Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sciencedirect.com/science/article/pii/S0024320515000983 http://hdl.handle.net/11449/128290 |
Resumo: | Aims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure <60 mm Hg) Hg) was precipitated by sildenafil due to systemic vasodilation in the Emb + Sil(21) group. Embolization lowered the PaO2/FiO(2) ratio and increased venous admixture, but sildenafil did not alter the oxygenation impairment induced by APE.Significance: Sildenafil induces a more consistent pulmonary anti-hypertensive effect and causes less interference with the systemic circulation with the concomitant use of pure oxygen than that with room air in the APE setting. (C) 2015 Elsevier Inc. All rights reserved. |
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Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolismAcute pulmonary embolismSildenafilPulmonary hypertensionAims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure <60 mm Hg) Hg) was precipitated by sildenafil due to systemic vasodilation in the Emb + Sil(21) group. Embolization lowered the PaO2/FiO(2) ratio and increased venous admixture, but sildenafil did not alter the oxygenation impairment induced by APE.Significance: Sildenafil induces a more consistent pulmonary anti-hypertensive effect and causes less interference with the systemic circulation with the concomitant use of pure oxygen than that with room air in the APE setting. (C) 2015 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, Fac Med Vet &Zootecnia, Dept Cinagia &Anestesiol Vet, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med, Dept Anestesiol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Farmacol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet &Zootecnia, Dept Cinagia &Anestesiol Vet, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med, Dept Anestesiol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Farmacol, BR-18618970 Botucatu, SP, BrazilFAPESP: 2012/12.291-7Elsevier B.V.Universidade Estadual Paulista (Unesp)Becerra Velasquez, Diana Rocio [UNESP]Teixeira-Neto, Francisco Jose [UNESP]Lagos-Carvajal, Angie Paola [UNESP]Steim-Diniz, Miriely [UNESP]Rodriguez, Nathalia Celeita [UNESP]Dias-Junior, Carlos Alan [UNESP]2015-10-21T13:08:45Z2015-10-21T13:08:45Z2015-04-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article26-31http://www.sciencedirect.com/science/article/pii/S0024320515000983Life Sciences, v. 127, p. 26-31, 2015.0024-3205http://hdl.handle.net/11449/12829010.1016/j.lfs.2015.02.005WOS:000353859500004Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciences3.2341,071info:eu-repo/semantics/openAccess2024-08-14T13:20:38Zoai:repositorio.unesp.br:11449/128290Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T13:20:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
title |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
spellingShingle |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism Becerra Velasquez, Diana Rocio [UNESP] Acute pulmonary embolism Sildenafil Pulmonary hypertension |
title_short |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
title_full |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
title_fullStr |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
title_full_unstemmed |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
title_sort |
Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism |
author |
Becerra Velasquez, Diana Rocio [UNESP] |
author_facet |
Becerra Velasquez, Diana Rocio [UNESP] Teixeira-Neto, Francisco Jose [UNESP] Lagos-Carvajal, Angie Paola [UNESP] Steim-Diniz, Miriely [UNESP] Rodriguez, Nathalia Celeita [UNESP] Dias-Junior, Carlos Alan [UNESP] |
author_role |
author |
author2 |
Teixeira-Neto, Francisco Jose [UNESP] Lagos-Carvajal, Angie Paola [UNESP] Steim-Diniz, Miriely [UNESP] Rodriguez, Nathalia Celeita [UNESP] Dias-Junior, Carlos Alan [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Becerra Velasquez, Diana Rocio [UNESP] Teixeira-Neto, Francisco Jose [UNESP] Lagos-Carvajal, Angie Paola [UNESP] Steim-Diniz, Miriely [UNESP] Rodriguez, Nathalia Celeita [UNESP] Dias-Junior, Carlos Alan [UNESP] |
dc.subject.por.fl_str_mv |
Acute pulmonary embolism Sildenafil Pulmonary hypertension |
topic |
Acute pulmonary embolism Sildenafil Pulmonary hypertension |
description |
Aims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure <60 mm Hg) Hg) was precipitated by sildenafil due to systemic vasodilation in the Emb + Sil(21) group. Embolization lowered the PaO2/FiO(2) ratio and increased venous admixture, but sildenafil did not alter the oxygenation impairment induced by APE.Significance: Sildenafil induces a more consistent pulmonary anti-hypertensive effect and causes less interference with the systemic circulation with the concomitant use of pure oxygen than that with room air in the APE setting. (C) 2015 Elsevier Inc. All rights reserved. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:08:45Z 2015-10-21T13:08:45Z 2015-04-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S0024320515000983 Life Sciences, v. 127, p. 26-31, 2015. 0024-3205 http://hdl.handle.net/11449/128290 10.1016/j.lfs.2015.02.005 WOS:000353859500004 |
url |
http://www.sciencedirect.com/science/article/pii/S0024320515000983 http://hdl.handle.net/11449/128290 |
identifier_str_mv |
Life Sciences, v. 127, p. 26-31, 2015. 0024-3205 10.1016/j.lfs.2015.02.005 WOS:000353859500004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences 3.234 1,071 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
26-31 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128172514869248 |