Kavalactones and benzoic acid derivatives from leaves of piper fuligineum kunth (Piperaceae)

• Autor(a) principal: Mazzeu, Bruna F. [UNESP]
• Data de Publicação: 2018
• Outros Autores: Felippe, Lidiane G. [UNESP], Cotinguiba, Fernando, Kato, Massuo J., Furlan, Maysa [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.21577/0103-5053.20170225; http://hdl.handle.net/11449/179829
• topic: Benzoic acid derivatives; Kavalactones; Piper fuligineum; Piperaceae

The known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy-6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran-2-one, the three benzoic acid derivatives methyl-4-methoxy-3-(3’-methyl-2’-butenyl)benzoate and methyl 2,2-dimethyl-4-oxochroman-6-carboxylate, and a new methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate were isolated from the ethanolic extract of Piper fuligineum. The structures of these compounds were determined by using a combination of spectroscopic methods, including 1D- and 2D-nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. This is the first report of the chemical study of P. fuligineum, and the methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate is described as a new natural product.