Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.preghy.2022.05.002 http://hdl.handle.net/11449/241015 |
Resumo: | Hypertension is associated to impaired baroreflex sensitivity (BRS). In spontaneously hypertensive rats (SHR), pregnancy reduces blood pressure, and this effect has been associated to increase nitric oxide (NO) bioavailability. Increased NO bioavailability has been linked to improve BRS in hypertensive animals. Therefore, we hypothesize that pregnancy improves the BRS in SHR. We performed experiments to evaluate the vasomotor and cardiac autonomic modulation, also to evaluate the BRS at baseline conditions (spontaneous) and after phenylephrine (PE) and sodium nitroprusside (SNP) administrations in non-pregnant (NP) and pregnant (P) Wistar rats and SHR. Beat-to-beat time series with systolic arterial pressure values were generated and processed by Fast Fourier Transform (spectral analysis). Next, spectra were integrated into low-frequency (LF) band and had their power taken as an index of sympathetic modulation on arterial pressure. Reduced mean arterial pressure was observed in P-groups when compared to NP matched rats, although we did not observe alterations in heart rate (HR). In SHR-NP, spectral analysis revealed altered cardiovascular autonomic modulation when compared to the other groups. However, in SHR-P the autonomic parameters were similar to those observed in Wistar-NP, suggesting that pregnancy changed autonomic modulation. BRS assessed by means of the sequence method was found similar in P-groups. Pregnancy reduced the BRS during hypotension in Wistar. BRS assessed with PE and SNP administration was found lower in SHR-NP as compared to Wistar-NP, and it was not altered by pregnancy. In conclusion, pregnancy did not improve the BRS in SHR, but normalized altered sympathetic vasomotor modulation in SHR. |
id |
UNSP_78cffb55581f394992582170552febf7 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/241015 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive ratsBaroreflex sensitivityCardiac autonomic modulationHypertensionPregnancySHRHypertension is associated to impaired baroreflex sensitivity (BRS). In spontaneously hypertensive rats (SHR), pregnancy reduces blood pressure, and this effect has been associated to increase nitric oxide (NO) bioavailability. Increased NO bioavailability has been linked to improve BRS in hypertensive animals. Therefore, we hypothesize that pregnancy improves the BRS in SHR. We performed experiments to evaluate the vasomotor and cardiac autonomic modulation, also to evaluate the BRS at baseline conditions (spontaneous) and after phenylephrine (PE) and sodium nitroprusside (SNP) administrations in non-pregnant (NP) and pregnant (P) Wistar rats and SHR. Beat-to-beat time series with systolic arterial pressure values were generated and processed by Fast Fourier Transform (spectral analysis). Next, spectra were integrated into low-frequency (LF) band and had their power taken as an index of sympathetic modulation on arterial pressure. Reduced mean arterial pressure was observed in P-groups when compared to NP matched rats, although we did not observe alterations in heart rate (HR). In SHR-NP, spectral analysis revealed altered cardiovascular autonomic modulation when compared to the other groups. However, in SHR-P the autonomic parameters were similar to those observed in Wistar-NP, suggesting that pregnancy changed autonomic modulation. BRS assessed by means of the sequence method was found similar in P-groups. Pregnancy reduced the BRS during hypotension in Wistar. BRS assessed with PE and SNP administration was found lower in SHR-NP as compared to Wistar-NP, and it was not altered by pregnancy. In conclusion, pregnancy did not improve the BRS in SHR, but normalized altered sympathetic vasomotor modulation in SHR.Multicenter Graduate Program in Physiological Sciences SBFisDepartment of Basic Sciences School of Dentistry of Araçatuba São Paulo State University – UNESP, São PauloCurso de Medicina Faculdades de Dracena Fundação Dracenense de Educação e Cultura – UNIFADRA, São PauloMinas Gerais State University – UEMG, Minas GeraisBarão de Mauá University Center, São PauloDepartment of Basic Sciences School of Dentistry of Araçatuba São Paulo State University – UNESP, São PauloSBFisUniversidade Estadual Paulista (UNESP)Fundação Dracenense de Educação e Cultura – UNIFADRAUniversidade Estadual de Maringá (UEM)Barão de Mauá University CenterNatali, Luiz Henrique [UNESP]Troiano, Jéssica Antonini [UNESP]Potje, Simone Regina [UNESP]Dias, Daniel Penteado MartinsAntoniali, Cristina [UNESP]2023-03-01T20:43:16Z2023-03-01T20:43:16Z2022-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article180-188http://dx.doi.org/10.1016/j.preghy.2022.05.002Pregnancy Hypertension, v. 28, p. 180-188.2210-77972210-7789http://hdl.handle.net/11449/24101510.1016/j.preghy.2022.05.0022-s2.0-85130321996Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPregnancy Hypertensioninfo:eu-repo/semantics/openAccess2024-09-19T14:02:26Zoai:repositorio.unesp.br:11449/241015Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:02:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
title |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
spellingShingle |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats Natali, Luiz Henrique [UNESP] Baroreflex sensitivity Cardiac autonomic modulation Hypertension Pregnancy SHR |
title_short |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
title_full |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
title_fullStr |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
title_full_unstemmed |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
title_sort |
Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats |
author |
Natali, Luiz Henrique [UNESP] |
author_facet |
Natali, Luiz Henrique [UNESP] Troiano, Jéssica Antonini [UNESP] Potje, Simone Regina [UNESP] Dias, Daniel Penteado Martins Antoniali, Cristina [UNESP] |
author_role |
author |
author2 |
Troiano, Jéssica Antonini [UNESP] Potje, Simone Regina [UNESP] Dias, Daniel Penteado Martins Antoniali, Cristina [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
SBFis Universidade Estadual Paulista (UNESP) Fundação Dracenense de Educação e Cultura – UNIFADRA Universidade Estadual de Maringá (UEM) Barão de Mauá University Center |
dc.contributor.author.fl_str_mv |
Natali, Luiz Henrique [UNESP] Troiano, Jéssica Antonini [UNESP] Potje, Simone Regina [UNESP] Dias, Daniel Penteado Martins Antoniali, Cristina [UNESP] |
dc.subject.por.fl_str_mv |
Baroreflex sensitivity Cardiac autonomic modulation Hypertension Pregnancy SHR |
topic |
Baroreflex sensitivity Cardiac autonomic modulation Hypertension Pregnancy SHR |
description |
Hypertension is associated to impaired baroreflex sensitivity (BRS). In spontaneously hypertensive rats (SHR), pregnancy reduces blood pressure, and this effect has been associated to increase nitric oxide (NO) bioavailability. Increased NO bioavailability has been linked to improve BRS in hypertensive animals. Therefore, we hypothesize that pregnancy improves the BRS in SHR. We performed experiments to evaluate the vasomotor and cardiac autonomic modulation, also to evaluate the BRS at baseline conditions (spontaneous) and after phenylephrine (PE) and sodium nitroprusside (SNP) administrations in non-pregnant (NP) and pregnant (P) Wistar rats and SHR. Beat-to-beat time series with systolic arterial pressure values were generated and processed by Fast Fourier Transform (spectral analysis). Next, spectra were integrated into low-frequency (LF) band and had their power taken as an index of sympathetic modulation on arterial pressure. Reduced mean arterial pressure was observed in P-groups when compared to NP matched rats, although we did not observe alterations in heart rate (HR). In SHR-NP, spectral analysis revealed altered cardiovascular autonomic modulation when compared to the other groups. However, in SHR-P the autonomic parameters were similar to those observed in Wistar-NP, suggesting that pregnancy changed autonomic modulation. BRS assessed by means of the sequence method was found similar in P-groups. Pregnancy reduced the BRS during hypotension in Wistar. BRS assessed with PE and SNP administration was found lower in SHR-NP as compared to Wistar-NP, and it was not altered by pregnancy. In conclusion, pregnancy did not improve the BRS in SHR, but normalized altered sympathetic vasomotor modulation in SHR. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-01 2023-03-01T20:43:16Z 2023-03-01T20:43:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.preghy.2022.05.002 Pregnancy Hypertension, v. 28, p. 180-188. 2210-7797 2210-7789 http://hdl.handle.net/11449/241015 10.1016/j.preghy.2022.05.002 2-s2.0-85130321996 |
url |
http://dx.doi.org/10.1016/j.preghy.2022.05.002 http://hdl.handle.net/11449/241015 |
identifier_str_mv |
Pregnancy Hypertension, v. 28, p. 180-188. 2210-7797 2210-7789 10.1016/j.preghy.2022.05.002 2-s2.0-85130321996 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pregnancy Hypertension |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
180-188 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546379505565696 |