Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats

Detalhes bibliográficos
Autor(a) principal: Natali, Luiz Henrique [UNESP]
Data de Publicação: 2022
Outros Autores: Troiano, Jéssica Antonini [UNESP], Potje, Simone Regina [UNESP], Dias, Daniel Penteado Martins, Antoniali, Cristina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.preghy.2022.05.002
http://hdl.handle.net/11449/241015
Resumo: Hypertension is associated to impaired baroreflex sensitivity (BRS). In spontaneously hypertensive rats (SHR), pregnancy reduces blood pressure, and this effect has been associated to increase nitric oxide (NO) bioavailability. Increased NO bioavailability has been linked to improve BRS in hypertensive animals. Therefore, we hypothesize that pregnancy improves the BRS in SHR. We performed experiments to evaluate the vasomotor and cardiac autonomic modulation, also to evaluate the BRS at baseline conditions (spontaneous) and after phenylephrine (PE) and sodium nitroprusside (SNP) administrations in non-pregnant (NP) and pregnant (P) Wistar rats and SHR. Beat-to-beat time series with systolic arterial pressure values were generated and processed by Fast Fourier Transform (spectral analysis). Next, spectra were integrated into low-frequency (LF) band and had their power taken as an index of sympathetic modulation on arterial pressure. Reduced mean arterial pressure was observed in P-groups when compared to NP matched rats, although we did not observe alterations in heart rate (HR). In SHR-NP, spectral analysis revealed altered cardiovascular autonomic modulation when compared to the other groups. However, in SHR-P the autonomic parameters were similar to those observed in Wistar-NP, suggesting that pregnancy changed autonomic modulation. BRS assessed by means of the sequence method was found similar in P-groups. Pregnancy reduced the BRS during hypotension in Wistar. BRS assessed with PE and SNP administration was found lower in SHR-NP as compared to Wistar-NP, and it was not altered by pregnancy. In conclusion, pregnancy did not improve the BRS in SHR, but normalized altered sympathetic vasomotor modulation in SHR.
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spelling Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive ratsBaroreflex sensitivityCardiac autonomic modulationHypertensionPregnancySHRHypertension is associated to impaired baroreflex sensitivity (BRS). In spontaneously hypertensive rats (SHR), pregnancy reduces blood pressure, and this effect has been associated to increase nitric oxide (NO) bioavailability. Increased NO bioavailability has been linked to improve BRS in hypertensive animals. Therefore, we hypothesize that pregnancy improves the BRS in SHR. We performed experiments to evaluate the vasomotor and cardiac autonomic modulation, also to evaluate the BRS at baseline conditions (spontaneous) and after phenylephrine (PE) and sodium nitroprusside (SNP) administrations in non-pregnant (NP) and pregnant (P) Wistar rats and SHR. Beat-to-beat time series with systolic arterial pressure values were generated and processed by Fast Fourier Transform (spectral analysis). Next, spectra were integrated into low-frequency (LF) band and had their power taken as an index of sympathetic modulation on arterial pressure. Reduced mean arterial pressure was observed in P-groups when compared to NP matched rats, although we did not observe alterations in heart rate (HR). In SHR-NP, spectral analysis revealed altered cardiovascular autonomic modulation when compared to the other groups. However, in SHR-P the autonomic parameters were similar to those observed in Wistar-NP, suggesting that pregnancy changed autonomic modulation. BRS assessed by means of the sequence method was found similar in P-groups. Pregnancy reduced the BRS during hypotension in Wistar. BRS assessed with PE and SNP administration was found lower in SHR-NP as compared to Wistar-NP, and it was not altered by pregnancy. In conclusion, pregnancy did not improve the BRS in SHR, but normalized altered sympathetic vasomotor modulation in SHR.Multicenter Graduate Program in Physiological Sciences SBFisDepartment of Basic Sciences School of Dentistry of Araçatuba São Paulo State University – UNESP, São PauloCurso de Medicina Faculdades de Dracena Fundação Dracenense de Educação e Cultura – UNIFADRA, São PauloMinas Gerais State University – UEMG, Minas GeraisBarão de Mauá University Center, São PauloDepartment of Basic Sciences School of Dentistry of Araçatuba São Paulo State University – UNESP, São PauloSBFisUniversidade Estadual Paulista (UNESP)Fundação Dracenense de Educação e Cultura – UNIFADRAUniversidade Estadual de Maringá (UEM)Barão de Mauá University CenterNatali, Luiz Henrique [UNESP]Troiano, Jéssica Antonini [UNESP]Potje, Simone Regina [UNESP]Dias, Daniel Penteado MartinsAntoniali, Cristina [UNESP]2023-03-01T20:43:16Z2023-03-01T20:43:16Z2022-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article180-188http://dx.doi.org/10.1016/j.preghy.2022.05.002Pregnancy Hypertension, v. 28, p. 180-188.2210-77972210-7789http://hdl.handle.net/11449/24101510.1016/j.preghy.2022.05.0022-s2.0-85130321996Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPregnancy Hypertensioninfo:eu-repo/semantics/openAccess2024-09-19T14:02:26Zoai:repositorio.unesp.br:11449/241015Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:02:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
title Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
spellingShingle Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
Natali, Luiz Henrique [UNESP]
Baroreflex sensitivity
Cardiac autonomic modulation
Hypertension
Pregnancy
SHR
title_short Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
title_full Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
title_fullStr Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
title_full_unstemmed Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
title_sort Pregnancy restores altered sympathetic vasomotor modulation and parasympathetic cardiac modulation in hypertensive rats
author Natali, Luiz Henrique [UNESP]
author_facet Natali, Luiz Henrique [UNESP]
Troiano, Jéssica Antonini [UNESP]
Potje, Simone Regina [UNESP]
Dias, Daniel Penteado Martins
Antoniali, Cristina [UNESP]
author_role author
author2 Troiano, Jéssica Antonini [UNESP]
Potje, Simone Regina [UNESP]
Dias, Daniel Penteado Martins
Antoniali, Cristina [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv SBFis
Universidade Estadual Paulista (UNESP)
Fundação Dracenense de Educação e Cultura – UNIFADRA
Universidade Estadual de Maringá (UEM)
Barão de Mauá University Center
dc.contributor.author.fl_str_mv Natali, Luiz Henrique [UNESP]
Troiano, Jéssica Antonini [UNESP]
Potje, Simone Regina [UNESP]
Dias, Daniel Penteado Martins
Antoniali, Cristina [UNESP]
dc.subject.por.fl_str_mv Baroreflex sensitivity
Cardiac autonomic modulation
Hypertension
Pregnancy
SHR
topic Baroreflex sensitivity
Cardiac autonomic modulation
Hypertension
Pregnancy
SHR
description Hypertension is associated to impaired baroreflex sensitivity (BRS). In spontaneously hypertensive rats (SHR), pregnancy reduces blood pressure, and this effect has been associated to increase nitric oxide (NO) bioavailability. Increased NO bioavailability has been linked to improve BRS in hypertensive animals. Therefore, we hypothesize that pregnancy improves the BRS in SHR. We performed experiments to evaluate the vasomotor and cardiac autonomic modulation, also to evaluate the BRS at baseline conditions (spontaneous) and after phenylephrine (PE) and sodium nitroprusside (SNP) administrations in non-pregnant (NP) and pregnant (P) Wistar rats and SHR. Beat-to-beat time series with systolic arterial pressure values were generated and processed by Fast Fourier Transform (spectral analysis). Next, spectra were integrated into low-frequency (LF) band and had their power taken as an index of sympathetic modulation on arterial pressure. Reduced mean arterial pressure was observed in P-groups when compared to NP matched rats, although we did not observe alterations in heart rate (HR). In SHR-NP, spectral analysis revealed altered cardiovascular autonomic modulation when compared to the other groups. However, in SHR-P the autonomic parameters were similar to those observed in Wistar-NP, suggesting that pregnancy changed autonomic modulation. BRS assessed by means of the sequence method was found similar in P-groups. Pregnancy reduced the BRS during hypotension in Wistar. BRS assessed with PE and SNP administration was found lower in SHR-NP as compared to Wistar-NP, and it was not altered by pregnancy. In conclusion, pregnancy did not improve the BRS in SHR, but normalized altered sympathetic vasomotor modulation in SHR.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-01
2023-03-01T20:43:16Z
2023-03-01T20:43:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.preghy.2022.05.002
Pregnancy Hypertension, v. 28, p. 180-188.
2210-7797
2210-7789
http://hdl.handle.net/11449/241015
10.1016/j.preghy.2022.05.002
2-s2.0-85130321996
url http://dx.doi.org/10.1016/j.preghy.2022.05.002
http://hdl.handle.net/11449/241015
identifier_str_mv Pregnancy Hypertension, v. 28, p. 180-188.
2210-7797
2210-7789
10.1016/j.preghy.2022.05.002
2-s2.0-85130321996
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pregnancy Hypertension
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 180-188
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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