eIF5A: Uma proteína essencial para a viabilidade celular cuja função permanece obscura

• Autor(a) principal: Frigieri, M. C. [UNESP]
• Data de Publicação: 2006
• Outros Autores: Cano, V. S P [UNESP], Apponi, L. H. [UNESP], Dias, C. A O [UNESP], Gregio, A. P B [UNESP], João-Luiz, M. V S [UNESP], Silveira, W. S. [UNESP], Zanelli, Cleslei Fernando [UNESP], Valentini, Sandro Roberto [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/381; http://hdl.handle.net/11449/69339
• topic: Cell proliferation; eIF5A; Hypusine; Protein synthesis; Translation; initiation factor; messenger RNA; translation initiation factor 5a; unclassified drug; cell cycle progression; cell proliferation; cell viability; nucleocytoplasmic transport; protein function; review; RNA metabolism; RNA translation

The putative translation initiation factor 5A (eIF5A) is a highly abundant and conserved protein in all eukaryotes and archaebacteria. This factor is essential for cell viability and is the only cellular protein known to contain the unusual amino acid residue hypusine. In Saccharomyces cerevisiae eIF5A is expressed in aerobic conditions by the gene TIF51A. Although eIF5A has been known for almost 30 years, the biological role of this protein is still obscure. This article reviews the research on the function of eIF5A, discussing the evidence for its involvement in various steps of mRNA metabolism, including translation initiation, nucleocytoplasmic transport and mRNA decay. Moreover, it indicates other studies that have associated eIF5A with cell proliferation and cell cycle progression. Finally, this review presents recent results obtained in our laboratory that reemphasize the role of eIF5A in the translation scenario. Further experiments will be necessary to define the role played by eIF5A in the translational machinery.