COVID-19 in a patient with liver cirrhosis

• Autor(a) principal: Beraldo, Rodrigo Fedatto [UNESP]
• Data de Publicação: 2021
• Outros Autores: Marcondes, Mariana Barros [UNESP], Dos Santos, Maria Natália Marques, Grillo, Thais Gagno [UNESP], Pires, Gabriel Barros Tambelli [UNESP], de Oliveira, Cássio Vieira [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.12659/AJCR.929948; http://hdl.handle.net/11449/207407
• topic: COVID-19; Liver; Liver Cirrhosis; Liver Diseases; SARS Virus

Objective: Background: Case Report: Conclusions: Unusual clinical course The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which manifests mainly as a respiratory condition, has become a global pandemic that causes coronavirus disease-2019 (COVID-19). Although the symptoms remain mild in most patients, the elderly and patients with previous comorbidities have higher rates of morbidity and mortality. Patients with liver cirrhosis, especially after decompensation, may be more suscep-tible to SARS-CoV-2 infection due to systemic immune dysfunction. The patient was a 51-year-old man who was hypertensive, an ex-alcoholic abstinent for 6 months, and a smok-er. He was diagnosed with alcoholic liver cirrhosis in July 2019, and was using norfloxacin at home for secondary prophylaxis of bacterial peritonitis. He was also using furosemide and spironolactone to control ascites and propranolol for primary prophylaxis of esophageal varices. The patient entered our hospital in July 2020 with cough, dyspnea, runny nose, diarrhea, and fever. During hospitalization, we confirmed infection by COVID-19 and secondary nosocomial pulmonary infection. Chest tomography compatible with ground-glass standard was performed. The patient developed the need for auxiliary oxygen but without invasive mechanical venti-lation. The patient received dexamethasone 6 mg/day and broad-spectrum antibiotic therapy (he was started on cefepime but switched to meropenem). At the end of the 14-day isolation period, he was discharged with improved respiratory status. Despite high mortality rates in patients with advanced cirrhosis who become infected with COVID-19, we report a case with a favorable outcome. Success has been achieved with the use of medications in studies of broad-spectrum antibiotics and the rapid detection of complications caused by the virus. Further studies in SARS-CoV-2 patients with chronic liver disease are needed.