Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.humov.2018.02.012 http://hdl.handle.net/11449/177100 |
Resumo: | Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing. |
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spelling |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot studyHandwritingNon-invasive brain stimulationParkinson's diseaseTranscranial direct current stimulationUpper limb freezingTranscranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing.Neuromotor Rehabilitation Research Group, Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, Leuven, BelgiumMovement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven, Tervuursevest 101, Leuven, BelgiumRehabilitation Research Institute, Biomedical Research Institute, Campus Diepenbeek, Hasselt University, Agoralaan Gebouw C, Diepenbeek, BelgiumPosture and Locomotion Studies Laboratory, Physical Education Department-UNESP, Sao Paulo State University, Avenue 24-A-1515, Rio Claro, BrazilUniversidade Estadual Paulista (Unesp)Broeder, SanneHeremans, ElkePinto Pereira, MarceloNackaerts, EvelienMeesen, RafVerheyden, GeertNieuwboer, Alice2018-12-11T17:24:00Z2018-12-11T17:24:00Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.humov.2018.02.012Human Movement Science.1872-76460167-9457http://hdl.handle.net/11449/17710010.1016/j.humov.2018.02.0122-s2.0-850426657622-s2.0-85042665762.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHuman Movement Science0,756info:eu-repo/semantics/openAccess2023-10-08T06:05:18Zoai:repositorio.unesp.br:11449/177100Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:19:40.608411Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
title |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
spellingShingle |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study Broeder, Sanne Handwriting Non-invasive brain stimulation Parkinson's disease Transcranial direct current stimulation Upper limb freezing |
title_short |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
title_full |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
title_fullStr |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
title_full_unstemmed |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
title_sort |
Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study |
author |
Broeder, Sanne |
author_facet |
Broeder, Sanne Heremans, Elke Pinto Pereira, Marcelo Nackaerts, Evelien Meesen, Raf Verheyden, Geert Nieuwboer, Alice |
author_role |
author |
author2 |
Heremans, Elke Pinto Pereira, Marcelo Nackaerts, Evelien Meesen, Raf Verheyden, Geert Nieuwboer, Alice |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Broeder, Sanne Heremans, Elke Pinto Pereira, Marcelo Nackaerts, Evelien Meesen, Raf Verheyden, Geert Nieuwboer, Alice |
dc.subject.por.fl_str_mv |
Handwriting Non-invasive brain stimulation Parkinson's disease Transcranial direct current stimulation Upper limb freezing |
topic |
Handwriting Non-invasive brain stimulation Parkinson's disease Transcranial direct current stimulation Upper limb freezing |
description |
Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:24:00Z 2018-12-11T17:24:00Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.humov.2018.02.012 Human Movement Science. 1872-7646 0167-9457 http://hdl.handle.net/11449/177100 10.1016/j.humov.2018.02.012 2-s2.0-85042665762 2-s2.0-85042665762.pdf |
url |
http://dx.doi.org/10.1016/j.humov.2018.02.012 http://hdl.handle.net/11449/177100 |
identifier_str_mv |
Human Movement Science. 1872-7646 0167-9457 10.1016/j.humov.2018.02.012 2-s2.0-85042665762 2-s2.0-85042665762.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Human Movement Science 0,756 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128347920662528 |