibliográficos
Autor(a) principal: Bentlin, Maria Regina [UNESP]
Data de Publicação: 2010
Outros Autores: Ferreira, Gabriel Luís [UNESP], de Souza Rugolo, Ligia Maria Suppo [UNESP], Silva, Geraldo Henrique Soares [UNESP], Mondelli, Alessandro Lia [UNESP], Rugolo Júnior, Antonio [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0004-282X2010000600010
http://hdl.handle.net/11449/226213
Resumo: The aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible were excluded. The variables investigated were birth weight, gestational and postnatal age, procedures, hematological and CSF parameters, and complications. Parametric and non-parametric tests were used (statistical value p<0.05). The incidence of meningitis was 0.6% and mortality was 27%. Of the 22 cases, 59% involved Gram-negative bacteria; 36% Gram-positive and 5% fungi. The groups did not differ in relation to birth weight, gestational and postnatal age, procedures or hematological and CSF parameters. Sepsis, convulsions and deaths were frequent in both groups, without statistical difference. Gram-negative cases showed abscesses and higher frequency of ventriculitis and hydrocephaly. Meningitis was infrequent, but presented high mortality and frequent complications.
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spelling Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary centerMeningite neonatal de acordo com diagnóstico microbiológico: Uma década de experiência em centro terciárioCentral nervous systemMeningitisNewbornSepsisThe aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible were excluded. The variables investigated were birth weight, gestational and postnatal age, procedures, hematological and CSF parameters, and complications. Parametric and non-parametric tests were used (statistical value p<0.05). The incidence of meningitis was 0.6% and mortality was 27%. Of the 22 cases, 59% involved Gram-negative bacteria; 36% Gram-positive and 5% fungi. The groups did not differ in relation to birth weight, gestational and postnatal age, procedures or hematological and CSF parameters. Sepsis, convulsions and deaths were frequent in both groups, without statistical difference. Gram-negative cases showed abscesses and higher frequency of ventriculitis and hydrocephaly. Meningitis was infrequent, but presented high mortality and frequent complications.Department of Pediatrics Hospital das Clínicas Botucatu Medical School UNESP, Botucatu SPHospital das Clínicas Botucatu Medical School UNESP, Botucatu SPDepartment of Pediatrics Hospital das Clínicas Botucatu Medical School UNESP, Botucatu SPHospital das Clínicas Botucatu Medical School UNESP, Botucatu SPUniversidade Estadual Paulista (UNESP)Bentlin, Maria Regina [UNESP]Ferreira, Gabriel Luís [UNESP]de Souza Rugolo, Ligia Maria Suppo [UNESP]Silva, Geraldo Henrique Soares [UNESP]Mondelli, Alessandro Lia [UNESP]Rugolo Júnior, Antonio [UNESP]2022-04-28T22:02:10Z2022-04-28T22:02:10Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article882-887http://dx.doi.org/10.1590/S0004-282X2010000600010Arquivos de Neuro-Psiquiatria, v. 68, n. 6, p. 882-887, 2010.1678-42270004-282Xhttp://hdl.handle.net/11449/22621310.1590/S0004-282X20100006000102-s2.0-79251590591Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccess2024-09-03T13:46:51Zoai:repositorio.unesp.br:11449/226213Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:46:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
Meningite neonatal de acordo com diagnóstico microbiológico: Uma década de experiência em centro terciário
title Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
spellingShingle Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
Bentlin, Maria Regina [UNESP]
Central nervous system
Meningitis
Newborn
Sepsis
title_short Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
title_full Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
title_fullStr Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
title_full_unstemmed Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
title_sort Neonatal meningitis according to the microbiological diagnosis: A decade of experience in a tertiary center
author Bentlin, Maria Regina [UNESP]
author_facet Bentlin, Maria Regina [UNESP]
Ferreira, Gabriel Luís [UNESP]
de Souza Rugolo, Ligia Maria Suppo [UNESP]
Silva, Geraldo Henrique Soares [UNESP]
Mondelli, Alessandro Lia [UNESP]
Rugolo Júnior, Antonio [UNESP]
author_role author
author2 Ferreira, Gabriel Luís [UNESP]
de Souza Rugolo, Ligia Maria Suppo [UNESP]
Silva, Geraldo Henrique Soares [UNESP]
Mondelli, Alessandro Lia [UNESP]
Rugolo Júnior, Antonio [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Bentlin, Maria Regina [UNESP]
Ferreira, Gabriel Luís [UNESP]
de Souza Rugolo, Ligia Maria Suppo [UNESP]
Silva, Geraldo Henrique Soares [UNESP]
Mondelli, Alessandro Lia [UNESP]
Rugolo Júnior, Antonio [UNESP]
dc.subject.por.fl_str_mv Central nervous system
Meningitis
Newborn
Sepsis
topic Central nervous system
Meningitis
Newborn
Sepsis
description The aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible were excluded. The variables investigated were birth weight, gestational and postnatal age, procedures, hematological and CSF parameters, and complications. Parametric and non-parametric tests were used (statistical value p<0.05). The incidence of meningitis was 0.6% and mortality was 27%. Of the 22 cases, 59% involved Gram-negative bacteria; 36% Gram-positive and 5% fungi. The groups did not differ in relation to birth weight, gestational and postnatal age, procedures or hematological and CSF parameters. Sepsis, convulsions and deaths were frequent in both groups, without statistical difference. Gram-negative cases showed abscesses and higher frequency of ventriculitis and hydrocephaly. Meningitis was infrequent, but presented high mortality and frequent complications.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2022-04-28T22:02:10Z
2022-04-28T22:02:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X2010000600010
Arquivos de Neuro-Psiquiatria, v. 68, n. 6, p. 882-887, 2010.
1678-4227
0004-282X
http://hdl.handle.net/11449/226213
10.1590/S0004-282X2010000600010
2-s2.0-79251590591
url http://dx.doi.org/10.1590/S0004-282X2010000600010
http://hdl.handle.net/11449/226213
identifier_str_mv Arquivos de Neuro-Psiquiatria, v. 68, n. 6, p. 882-887, 2010.
1678-4227
0004-282X
10.1590/S0004-282X2010000600010
2-s2.0-79251590591
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 882-887
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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