Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.transproceed.2021.09.016 http://hdl.handle.net/11449/222861 |
Resumo: | Background: A low supply of donated organs led to the expansion of criteria for kidney transplantation (KT), and the impact on late glomerular function rates (eGFR) is still uncertain. This study aimed to correlate the histologic findings at time-zero biopsy (TzB) with the final eGFR, to identify criteria that could help achieve a more thorough preimplantation evaluation of the organ. Methods: Records from 395 adult deceased KTs were reviewed. TzBs were analyzed considering histologic criteria by compartment (vascular, interstitial, tubular, and inflammatory) and correlated with the eGFR after 1 year. Results: Among donors, 56.9% were men (mean age 39 years), with the main causes of death being brain trauma (44.2%) and stroke (46.0%). Histologic analysis of TzB revealed 6.0% of glomerulosclerosis; 18.8% presenting vascular alterations; interstitial fibrosis in 54.6%; tubular changes in 76.9%, and nonspecific inflammatory infiltrate in 2.3%. Linear regression analysis showed that the main histologic findings that had impact in the eGFR were interstitial fibrosis (P = .000), followed by tubular alterations (P = .036) and glomerulosclerosis (P = .008). Conclusions: Histologic variables like interstitial fibrosis and tubular alterations show the most significant negative correlation with final eGFR. The effect of glomerulosclerosis may not be as important as formerly suggested in the literature. |
id |
UNSP_74ee0f3a1e2f2e98903b358f16be498f |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/222861 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Impact of Time-Zero Biopsy on the Outcome of Transplanted KidneysBackground: A low supply of donated organs led to the expansion of criteria for kidney transplantation (KT), and the impact on late glomerular function rates (eGFR) is still uncertain. This study aimed to correlate the histologic findings at time-zero biopsy (TzB) with the final eGFR, to identify criteria that could help achieve a more thorough preimplantation evaluation of the organ. Methods: Records from 395 adult deceased KTs were reviewed. TzBs were analyzed considering histologic criteria by compartment (vascular, interstitial, tubular, and inflammatory) and correlated with the eGFR after 1 year. Results: Among donors, 56.9% were men (mean age 39 years), with the main causes of death being brain trauma (44.2%) and stroke (46.0%). Histologic analysis of TzB revealed 6.0% of glomerulosclerosis; 18.8% presenting vascular alterations; interstitial fibrosis in 54.6%; tubular changes in 76.9%, and nonspecific inflammatory infiltrate in 2.3%. Linear regression analysis showed that the main histologic findings that had impact in the eGFR were interstitial fibrosis (P = .000), followed by tubular alterations (P = .036) and glomerulosclerosis (P = .008). Conclusions: Histologic variables like interstitial fibrosis and tubular alterations show the most significant negative correlation with final eGFR. The effect of glomerulosclerosis may not be as important as formerly suggested in the literature.Urology Department University of São Paulo StateNephrology Department University of São Paulo StatePathology Department University of São Paulo StateUrology Department UnicampUniversidade Estadual Paulista (UNESP)Universidade Estadual de Campinas (UNICAMP)Gomes Filho, Fernando Ferreirade Andrade, Luis Gustavo ModelliAmaro, João LuizBarreti, PasqualYamamoto, Hamilto AkihissaGuerra, RodrigoOrdones, Flavio VasconcelosPajolli, Pedro Rochettidos Santos, Daniela CristinaReis, Leonardo OliveiraKawano, Paulo Roberto2022-04-28T19:47:11Z2022-04-28T19:47:11Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.transproceed.2021.09.016Transplantation Proceedings.1873-26230041-1345http://hdl.handle.net/11449/22286110.1016/j.transproceed.2021.09.0162-s2.0-85119070000Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTransplantation Proceedingsinfo:eu-repo/semantics/openAccess2022-04-28T19:47:11Zoai:repositorio.unesp.br:11449/222861Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T21:08:33.433952Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
title |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
spellingShingle |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys Gomes Filho, Fernando Ferreira |
title_short |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
title_full |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
title_fullStr |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
title_full_unstemmed |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
title_sort |
Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys |
author |
Gomes Filho, Fernando Ferreira |
author_facet |
Gomes Filho, Fernando Ferreira de Andrade, Luis Gustavo Modelli Amaro, João Luiz Barreti, Pasqual Yamamoto, Hamilto Akihissa Guerra, Rodrigo Ordones, Flavio Vasconcelos Pajolli, Pedro Rochetti dos Santos, Daniela Cristina Reis, Leonardo Oliveira Kawano, Paulo Roberto |
author_role |
author |
author2 |
de Andrade, Luis Gustavo Modelli Amaro, João Luiz Barreti, Pasqual Yamamoto, Hamilto Akihissa Guerra, Rodrigo Ordones, Flavio Vasconcelos Pajolli, Pedro Rochetti dos Santos, Daniela Cristina Reis, Leonardo Oliveira Kawano, Paulo Roberto |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Gomes Filho, Fernando Ferreira de Andrade, Luis Gustavo Modelli Amaro, João Luiz Barreti, Pasqual Yamamoto, Hamilto Akihissa Guerra, Rodrigo Ordones, Flavio Vasconcelos Pajolli, Pedro Rochetti dos Santos, Daniela Cristina Reis, Leonardo Oliveira Kawano, Paulo Roberto |
description |
Background: A low supply of donated organs led to the expansion of criteria for kidney transplantation (KT), and the impact on late glomerular function rates (eGFR) is still uncertain. This study aimed to correlate the histologic findings at time-zero biopsy (TzB) with the final eGFR, to identify criteria that could help achieve a more thorough preimplantation evaluation of the organ. Methods: Records from 395 adult deceased KTs were reviewed. TzBs were analyzed considering histologic criteria by compartment (vascular, interstitial, tubular, and inflammatory) and correlated with the eGFR after 1 year. Results: Among donors, 56.9% were men (mean age 39 years), with the main causes of death being brain trauma (44.2%) and stroke (46.0%). Histologic analysis of TzB revealed 6.0% of glomerulosclerosis; 18.8% presenting vascular alterations; interstitial fibrosis in 54.6%; tubular changes in 76.9%, and nonspecific inflammatory infiltrate in 2.3%. Linear regression analysis showed that the main histologic findings that had impact in the eGFR were interstitial fibrosis (P = .000), followed by tubular alterations (P = .036) and glomerulosclerosis (P = .008). Conclusions: Histologic variables like interstitial fibrosis and tubular alterations show the most significant negative correlation with final eGFR. The effect of glomerulosclerosis may not be as important as formerly suggested in the literature. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:47:11Z 2022-04-28T19:47:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.transproceed.2021.09.016 Transplantation Proceedings. 1873-2623 0041-1345 http://hdl.handle.net/11449/222861 10.1016/j.transproceed.2021.09.016 2-s2.0-85119070000 |
url |
http://dx.doi.org/10.1016/j.transproceed.2021.09.016 http://hdl.handle.net/11449/222861 |
identifier_str_mv |
Transplantation Proceedings. 1873-2623 0041-1345 10.1016/j.transproceed.2021.09.016 2-s2.0-85119070000 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Transplantation Proceedings |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045720196907008 |