Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism

Detalhes bibliográficos
Autor(a) principal: Becerra Velasquez, Diana Rocio [UNESP]
Data de Publicação: 2015
Outros Autores: Teixeira-Neto, Francisco Jose [UNESP], Lagos-Carvajal, Angie Paola [UNESP], Steim-Diniz, Miriely [UNESP], Rodriguez, Nathalia Celeita [UNESP], Dias-Junior, Carlos Alan [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.sciencedirect.com/science/article/pii/S0024320515000983
http://hdl.handle.net/11449/128290
Resumo: Aims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure <60 mm Hg) Hg) was precipitated by sildenafil due to systemic vasodilation in the Emb + Sil(21) group. Embolization lowered the PaO2/FiO(2) ratio and increased venous admixture, but sildenafil did not alter the oxygenation impairment induced by APE.Significance: Sildenafil induces a more consistent pulmonary anti-hypertensive effect and causes less interference with the systemic circulation with the concomitant use of pure oxygen than that with room air in the APE setting. (C) 2015 Elsevier Inc. All rights reserved.
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spelling Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolismAcute pulmonary embolismSildenafilPulmonary hypertensionAims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure <60 mm Hg) Hg) was precipitated by sildenafil due to systemic vasodilation in the Emb + Sil(21) group. Embolization lowered the PaO2/FiO(2) ratio and increased venous admixture, but sildenafil did not alter the oxygenation impairment induced by APE.Significance: Sildenafil induces a more consistent pulmonary anti-hypertensive effect and causes less interference with the systemic circulation with the concomitant use of pure oxygen than that with room air in the APE setting. (C) 2015 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, Fac Med Vet &Zootecnia, Dept Cinagia &Anestesiol Vet, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med, Dept Anestesiol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Farmacol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet &Zootecnia, Dept Cinagia &Anestesiol Vet, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med, Dept Anestesiol, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Farmacol, BR-18618970 Botucatu, SP, BrazilFAPESP: 2012/12.291-7Elsevier B.V.Universidade Estadual Paulista (Unesp)Becerra Velasquez, Diana Rocio [UNESP]Teixeira-Neto, Francisco Jose [UNESP]Lagos-Carvajal, Angie Paola [UNESP]Steim-Diniz, Miriely [UNESP]Rodriguez, Nathalia Celeita [UNESP]Dias-Junior, Carlos Alan [UNESP]2015-10-21T13:08:45Z2015-10-21T13:08:45Z2015-04-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article26-31http://www.sciencedirect.com/science/article/pii/S0024320515000983Life Sciences, v. 127, p. 26-31, 2015.0024-3205http://hdl.handle.net/11449/12829010.1016/j.lfs.2015.02.005WOS:000353859500004Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciences3.2341,071info:eu-repo/semantics/openAccess2024-08-14T13:20:38Zoai:repositorio.unesp.br:11449/128290Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T13:20:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
title Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
spellingShingle Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
Becerra Velasquez, Diana Rocio [UNESP]
Acute pulmonary embolism
Sildenafil
Pulmonary hypertension
title_short Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
title_full Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
title_fullStr Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
title_full_unstemmed Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
title_sort Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
author Becerra Velasquez, Diana Rocio [UNESP]
author_facet Becerra Velasquez, Diana Rocio [UNESP]
Teixeira-Neto, Francisco Jose [UNESP]
Lagos-Carvajal, Angie Paola [UNESP]
Steim-Diniz, Miriely [UNESP]
Rodriguez, Nathalia Celeita [UNESP]
Dias-Junior, Carlos Alan [UNESP]
author_role author
author2 Teixeira-Neto, Francisco Jose [UNESP]
Lagos-Carvajal, Angie Paola [UNESP]
Steim-Diniz, Miriely [UNESP]
Rodriguez, Nathalia Celeita [UNESP]
Dias-Junior, Carlos Alan [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Becerra Velasquez, Diana Rocio [UNESP]
Teixeira-Neto, Francisco Jose [UNESP]
Lagos-Carvajal, Angie Paola [UNESP]
Steim-Diniz, Miriely [UNESP]
Rodriguez, Nathalia Celeita [UNESP]
Dias-Junior, Carlos Alan [UNESP]
dc.subject.por.fl_str_mv Acute pulmonary embolism
Sildenafil
Pulmonary hypertension
topic Acute pulmonary embolism
Sildenafil
Pulmonary hypertension
description Aims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure <60 mm Hg) Hg) was precipitated by sildenafil due to systemic vasodilation in the Emb + Sil(21) group. Embolization lowered the PaO2/FiO(2) ratio and increased venous admixture, but sildenafil did not alter the oxygenation impairment induced by APE.Significance: Sildenafil induces a more consistent pulmonary anti-hypertensive effect and causes less interference with the systemic circulation with the concomitant use of pure oxygen than that with room air in the APE setting. (C) 2015 Elsevier Inc. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-21T13:08:45Z
2015-10-21T13:08:45Z
2015-04-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.sciencedirect.com/science/article/pii/S0024320515000983
Life Sciences, v. 127, p. 26-31, 2015.
0024-3205
http://hdl.handle.net/11449/128290
10.1016/j.lfs.2015.02.005
WOS:000353859500004
url http://www.sciencedirect.com/science/article/pii/S0024320515000983
http://hdl.handle.net/11449/128290
identifier_str_mv Life Sciences, v. 127, p. 26-31, 2015.
0024-3205
10.1016/j.lfs.2015.02.005
WOS:000353859500004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Life Sciences
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dc.format.none.fl_str_mv 26-31
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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instname_str Universidade Estadual Paulista (UNESP)
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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