Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies

Detalhes bibliográficos
Autor(a) principal: Cazedey, Edith Cristina Laignier [UNESP]
Data de Publicação: 2014
Outros Autores: Salgado, Hérida Regina Nunes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300457&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/130161
Resumo: New, simple and cost effective UV-spectrophotometric method was developed for the estimation of orbifloxacin in pharmaceutical formulation. Orbifloxacin was estimated at 290 nm in 0.5 M hydrochloric acid. Linearity range was found to be 1.0-6.0 mu g mL(-1). The method was tested and validated for various parameters according to main guidelines. The proposed method was successfully applied for the determination of orbifloxacin in tablets. The results demonstrated that the procedure is accurate, precise and reproducible, while being simple, economical and less time consuming. It can be suitably applied for the estimation of orbifloxacin in routine quality control and dissolution studies.
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spelling Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studiesMedicines/quality controlMedicines/dissolutionOrbifloxacin/determinationUV spectrophotometry/quantitative analysis/validationMedicamentos/controle de qualidadeMedicamentos/dissoluçãoMétodo analíticoOrbifloxacino/determinaçãoEspectrofotometria na região do UV/controle de qualidade/validaçãoNew, simple and cost effective UV-spectrophotometric method was developed for the estimation of orbifloxacin in pharmaceutical formulation. Orbifloxacin was estimated at 290 nm in 0.5 M hydrochloric acid. Linearity range was found to be 1.0-6.0 mu g mL(-1). The method was tested and validated for various parameters according to main guidelines. The proposed method was successfully applied for the determination of orbifloxacin in tablets. The results demonstrated that the procedure is accurate, precise and reproducible, while being simple, economical and less time consuming. It can be suitably applied for the estimation of orbifloxacin in routine quality control and dissolution studies.Um método espectrofotométrico novo, simples e de baixo custo foi desenvolvido para a determinação de orbifloxacino em formulação farmacêutica. O orbifloxacino foi determinado em 290 nm utilizando ácido clorídrico 0,5 M como solvente. O intervalo de linearidade usado foi de 1,0 a 6,0 μg mL–1. O método foi testado e validado em vários parâmetros de acordo com os principais guias. O método proposto foi aplicado com sucesso para a determinação de orbifloxacino em comprimidos. Os resultados demonstraram que este procedimento é exato, preciso e reprodutível, ao mesmo tempo em que é simples, barato e de mais rápida execução e pode ser adequadamente aplicado para a determinação de orbifloxacino na rotina do controle de qualidade e em estudos de dissolução de comprimidos contendo este fármaco.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual Paulista, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de AraraquaraUniv Sao Paulo, Conjunto QuimicasUniversidade Estadual Paulista (Unesp)Cazedey, Edith Cristina Laignier [UNESP]Salgado, Hérida Regina Nunes [UNESP]2015-11-03T15:29:46Z2015-11-03T15:29:46Z2014-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article457-465application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300457&lng=en&nrm=iso&tlng=enBrazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 457-465, 2014.1984-8250http://hdl.handle.net/11449/13016110.1590/S1984-82502014000300003S1984-82502014000300457WOS:000345428300003S1984-82502014000300457.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal Of Pharmaceutical Sciences0.4830,214info:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/130161Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:46:17.868816Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
title Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
spellingShingle Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
Cazedey, Edith Cristina Laignier [UNESP]
Medicines/quality control
Medicines/dissolution
Orbifloxacin/determination
UV spectrophotometry/quantitative analysis/validation
Medicamentos/controle de qualidade
Medicamentos/dissolução
Método analítico
Orbifloxacino/determinação
Espectrofotometria na região do UV/controle de qualidade/validação
title_short Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
title_full Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
title_fullStr Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
title_full_unstemmed Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
title_sort Development and validation of UV spectrophotometric method for orbifloxacin assay and dissolution studies
author Cazedey, Edith Cristina Laignier [UNESP]
author_facet Cazedey, Edith Cristina Laignier [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
author_role author
author2 Salgado, Hérida Regina Nunes [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Cazedey, Edith Cristina Laignier [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
dc.subject.por.fl_str_mv Medicines/quality control
Medicines/dissolution
Orbifloxacin/determination
UV spectrophotometry/quantitative analysis/validation
Medicamentos/controle de qualidade
Medicamentos/dissolução
Método analítico
Orbifloxacino/determinação
Espectrofotometria na região do UV/controle de qualidade/validação
topic Medicines/quality control
Medicines/dissolution
Orbifloxacin/determination
UV spectrophotometry/quantitative analysis/validation
Medicamentos/controle de qualidade
Medicamentos/dissolução
Método analítico
Orbifloxacino/determinação
Espectrofotometria na região do UV/controle de qualidade/validação
description New, simple and cost effective UV-spectrophotometric method was developed for the estimation of orbifloxacin in pharmaceutical formulation. Orbifloxacin was estimated at 290 nm in 0.5 M hydrochloric acid. Linearity range was found to be 1.0-6.0 mu g mL(-1). The method was tested and validated for various parameters according to main guidelines. The proposed method was successfully applied for the determination of orbifloxacin in tablets. The results demonstrated that the procedure is accurate, precise and reproducible, while being simple, economical and less time consuming. It can be suitably applied for the estimation of orbifloxacin in routine quality control and dissolution studies.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
2015-11-03T15:29:46Z
2015-11-03T15:29:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300457&lng=en&nrm=iso&tlng=en
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 457-465, 2014.
1984-8250
http://hdl.handle.net/11449/130161
10.1590/S1984-82502014000300003
S1984-82502014000300457
WOS:000345428300003
S1984-82502014000300457.pdf
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300457&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/130161
identifier_str_mv Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 50, n. 3, p. 457-465, 2014.
1984-8250
10.1590/S1984-82502014000300003
S1984-82502014000300457
WOS:000345428300003
S1984-82502014000300457.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal Of Pharmaceutical Sciences
0.483
0,214
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 457-465
application/pdf
dc.publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129116542599168

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