Serum concentrations of acute phase proteins in goats and ewes with naturally acquired Staphylococcus aureus mastitis

• Autor(a) principal: Simplício, K. M.M.G. [UNESP]
• Data de Publicação: 2017
• Outros Autores: Rocha, T. G. [UNESP], Sanchez, D. C.C. [UNESP], Cotrim, F. S. [UNESP], Silva, P. C. [UNESP], Fagliari, J. J. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/1678-4162-8722; http://hdl.handle.net/11449/178876
• topic: Ceruloplasmin; Fibrinogen; Haptoglobin; α1-acid glycoprotein

Serum protein concentrations, including acute phase proteins (APPs), of goats and ewes with naturally acquired Sthaphylococcus aureus mastitis were determined by means of SDS-PAGE electrophoresis to evaluate the relevance of these APPs as biomarkers of the disease in these species. Fifteen healthy goats and 5 goats with naturally acquired staphylococci mastitis, as well as fifteen healthy ewes and 5 ewes with staphylococci mastitis were submitted to daily blood sampling during 7 days. In goats, an increase of 570%, 125%, 621%, and 279% in serum concentrations of ceruloplasmin, fibrinogen, haptoglobin and a1- acid glycoprotein, respectively, was observed. In sheep the increase in serum concentrations of ceruloplasmin, fibrinogen, haptoglobin and α1-acid glycoprotein was of 337%, 90%, 461%, and 225%, respectively. Our results indicate that these APPs have considerable potencial as early and sensible biomarkers of mastitis caused by S. aureus in goats and sheep.