Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jvim.15612 http://hdl.handle.net/11449/199530 |
Resumo: | Background: Symmetric dimethylarginine (SDMA) is a methylated arginine derived from intranuclear methylation of l-arginine by protein-arginine methyltransferase and released into circulation after proteolysis. It is primarily eliminated by renal excretion, and its concentration is highly correlated with glomerular filtration rate (GFR) in animals and humans and is an earlier indicator of kidney dysfunction than serum creatinine concentration (sCr). Objectives: To evaluate and quantify the effects of IV fluid therapy (IF) or intermittent hemodialysis (IH) on renal function in a randomized group of dogs previously diagnosed with International Renal Interest Society (IRIS) stage 4 chronic kidney disease (CKD). Animals: Twenty-four client-owned dogs with naturally occurring CKD. Methods: Serum from 14 dogs treated by IH and 10 dogs treated with IF was submitted for measurement of sCr and SDMA. Dogs in each treatment group received up to 5 treatment sessions, administered 48 hours apart. Results: Significant differences (P ≤.05) were seen between treatment groups, but dogs from the IH group were the most affected based on SDMA (P <.001), sCr (P <.001), and blood urea (P <.001) concentrations. Furthermore, for each 10% increase in urea reduction ratio, there was a 6.2 μg/dL decrease in SDMA (P =.002). Conclusions and Clinical Importance: Although SDMA is dialyzable biomarker and despite its removal by IH, SDMA correlates better with renal function than does sCr in dogs with CKD undergoing IF and IH. |
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spelling |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysiscaninedialysisglomerular filtration rateSDMA renal biomarkerBackground: Symmetric dimethylarginine (SDMA) is a methylated arginine derived from intranuclear methylation of l-arginine by protein-arginine methyltransferase and released into circulation after proteolysis. It is primarily eliminated by renal excretion, and its concentration is highly correlated with glomerular filtration rate (GFR) in animals and humans and is an earlier indicator of kidney dysfunction than serum creatinine concentration (sCr). Objectives: To evaluate and quantify the effects of IV fluid therapy (IF) or intermittent hemodialysis (IH) on renal function in a randomized group of dogs previously diagnosed with International Renal Interest Society (IRIS) stage 4 chronic kidney disease (CKD). Animals: Twenty-four client-owned dogs with naturally occurring CKD. Methods: Serum from 14 dogs treated by IH and 10 dogs treated with IF was submitted for measurement of sCr and SDMA. Dogs in each treatment group received up to 5 treatment sessions, administered 48 hours apart. Results: Significant differences (P ≤.05) were seen between treatment groups, but dogs from the IH group were the most affected based on SDMA (P <.001), sCr (P <.001), and blood urea (P <.001) concentrations. Furthermore, for each 10% increase in urea reduction ratio, there was a 6.2 μg/dL decrease in SDMA (P =.002). Conclusions and Clinical Importance: Although SDMA is dialyzable biomarker and despite its removal by IH, SDMA correlates better with renal function than does sCr in dogs with CKD undergoing IF and IH.Department of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University—UNESPIDEXX Laboratories IncDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University—UNESPUniversidade Estadual Paulista (Unesp)IDEXX Laboratories IncLe Sueur, André Nanny Vieira [UNESP]Geraldes, Silvano Salgueiro [UNESP]Melchert, Alessandra [UNESP]Takahira, Regina Kiomi [UNESP]Coyne, MichaelMurphy, RachelSzlosek, DonaldGuimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]2020-12-12T01:42:27Z2020-12-12T01:42:27Z2019-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2635-2643http://dx.doi.org/10.1111/jvim.15612Journal of Veterinary Internal Medicine, v. 33, n. 6, p. 2635-2643, 2019.1939-16760891-6640http://hdl.handle.net/11449/19953010.1111/jvim.156122-s2.0-85073769661Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Veterinary Internal Medicineinfo:eu-repo/semantics/openAccess2021-10-23T07:53:23Zoai:repositorio.unesp.br:11449/199530Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:13:20.450786Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
title |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
spellingShingle |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis Le Sueur, André Nanny Vieira [UNESP] canine dialysis glomerular filtration rate SDMA renal biomarker |
title_short |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
title_full |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
title_fullStr |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
title_full_unstemmed |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
title_sort |
Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis |
author |
Le Sueur, André Nanny Vieira [UNESP] |
author_facet |
Le Sueur, André Nanny Vieira [UNESP] Geraldes, Silvano Salgueiro [UNESP] Melchert, Alessandra [UNESP] Takahira, Regina Kiomi [UNESP] Coyne, Michael Murphy, Rachel Szlosek, Donald Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
author_role |
author |
author2 |
Geraldes, Silvano Salgueiro [UNESP] Melchert, Alessandra [UNESP] Takahira, Regina Kiomi [UNESP] Coyne, Michael Murphy, Rachel Szlosek, Donald Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) IDEXX Laboratories Inc |
dc.contributor.author.fl_str_mv |
Le Sueur, André Nanny Vieira [UNESP] Geraldes, Silvano Salgueiro [UNESP] Melchert, Alessandra [UNESP] Takahira, Regina Kiomi [UNESP] Coyne, Michael Murphy, Rachel Szlosek, Donald Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
dc.subject.por.fl_str_mv |
canine dialysis glomerular filtration rate SDMA renal biomarker |
topic |
canine dialysis glomerular filtration rate SDMA renal biomarker |
description |
Background: Symmetric dimethylarginine (SDMA) is a methylated arginine derived from intranuclear methylation of l-arginine by protein-arginine methyltransferase and released into circulation after proteolysis. It is primarily eliminated by renal excretion, and its concentration is highly correlated with glomerular filtration rate (GFR) in animals and humans and is an earlier indicator of kidney dysfunction than serum creatinine concentration (sCr). Objectives: To evaluate and quantify the effects of IV fluid therapy (IF) or intermittent hemodialysis (IH) on renal function in a randomized group of dogs previously diagnosed with International Renal Interest Society (IRIS) stage 4 chronic kidney disease (CKD). Animals: Twenty-four client-owned dogs with naturally occurring CKD. Methods: Serum from 14 dogs treated by IH and 10 dogs treated with IF was submitted for measurement of sCr and SDMA. Dogs in each treatment group received up to 5 treatment sessions, administered 48 hours apart. Results: Significant differences (P ≤.05) were seen between treatment groups, but dogs from the IH group were the most affected based on SDMA (P <.001), sCr (P <.001), and blood urea (P <.001) concentrations. Furthermore, for each 10% increase in urea reduction ratio, there was a 6.2 μg/dL decrease in SDMA (P =.002). Conclusions and Clinical Importance: Although SDMA is dialyzable biomarker and despite its removal by IH, SDMA correlates better with renal function than does sCr in dogs with CKD undergoing IF and IH. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-01 2020-12-12T01:42:27Z 2020-12-12T01:42:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jvim.15612 Journal of Veterinary Internal Medicine, v. 33, n. 6, p. 2635-2643, 2019. 1939-1676 0891-6640 http://hdl.handle.net/11449/199530 10.1111/jvim.15612 2-s2.0-85073769661 |
url |
http://dx.doi.org/10.1111/jvim.15612 http://hdl.handle.net/11449/199530 |
identifier_str_mv |
Journal of Veterinary Internal Medicine, v. 33, n. 6, p. 2635-2643, 2019. 1939-1676 0891-6640 10.1111/jvim.15612 2-s2.0-85073769661 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Veterinary Internal Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2635-2643 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128483344252928 |