Botulinum toxin as a treatment for short bowel syndrome in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/s0102-865020190070000005 http://hdl.handle.net/11449/183738 |
Resumo: | AbstractPurpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion: This may provide a new promising approach to the surgical treatment of SBS. |
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Botulinum toxin as a treatment for short bowel syndrome in ratsShort Bowel SyndromeBotulinum ToxinsIleumRatsAbstractPurpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion: This may provide a new promising approach to the surgical treatment of SBS.Universidade de São Paulo School of Medicine of Ribeirao Preto Department of Pathology and Legal MedicineUSP School of Medicine of Ribeirao Preto Department of Pathology and Legal MedicineUniversidade Estadual Paulista Faculty of Veterinary Medicine Postgraduate Program in Veterinary SurgeryUNESP Faculty of Veterinary MedicineUSP School of Medicine of Ribeirao Preto Department of Surgery and AnatomyUniversidade Estadual Paulista Faculty of Veterinary Medicine Postgraduate Program in Veterinary SurgeryUNESP Faculty of Veterinary MedicineSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Marques, Isabela Cristina De SouzaMinto, Stefânia BovoMarques, Mariane QuaglioRibeiro, JulianaMoraes, Paola CastroSbragia Neto, LourençoGarcia, Sérgio Britto2019-10-03T17:31:26Z2019-10-03T17:31:26Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article-application/pdfhttp://dx.doi.org/10.1590/s0102-865020190070000005Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 34, n. 7, p. -, 2019.0102-8650http://hdl.handle.net/11449/18373810.1590/s0102-865020190070000005S0102-86502019000700206S0102-86502019000700206.pdf9956383349362446SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccess2023-10-06T06:08:39Zoai:repositorio.unesp.br:11449/183738Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:11:15.395045Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Botulinum toxin as a treatment for short bowel syndrome in rats |
title |
Botulinum toxin as a treatment for short bowel syndrome in rats |
spellingShingle |
Botulinum toxin as a treatment for short bowel syndrome in rats Marques, Isabela Cristina De Souza Short Bowel Syndrome Botulinum Toxins Ileum Rats |
title_short |
Botulinum toxin as a treatment for short bowel syndrome in rats |
title_full |
Botulinum toxin as a treatment for short bowel syndrome in rats |
title_fullStr |
Botulinum toxin as a treatment for short bowel syndrome in rats |
title_full_unstemmed |
Botulinum toxin as a treatment for short bowel syndrome in rats |
title_sort |
Botulinum toxin as a treatment for short bowel syndrome in rats |
author |
Marques, Isabela Cristina De Souza |
author_facet |
Marques, Isabela Cristina De Souza Minto, Stefânia Bovo Marques, Mariane Quaglio Ribeiro, Juliana Moraes, Paola Castro Sbragia Neto, Lourenço Garcia, Sérgio Britto |
author_role |
author |
author2 |
Minto, Stefânia Bovo Marques, Mariane Quaglio Ribeiro, Juliana Moraes, Paola Castro Sbragia Neto, Lourenço Garcia, Sérgio Britto |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Marques, Isabela Cristina De Souza Minto, Stefânia Bovo Marques, Mariane Quaglio Ribeiro, Juliana Moraes, Paola Castro Sbragia Neto, Lourenço Garcia, Sérgio Britto |
dc.subject.por.fl_str_mv |
Short Bowel Syndrome Botulinum Toxins Ileum Rats |
topic |
Short Bowel Syndrome Botulinum Toxins Ileum Rats |
description |
AbstractPurpose: The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods: Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results: We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion: This may provide a new promising approach to the surgical treatment of SBS. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-03T17:31:26Z 2019-10-03T17:31:26Z 2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s0102-865020190070000005 Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 34, n. 7, p. -, 2019. 0102-8650 http://hdl.handle.net/11449/183738 10.1590/s0102-865020190070000005 S0102-86502019000700206 S0102-86502019000700206.pdf 9956383349362446 |
url |
http://dx.doi.org/10.1590/s0102-865020190070000005 http://hdl.handle.net/11449/183738 |
identifier_str_mv |
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 34, n. 7, p. -, 2019. 0102-8650 10.1590/s0102-865020190070000005 S0102-86502019000700206 S0102-86502019000700206.pdf 9956383349362446 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128328952971264 |