Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines

Detalhes bibliográficos
Autor(a) principal: Barbosa, Maurício Fregonesi [UNESP]
Data de Publicação: 2021
Outros Autores: Fusco, Daniéliso Renato [UNESP], Gaiolla, Rafael Dezen [UNESP], Werys, Konrad, Tanni, Suzana Erico [UNESP], Fernandes, Rômulo Araújo [UNESP], Ribeiro, Sergio Marrone [UNESP], Szarf, Gilberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/s12872-021-01996-6
http://hdl.handle.net/11449/206193
Resumo: Background: The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset of survivors who would eventually benefit from early intervention. Cardiac magnetic resonance feature-tracking (CMR-FT) analysis offers a practical and rapid method to calculate systolic and diastolic strains from routinely acquired cine images. While early changes in systolic function have been described, less data are available about late effects of chemotherapy in diastolic parameters by CMR-FT. The main goal of this study was to determine whether left ventricular (LV) early diastolic strain rates (GDSR-E) by CMR-FT are impaired in long-term adult survivors of non-Hodgkin lymphoma (NHL). Our secondary objective was to analyze associations between GDSR-E with cumulative anthracycline dose, systolic function parameters and myocardial tissue characteristics. Methods: This is a single center cross-sectional observational study of asymptomatic patients in remission of NHL who previously received anthracycline therapy. All participants underwent their CMR examination on a 3.0-T scanner, including cines, T2 mapping, T1 mapping and late gadolinium enhancement imaging. Derived myocardial extracellular volume fraction was obtained from pre- and post-contrast T1 maps. CMR-FT analysis was performed using Trufi Strain software. The data obtained were compared between anthracycline group and volunteers without cardiovascular disease or neoplasia. Results: A total of 18 adult survivors of NHL, 14 (77.8%) males, at mean age of 57.6 (± 14.7) years-old, were studied 88.2 (± 52.1) months after exposure to anthracycline therapy (median 400 mg/m2). Compared with controls, anthracycline group showed impaired LV global early diastolic circumferential strain rate (GCSR-E) [53.5%/s ± 19.3 vs 72.2%/s ± 26.7, p = 0.022], early diastolic longitudinal strain rate (GLSR-E) [40.4%/s ± 13.0 vs 55.9%/s ± 17.8, p = 0.006] and early diastolic radial strain rate (GRSR-E) [− 114.4%/s ± 37.1 vs − 170.5%/s ± 48.0, p < 0.001]. Impaired LV GCSR-E, GLSR-E and GRSR-E correlated with increased anthracycline dose and decreased systolic function. There were no correlations between GDSR-E and myocardial tissue characteristics. Conclusions: Left ventricular early diastolic strain rates by CMR-FT are impaired late after anthracycline chemotherapy in adult survivors of non-Hodgkin lymphoma.
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spelling Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclinesCancerChemotherapyDiastolic dysfunctionFeature-trackingStrainBackground: The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset of survivors who would eventually benefit from early intervention. Cardiac magnetic resonance feature-tracking (CMR-FT) analysis offers a practical and rapid method to calculate systolic and diastolic strains from routinely acquired cine images. While early changes in systolic function have been described, less data are available about late effects of chemotherapy in diastolic parameters by CMR-FT. The main goal of this study was to determine whether left ventricular (LV) early diastolic strain rates (GDSR-E) by CMR-FT are impaired in long-term adult survivors of non-Hodgkin lymphoma (NHL). Our secondary objective was to analyze associations between GDSR-E with cumulative anthracycline dose, systolic function parameters and myocardial tissue characteristics. Methods: This is a single center cross-sectional observational study of asymptomatic patients in remission of NHL who previously received anthracycline therapy. All participants underwent their CMR examination on a 3.0-T scanner, including cines, T2 mapping, T1 mapping and late gadolinium enhancement imaging. Derived myocardial extracellular volume fraction was obtained from pre- and post-contrast T1 maps. CMR-FT analysis was performed using Trufi Strain software. The data obtained were compared between anthracycline group and volunteers without cardiovascular disease or neoplasia. Results: A total of 18 adult survivors of NHL, 14 (77.8%) males, at mean age of 57.6 (± 14.7) years-old, were studied 88.2 (± 52.1) months after exposure to anthracycline therapy (median 400 mg/m2). Compared with controls, anthracycline group showed impaired LV global early diastolic circumferential strain rate (GCSR-E) [53.5%/s ± 19.3 vs 72.2%/s ± 26.7, p = 0.022], early diastolic longitudinal strain rate (GLSR-E) [40.4%/s ± 13.0 vs 55.9%/s ± 17.8, p = 0.006] and early diastolic radial strain rate (GRSR-E) [− 114.4%/s ± 37.1 vs − 170.5%/s ± 48.0, p < 0.001]. Impaired LV GCSR-E, GLSR-E and GRSR-E correlated with increased anthracycline dose and decreased systolic function. There were no correlations between GDSR-E and myocardial tissue characteristics. Conclusions: Left ventricular early diastolic strain rates by CMR-FT are impaired late after anthracycline chemotherapy in adult survivors of non-Hodgkin lymphoma.Department of Diagnostic Imaging Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros 800, Vila ClementinoDepartment of Tropical Diseases and Diagnostic Imaging Universidade Estadual Paulista (UNESP)Cardiology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)Hematology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of OxfordPneumology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)Department of Physical Education Universidade Estadual Paulista (UNESP)Hospital Israelita Albert EinsteinDepartment of Tropical Diseases and Diagnostic Imaging Universidade Estadual Paulista (UNESP)Cardiology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)Hematology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)Pneumology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)Department of Physical Education Universidade Estadual Paulista (UNESP)Universidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)University of OxfordHospital Israelita Albert EinsteinBarbosa, Maurício Fregonesi [UNESP]Fusco, Daniéliso Renato [UNESP]Gaiolla, Rafael Dezen [UNESP]Werys, KonradTanni, Suzana Erico [UNESP]Fernandes, Rômulo Araújo [UNESP]Ribeiro, Sergio Marrone [UNESP]Szarf, Gilberto2021-06-25T10:28:04Z2021-06-25T10:28:04Z2021-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12872-021-01996-6BMC Cardiovascular Disorders, v. 21, n. 1, 2021.1471-2261http://hdl.handle.net/11449/20619310.1186/s12872-021-01996-62-s2.0-85104159254Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Cardiovascular Disordersinfo:eu-repo/semantics/openAccess2021-10-22T22:17:21Zoai:repositorio.unesp.br:11449/206193Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:58:21.565835Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
title Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
spellingShingle Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
Barbosa, Maurício Fregonesi [UNESP]
Cancer
Chemotherapy
Diastolic dysfunction
Feature-tracking
Strain
title_short Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
title_full Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
title_fullStr Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
title_full_unstemmed Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
title_sort Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines
author Barbosa, Maurício Fregonesi [UNESP]
author_facet Barbosa, Maurício Fregonesi [UNESP]
Fusco, Daniéliso Renato [UNESP]
Gaiolla, Rafael Dezen [UNESP]
Werys, Konrad
Tanni, Suzana Erico [UNESP]
Fernandes, Rômulo Araújo [UNESP]
Ribeiro, Sergio Marrone [UNESP]
Szarf, Gilberto
author_role author
author2 Fusco, Daniéliso Renato [UNESP]
Gaiolla, Rafael Dezen [UNESP]
Werys, Konrad
Tanni, Suzana Erico [UNESP]
Fernandes, Rômulo Araújo [UNESP]
Ribeiro, Sergio Marrone [UNESP]
Szarf, Gilberto
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (Unesp)
University of Oxford
Hospital Israelita Albert Einstein
dc.contributor.author.fl_str_mv Barbosa, Maurício Fregonesi [UNESP]
Fusco, Daniéliso Renato [UNESP]
Gaiolla, Rafael Dezen [UNESP]
Werys, Konrad
Tanni, Suzana Erico [UNESP]
Fernandes, Rômulo Araújo [UNESP]
Ribeiro, Sergio Marrone [UNESP]
Szarf, Gilberto
dc.subject.por.fl_str_mv Cancer
Chemotherapy
Diastolic dysfunction
Feature-tracking
Strain
topic Cancer
Chemotherapy
Diastolic dysfunction
Feature-tracking
Strain
description Background: The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset of survivors who would eventually benefit from early intervention. Cardiac magnetic resonance feature-tracking (CMR-FT) analysis offers a practical and rapid method to calculate systolic and diastolic strains from routinely acquired cine images. While early changes in systolic function have been described, less data are available about late effects of chemotherapy in diastolic parameters by CMR-FT. The main goal of this study was to determine whether left ventricular (LV) early diastolic strain rates (GDSR-E) by CMR-FT are impaired in long-term adult survivors of non-Hodgkin lymphoma (NHL). Our secondary objective was to analyze associations between GDSR-E with cumulative anthracycline dose, systolic function parameters and myocardial tissue characteristics. Methods: This is a single center cross-sectional observational study of asymptomatic patients in remission of NHL who previously received anthracycline therapy. All participants underwent their CMR examination on a 3.0-T scanner, including cines, T2 mapping, T1 mapping and late gadolinium enhancement imaging. Derived myocardial extracellular volume fraction was obtained from pre- and post-contrast T1 maps. CMR-FT analysis was performed using Trufi Strain software. The data obtained were compared between anthracycline group and volunteers without cardiovascular disease or neoplasia. Results: A total of 18 adult survivors of NHL, 14 (77.8%) males, at mean age of 57.6 (± 14.7) years-old, were studied 88.2 (± 52.1) months after exposure to anthracycline therapy (median 400 mg/m2). Compared with controls, anthracycline group showed impaired LV global early diastolic circumferential strain rate (GCSR-E) [53.5%/s ± 19.3 vs 72.2%/s ± 26.7, p = 0.022], early diastolic longitudinal strain rate (GLSR-E) [40.4%/s ± 13.0 vs 55.9%/s ± 17.8, p = 0.006] and early diastolic radial strain rate (GRSR-E) [− 114.4%/s ± 37.1 vs − 170.5%/s ± 48.0, p < 0.001]. Impaired LV GCSR-E, GLSR-E and GRSR-E correlated with increased anthracycline dose and decreased systolic function. There were no correlations between GDSR-E and myocardial tissue characteristics. Conclusions: Left ventricular early diastolic strain rates by CMR-FT are impaired late after anthracycline chemotherapy in adult survivors of non-Hodgkin lymphoma.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:28:04Z
2021-06-25T10:28:04Z
2021-12-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s12872-021-01996-6
BMC Cardiovascular Disorders, v. 21, n. 1, 2021.
1471-2261
http://hdl.handle.net/11449/206193
10.1186/s12872-021-01996-6
2-s2.0-85104159254
url http://dx.doi.org/10.1186/s12872-021-01996-6
http://hdl.handle.net/11449/206193
identifier_str_mv BMC Cardiovascular Disorders, v. 21, n. 1, 2021.
1471-2261
10.1186/s12872-021-01996-6
2-s2.0-85104159254
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Cardiovascular Disorders
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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