Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/etc.4938 http://hdl.handle.net/11449/209900 |
Resumo: | Thymol, a monoterpene phenol, is used as a natural biocide. To circumvent its chemical instability, we propose use of thymol-loaded biogenic silica nanoparticles (BSiO2#THY NPs); however, the toxicity of this system for aquatic organisms is unknown. Thus, the present study aimed to evaluate the toxicogenetic effects induced by thymol, BSiO2 NP, and BSiO2#THY on Artemia salina and zebrafish (Danio rerio) early life stages. We also investigated the impact of BSiO2 aggregation in different exposure media (saline and freshwater). Based on the median lethal concentration at 48 h (LC50(48h)), BSiO2#THY (LC50(48h) = 1.06 mg/L) presented similar toxic potential as thymol (LC50(48h) = 1.03 mg/L) for A. salina, showing that BSiO2 had no influence on BSiO2#THY toxicity. Because BSiO2 aggregated and sedimented faster in A. salina aqueous medium than in the other medium, this NP had lower interaction with this microcrustacean. Thus, BSiO2#THY toxicity for A. salina is probably due to the intrinsic toxicity of thymol. For zebrafish early life stages, BSiO2#THY (LC50(96h) = 13.13 mg/L) was more toxic than free thymol (LC50(96h) = 25.60 mg/L); however, BSiO2 NP has no toxicity for zebrafish early life stages. The lower aggregation of BSiO2 in the freshwater medium compared to the saline medium may have enhanced thymol's availability for this aquatic organism. Also, BSiO2#THY significantly induced sublethal effects as thymol, and both were genotoxic for zebrafish. In conclusion, although BSiO2#THY still needs improvements to ensure its safety for freshwater ecosystems, BSiO2 NP seems to be a safe nanocarrier for agriculture. Environ Toxicol Chem 2021;00:1-9. (c) 2020 SETAC |
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Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on EcotoxicityBiocide delivery systemsNanoparticlesAggregationZebrafishArtemia salinaComet assayThymol, a monoterpene phenol, is used as a natural biocide. To circumvent its chemical instability, we propose use of thymol-loaded biogenic silica nanoparticles (BSiO2#THY NPs); however, the toxicity of this system for aquatic organisms is unknown. Thus, the present study aimed to evaluate the toxicogenetic effects induced by thymol, BSiO2 NP, and BSiO2#THY on Artemia salina and zebrafish (Danio rerio) early life stages. We also investigated the impact of BSiO2 aggregation in different exposure media (saline and freshwater). Based on the median lethal concentration at 48 h (LC50(48h)), BSiO2#THY (LC50(48h) = 1.06 mg/L) presented similar toxic potential as thymol (LC50(48h) = 1.03 mg/L) for A. salina, showing that BSiO2 had no influence on BSiO2#THY toxicity. Because BSiO2 aggregated and sedimented faster in A. salina aqueous medium than in the other medium, this NP had lower interaction with this microcrustacean. Thus, BSiO2#THY toxicity for A. salina is probably due to the intrinsic toxicity of thymol. For zebrafish early life stages, BSiO2#THY (LC50(96h) = 13.13 mg/L) was more toxic than free thymol (LC50(96h) = 25.60 mg/L); however, BSiO2 NP has no toxicity for zebrafish early life stages. The lower aggregation of BSiO2 in the freshwater medium compared to the saline medium may have enhanced thymol's availability for this aquatic organism. Also, BSiO2#THY significantly induced sublethal effects as thymol, and both were genotoxic for zebrafish. In conclusion, although BSiO2#THY still needs improvements to ensure its safety for freshwater ecosystems, BSiO2 NP seems to be a safe nanocarrier for agriculture. Environ Toxicol Chem 2021;00:1-9. (c) 2020 SETACGoias Research FoundationCoordination of Superior Level Staff ImprovementNational Council for Scientific and Technological Development (INCT/DATREM)Araucaria FoundationUniv Fed Goias, Fac Pharm, Environm Toxicol Res Lab, Goiania, Go, BrazilAalto Univ, Sch Chem Engn, Dept Bioprod & Biosyst, Aalto, FinlandEmbrapa Florestas, Colombo, Parana, BrazilUniv Fed Parana, Dept Genet, Curitiba, Parana, BrazilSao Paulo State Univ, Inst Chem, Natl Inst Alternat Technol Detect Toxicol Evaluat, Araraquara, SP, BrazilUniv Fed Goias, Fac Pharm, Lab Nanosyst & Drug Delivery Syst, Goiania, Go, BrazilSao Paulo State Univ, Inst Chem, Natl Inst Alternat Technol Detect Toxicol Evaluat, Araraquara, SP, BrazilNational Council for Scientific and Technological Development (INCT/DATREM): 465571/2014-0Wiley-BlackwellUniversidade Federal de Goiás (UFG)Aalto UnivEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Univ Fed ParanaUniversidade Estadual Paulista (Unesp)Pereira, Iuri BarbosaCarvalho, Endrew Henrique de SousaRodrigues, Lais de BritoMattos, Bruno DufauMagalhaes, Washington Luiz EstevesLeme, Daniela Morais [UNESP]Krawczyk-Santos, Anna PaulaTaveira, Stephania FleuryOliveira, Gisele Augusto Rodrigues de [UNESP]2021-06-25T12:33:07Z2021-06-25T12:33:07Z2021-01-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article333-341http://dx.doi.org/10.1002/etc.4938Environmental Toxicology And Chemistry. Hoboken: Wiley, v. 40, n. 2, p. 333-341, 2021.0730-7268http://hdl.handle.net/11449/20990010.1002/etc.4938WOS:000607264100001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Toxicology And Chemistryinfo:eu-repo/semantics/openAccess2024-06-24T14:51:53Zoai:repositorio.unesp.br:11449/209900Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:59:36.764585Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
title |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
spellingShingle |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity Pereira, Iuri Barbosa Biocide delivery systems Nanoparticles Aggregation Zebrafish Artemia salina Comet assay |
title_short |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
title_full |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
title_fullStr |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
title_full_unstemmed |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
title_sort |
Thymol-Loaded Biogenic Silica Nanoparticles in an Aquatic Environment: The Impact of Particle Aggregation on Ecotoxicity |
author |
Pereira, Iuri Barbosa |
author_facet |
Pereira, Iuri Barbosa Carvalho, Endrew Henrique de Sousa Rodrigues, Lais de Brito Mattos, Bruno Dufau Magalhaes, Washington Luiz Esteves Leme, Daniela Morais [UNESP] Krawczyk-Santos, Anna Paula Taveira, Stephania Fleury Oliveira, Gisele Augusto Rodrigues de [UNESP] |
author_role |
author |
author2 |
Carvalho, Endrew Henrique de Sousa Rodrigues, Lais de Brito Mattos, Bruno Dufau Magalhaes, Washington Luiz Esteves Leme, Daniela Morais [UNESP] Krawczyk-Santos, Anna Paula Taveira, Stephania Fleury Oliveira, Gisele Augusto Rodrigues de [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Aalto Univ Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Univ Fed Parana Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pereira, Iuri Barbosa Carvalho, Endrew Henrique de Sousa Rodrigues, Lais de Brito Mattos, Bruno Dufau Magalhaes, Washington Luiz Esteves Leme, Daniela Morais [UNESP] Krawczyk-Santos, Anna Paula Taveira, Stephania Fleury Oliveira, Gisele Augusto Rodrigues de [UNESP] |
dc.subject.por.fl_str_mv |
Biocide delivery systems Nanoparticles Aggregation Zebrafish Artemia salina Comet assay |
topic |
Biocide delivery systems Nanoparticles Aggregation Zebrafish Artemia salina Comet assay |
description |
Thymol, a monoterpene phenol, is used as a natural biocide. To circumvent its chemical instability, we propose use of thymol-loaded biogenic silica nanoparticles (BSiO2#THY NPs); however, the toxicity of this system for aquatic organisms is unknown. Thus, the present study aimed to evaluate the toxicogenetic effects induced by thymol, BSiO2 NP, and BSiO2#THY on Artemia salina and zebrafish (Danio rerio) early life stages. We also investigated the impact of BSiO2 aggregation in different exposure media (saline and freshwater). Based on the median lethal concentration at 48 h (LC50(48h)), BSiO2#THY (LC50(48h) = 1.06 mg/L) presented similar toxic potential as thymol (LC50(48h) = 1.03 mg/L) for A. salina, showing that BSiO2 had no influence on BSiO2#THY toxicity. Because BSiO2 aggregated and sedimented faster in A. salina aqueous medium than in the other medium, this NP had lower interaction with this microcrustacean. Thus, BSiO2#THY toxicity for A. salina is probably due to the intrinsic toxicity of thymol. For zebrafish early life stages, BSiO2#THY (LC50(96h) = 13.13 mg/L) was more toxic than free thymol (LC50(96h) = 25.60 mg/L); however, BSiO2 NP has no toxicity for zebrafish early life stages. The lower aggregation of BSiO2 in the freshwater medium compared to the saline medium may have enhanced thymol's availability for this aquatic organism. Also, BSiO2#THY significantly induced sublethal effects as thymol, and both were genotoxic for zebrafish. In conclusion, although BSiO2#THY still needs improvements to ensure its safety for freshwater ecosystems, BSiO2 NP seems to be a safe nanocarrier for agriculture. Environ Toxicol Chem 2021;00:1-9. (c) 2020 SETAC |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T12:33:07Z 2021-06-25T12:33:07Z 2021-01-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/etc.4938 Environmental Toxicology And Chemistry. Hoboken: Wiley, v. 40, n. 2, p. 333-341, 2021. 0730-7268 http://hdl.handle.net/11449/209900 10.1002/etc.4938 WOS:000607264100001 |
url |
http://dx.doi.org/10.1002/etc.4938 http://hdl.handle.net/11449/209900 |
identifier_str_mv |
Environmental Toxicology And Chemistry. Hoboken: Wiley, v. 40, n. 2, p. 333-341, 2021. 0730-7268 10.1002/etc.4938 WOS:000607264100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Toxicology And Chemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
333-341 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129271565123584 |