Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11250-021-02795-z http://hdl.handle.net/11449/221769 |
Resumo: | The aim of this study was to identify candidate genes associated with milk fat per cent and fatty acid (FA) composition in Vrindavani cattle using the Illumina 50 K single-nucleotide polymorphism (SNP) array. After quality control, a total of 41,427 informative and high-quality SNPs were used for a genome-wide association study (GWAS) for milk fat percentage and 16 different types of fatty acids. Lactation stage, parity, test day milk yield, and proportion of exotic inheritance were included as fixed effects in the GWAS model. A total of 67 genome-wide significant (P < 1.20 × 10−06) SNPs and 176 suggestive significant (P < 2.41 × 10−05) SNPs were identified. Out of these, 15 SNPs were associated with more than one trait. The strongest associations were found on BTA14 for milk fat percentage and on BTA2 and BTA16 for polyunsaturated fatty acids. Several significant SNPs were identified close to or within the genes ELOVL6, FABP4, PMP2, PLIN1, MFGE8, GHRL2, and LDLRAD3 which are known to be associated with fat percentage and FA composition in dairy cattle breeds. This study is a step forward to better characterize the molecular mechanisms of phenotypic variation in milk fatty acids in a taurine–indicine composite cattle breed reared in tropical environments. |
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Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-ChipComposite cattleGenome-wide association studiesMilk fatty acidVrindavani cattleThe aim of this study was to identify candidate genes associated with milk fat per cent and fatty acid (FA) composition in Vrindavani cattle using the Illumina 50 K single-nucleotide polymorphism (SNP) array. After quality control, a total of 41,427 informative and high-quality SNPs were used for a genome-wide association study (GWAS) for milk fat percentage and 16 different types of fatty acids. Lactation stage, parity, test day milk yield, and proportion of exotic inheritance were included as fixed effects in the GWAS model. A total of 67 genome-wide significant (P < 1.20 × 10−06) SNPs and 176 suggestive significant (P < 2.41 × 10−05) SNPs were identified. Out of these, 15 SNPs were associated with more than one trait. The strongest associations were found on BTA14 for milk fat percentage and on BTA2 and BTA16 for polyunsaturated fatty acids. Several significant SNPs were identified close to or within the genes ELOVL6, FABP4, PMP2, PLIN1, MFGE8, GHRL2, and LDLRAD3 which are known to be associated with fat percentage and FA composition in dairy cattle breeds. This study is a step forward to better characterize the molecular mechanisms of phenotypic variation in milk fatty acids in a taurine–indicine composite cattle breed reared in tropical environments.Animal Genetics Division ICAR-Indian Veterinary Research Institute, IzatnagarDepartment of Animal Science Michigan State UniversityDepartment of Animal Science São Paulo State UniversityLivestock Production and Management Division ICAR-Indian Veterinary Research Institute, IzatnagarAnimal Biotechnology Division ICAR-Indian Veterinary Research Institute, IzatnagarDepartment of Animal Science São Paulo State UniversityICAR-Indian Veterinary Research InstituteMichigan State UniversityUniversidade Estadual Paulista (UNESP)Singh, AkanshaKumar, AmitGondro, Cedricda Silva Romero, Andrea Renata [UNESP]Karthikeyan, A.Mehrotra, ArnavPandey, A. K.Dutt, TriveniMishra, B. P.2022-04-28T19:40:19Z2022-04-28T19:40:19Z2021-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s11250-021-02795-zTropical Animal Health and Production, v. 53, n. 3, 2021.1573-74380049-4747http://hdl.handle.net/11449/22176910.1007/s11250-021-02795-z2-s2.0-85107336348Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTropical Animal Health and Productioninfo:eu-repo/semantics/openAccess2022-04-28T19:40:19Zoai:repositorio.unesp.br:11449/221769Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:48:05.917818Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
title |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
spellingShingle |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip Singh, Akansha Composite cattle Genome-wide association studies Milk fatty acid Vrindavani cattle |
title_short |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
title_full |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
title_fullStr |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
title_full_unstemmed |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
title_sort |
Identification of genes affecting milk fat and fatty acid composition in Vrindavani crossbred cattle using 50 K SNP-Chip |
author |
Singh, Akansha |
author_facet |
Singh, Akansha Kumar, Amit Gondro, Cedric da Silva Romero, Andrea Renata [UNESP] Karthikeyan, A. Mehrotra, Arnav Pandey, A. K. Dutt, Triveni Mishra, B. P. |
author_role |
author |
author2 |
Kumar, Amit Gondro, Cedric da Silva Romero, Andrea Renata [UNESP] Karthikeyan, A. Mehrotra, Arnav Pandey, A. K. Dutt, Triveni Mishra, B. P. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
ICAR-Indian Veterinary Research Institute Michigan State University Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Singh, Akansha Kumar, Amit Gondro, Cedric da Silva Romero, Andrea Renata [UNESP] Karthikeyan, A. Mehrotra, Arnav Pandey, A. K. Dutt, Triveni Mishra, B. P. |
dc.subject.por.fl_str_mv |
Composite cattle Genome-wide association studies Milk fatty acid Vrindavani cattle |
topic |
Composite cattle Genome-wide association studies Milk fatty acid Vrindavani cattle |
description |
The aim of this study was to identify candidate genes associated with milk fat per cent and fatty acid (FA) composition in Vrindavani cattle using the Illumina 50 K single-nucleotide polymorphism (SNP) array. After quality control, a total of 41,427 informative and high-quality SNPs were used for a genome-wide association study (GWAS) for milk fat percentage and 16 different types of fatty acids. Lactation stage, parity, test day milk yield, and proportion of exotic inheritance were included as fixed effects in the GWAS model. A total of 67 genome-wide significant (P < 1.20 × 10−06) SNPs and 176 suggestive significant (P < 2.41 × 10−05) SNPs were identified. Out of these, 15 SNPs were associated with more than one trait. The strongest associations were found on BTA14 for milk fat percentage and on BTA2 and BTA16 for polyunsaturated fatty acids. Several significant SNPs were identified close to or within the genes ELOVL6, FABP4, PMP2, PLIN1, MFGE8, GHRL2, and LDLRAD3 which are known to be associated with fat percentage and FA composition in dairy cattle breeds. This study is a step forward to better characterize the molecular mechanisms of phenotypic variation in milk fatty acids in a taurine–indicine composite cattle breed reared in tropical environments. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-01 2022-04-28T19:40:19Z 2022-04-28T19:40:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11250-021-02795-z Tropical Animal Health and Production, v. 53, n. 3, 2021. 1573-7438 0049-4747 http://hdl.handle.net/11449/221769 10.1007/s11250-021-02795-z 2-s2.0-85107336348 |
url |
http://dx.doi.org/10.1007/s11250-021-02795-z http://hdl.handle.net/11449/221769 |
identifier_str_mv |
Tropical Animal Health and Production, v. 53, n. 3, 2021. 1573-7438 0049-4747 10.1007/s11250-021-02795-z 2-s2.0-85107336348 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tropical Animal Health and Production |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129250185707520 |