Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo

Detalhes bibliográficos
Autor(a) principal: Marques Meccatti, Vanessa [UNESP]
Data de Publicação: 2022
Outros Autores: De Souza Moura, Larissa [UNESP], Guerra Pinto, Juliana, Ferreira-Strixino, Juliana, Abu Hasna, Amjad [UNESP], Alves Figueiredo-Godoi, Lívia Mara [UNESP], Campos Junqueira, Juliana [UNESP], Marcucci, Maria Cristina [UNESP], Paula Ramos, Lucas De [UNESP], Carvalho, Claudio Antonio Talge [UNESP], Pucci, Cesar Rogério [UNESP], De Oliveira, Luciane Dias [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2022/5837864
http://hdl.handle.net/11449/241335
Resumo: Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes LEDon Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.
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spelling Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In VivoRadiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes LEDon Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.Department Of Biosciences And Oral Diagnosis Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos CamposPhotobiology Applied To Health (PHOTOBIOS)-University Of Vale Do Paraiba Research And Development Institute São José Dos Campos, Av. Shishima Hifumi, 2911Department Of Restorative Dentistry Endodontics Division Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos CamposDepartment Of Restorative Dentistry Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos CamposDepartment Of Biosciences And Oral Diagnosis Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos CamposDepartment Of Restorative Dentistry Endodontics Division Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos CamposDepartment Of Restorative Dentistry Institute Of Science And Technology São Paulo State University (ICT-UNESP) São José Dos CamposUniversidade Estadual Paulista (UNESP)São José Dos CamposMarques Meccatti, Vanessa [UNESP]De Souza Moura, Larissa [UNESP]Guerra Pinto, JulianaFerreira-Strixino, JulianaAbu Hasna, Amjad [UNESP]Alves Figueiredo-Godoi, Lívia Mara [UNESP]Campos Junqueira, Juliana [UNESP]Marcucci, Maria Cristina [UNESP]Paula Ramos, Lucas De [UNESP]Carvalho, Claudio Antonio Talge [UNESP]Pucci, Cesar Rogério [UNESP]De Oliveira, Luciane Dias [UNESP]2023-03-01T20:57:24Z2023-03-01T20:57:24Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2022/5837864International Journal of Dentistry, v. 2022.1687-87361687-8728http://hdl.handle.net/11449/24133510.1155/2022/58378642-s2.0-85134153607Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Dentistryinfo:eu-repo/semantics/openAccess2023-03-01T20:57:24Zoai:repositorio.unesp.br:11449/241335Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:48:04.996263Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
title Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
spellingShingle Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
Marques Meccatti, Vanessa [UNESP]
title_short Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
title_full Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
title_fullStr Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
title_full_unstemmed Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
title_sort Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
author Marques Meccatti, Vanessa [UNESP]
author_facet Marques Meccatti, Vanessa [UNESP]
De Souza Moura, Larissa [UNESP]
Guerra Pinto, Juliana
Ferreira-Strixino, Juliana
Abu Hasna, Amjad [UNESP]
Alves Figueiredo-Godoi, Lívia Mara [UNESP]
Campos Junqueira, Juliana [UNESP]
Marcucci, Maria Cristina [UNESP]
Paula Ramos, Lucas De [UNESP]
Carvalho, Claudio Antonio Talge [UNESP]
Pucci, Cesar Rogério [UNESP]
De Oliveira, Luciane Dias [UNESP]
author_role author
author2 De Souza Moura, Larissa [UNESP]
Guerra Pinto, Juliana
Ferreira-Strixino, Juliana
Abu Hasna, Amjad [UNESP]
Alves Figueiredo-Godoi, Lívia Mara [UNESP]
Campos Junqueira, Juliana [UNESP]
Marcucci, Maria Cristina [UNESP]
Paula Ramos, Lucas De [UNESP]
Carvalho, Claudio Antonio Talge [UNESP]
Pucci, Cesar Rogério [UNESP]
De Oliveira, Luciane Dias [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
São José Dos Campos
dc.contributor.author.fl_str_mv Marques Meccatti, Vanessa [UNESP]
De Souza Moura, Larissa [UNESP]
Guerra Pinto, Juliana
Ferreira-Strixino, Juliana
Abu Hasna, Amjad [UNESP]
Alves Figueiredo-Godoi, Lívia Mara [UNESP]
Campos Junqueira, Juliana [UNESP]
Marcucci, Maria Cristina [UNESP]
Paula Ramos, Lucas De [UNESP]
Carvalho, Claudio Antonio Talge [UNESP]
Pucci, Cesar Rogério [UNESP]
De Oliveira, Luciane Dias [UNESP]
description Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes LEDon Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T20:57:24Z
2023-03-01T20:57:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2022/5837864
International Journal of Dentistry, v. 2022.
1687-8736
1687-8728
http://hdl.handle.net/11449/241335
10.1155/2022/5837864
2-s2.0-85134153607
url http://dx.doi.org/10.1155/2022/5837864
http://hdl.handle.net/11449/241335
identifier_str_mv International Journal of Dentistry, v. 2022.
1687-8736
1687-8728
10.1155/2022/5837864
2-s2.0-85134153607
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Dentistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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