Botulinum toxin as a treatment for short bowel syndrome in rats

Detalhes bibliográficos
Autor(a) principal: Marques, Isabela Cristina De Souza
Data de Publicação: 2019
Outros Autores: Minto, Stefânia Bovo, Marques, Mariane Quaglio, Ribeiro, Juliana, Moraes, Paola Castro, Sbragia Neto, Lourenço, Garcia, Sérgio Britto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/s0102-865020190070000005
http://hdl.handle.net/11449/183738
Resumo: AbstractPurpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion: This may provide a new promising approach to the surgical treatment of SBS.
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spelling Botulinum toxin as a treatment for short bowel syndrome in ratsShort Bowel SyndromeBotulinum ToxinsIleumRatsAbstractPurpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion: This may provide a new promising approach to the surgical treatment of SBS.Universidade de São Paulo School of Medicine of Ribeirao Preto Department of Pathology and Legal MedicineUSP School of Medicine of Ribeirao Preto Department of Pathology and Legal MedicineUniversidade Estadual Paulista Faculty of Veterinary Medicine Postgraduate Program in Veterinary SurgeryUNESP Faculty of Veterinary MedicineUSP School of Medicine of Ribeirao Preto Department of Surgery and AnatomyUniversidade Estadual Paulista Faculty of Veterinary Medicine Postgraduate Program in Veterinary SurgeryUNESP Faculty of Veterinary MedicineSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Marques, Isabela Cristina De SouzaMinto, Stefânia BovoMarques, Mariane QuaglioRibeiro, JulianaMoraes, Paola CastroSbragia Neto, LourençoGarcia, Sérgio Britto2019-10-03T17:31:26Z2019-10-03T17:31:26Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article-application/pdfhttp://dx.doi.org/10.1590/s0102-865020190070000005Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 34, n. 7, p. -, 2019.0102-8650http://hdl.handle.net/11449/18373810.1590/s0102-865020190070000005S0102-86502019000700206S0102-86502019000700206.pdf9956383349362446SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccess2023-10-06T06:08:39Zoai:repositorio.unesp.br:11449/183738Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:11:15.395045Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Botulinum toxin as a treatment for short bowel syndrome in rats
title Botulinum toxin as a treatment for short bowel syndrome in rats
spellingShingle Botulinum toxin as a treatment for short bowel syndrome in rats
Marques, Isabela Cristina De Souza
Short Bowel Syndrome
Botulinum Toxins
Ileum
Rats
title_short Botulinum toxin as a treatment for short bowel syndrome in rats
title_full Botulinum toxin as a treatment for short bowel syndrome in rats
title_fullStr Botulinum toxin as a treatment for short bowel syndrome in rats
title_full_unstemmed Botulinum toxin as a treatment for short bowel syndrome in rats
title_sort Botulinum toxin as a treatment for short bowel syndrome in rats
author Marques, Isabela Cristina De Souza
author_facet Marques, Isabela Cristina De Souza
Minto, Stefânia Bovo
Marques, Mariane Quaglio
Ribeiro, Juliana
Moraes, Paola Castro
Sbragia Neto, Lourenço
Garcia, Sérgio Britto
author_role author
author2 Minto, Stefânia Bovo
Marques, Mariane Quaglio
Ribeiro, Juliana
Moraes, Paola Castro
Sbragia Neto, Lourenço
Garcia, Sérgio Britto
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Marques, Isabela Cristina De Souza
Minto, Stefânia Bovo
Marques, Mariane Quaglio
Ribeiro, Juliana
Moraes, Paola Castro
Sbragia Neto, Lourenço
Garcia, Sérgio Britto
dc.subject.por.fl_str_mv Short Bowel Syndrome
Botulinum Toxins
Ileum
Rats
topic Short Bowel Syndrome
Botulinum Toxins
Ileum
Rats
description AbstractPurpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion: This may provide a new promising approach to the surgical treatment of SBS.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-03T17:31:26Z
2019-10-03T17:31:26Z
2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/s0102-865020190070000005
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 34, n. 7, p. -, 2019.
0102-8650
http://hdl.handle.net/11449/183738
10.1590/s0102-865020190070000005
S0102-86502019000700206
S0102-86502019000700206.pdf
9956383349362446
url http://dx.doi.org/10.1590/s0102-865020190070000005
http://hdl.handle.net/11449/183738
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 34, n. 7, p. -, 2019.
0102-8650
10.1590/s0102-865020190070000005
S0102-86502019000700206
S0102-86502019000700206.pdf
9956383349362446
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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