Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/106377 |
Resumo: | The aim of the present study was to evaluate the effect of maternal mild hyperglycemia on maternal behavior, as well as on offspring development, behavior, reproductive function, and development of glucose intolerance in adulthood. At birth, litters were assigned either to Control (subcutaneous(sc)- citrate buffer) or STZ group (streptozotocin(STZ)-100mg/kg-sc.). On PND 90 rats were mated. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed during pregnancy. Pregnancy duration, litter size and sex ratio were assessed. Newborns were classified according to birth weight as small (SPA), adequate (APA), or large for pregnancy age (LPA). Maternal behavior was analyzed on PND 5 and 10. Offspring physical and sexual development was evaluated. Offspring body weight, length, and anogenital distance was measured and general activity was assessed on open field. Sexual behavior studies were conducted on both male and female offspring. Levels of reproductive hormones and estrous cycle duration were evaluated in female offspring. Female offspring were mated and GTT and ITT performed during pregnancy. STZ neonatal administration caused mild hyperglcyemia during pregnancy and changed some aspects of maternal care. The hyperglycemic intrauterine millieu impaired physical development and increased imobility on the open field in the offspring although the latter effect appeared at different ages for males (adulthood) and females (infancy). However, offspring sexual behavior was not impaired and, during pregnancy, STZ female offspring did not become glucose intolerant. Therefore, it can be concluded that mild hyperglycemia during pregnancy caused changes in maternal behavior, as well as offspring development and general activity, but failed to induce glucose... (Complete abstract click electronic access below) |
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Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentesDiabetes na gravidez - Estudos experimentaisHyperglycemiaMaternal careThe aim of the present study was to evaluate the effect of maternal mild hyperglycemia on maternal behavior, as well as on offspring development, behavior, reproductive function, and development of glucose intolerance in adulthood. At birth, litters were assigned either to Control (subcutaneous(sc)- citrate buffer) or STZ group (streptozotocin(STZ)-100mg/kg-sc.). On PND 90 rats were mated. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed during pregnancy. Pregnancy duration, litter size and sex ratio were assessed. Newborns were classified according to birth weight as small (SPA), adequate (APA), or large for pregnancy age (LPA). Maternal behavior was analyzed on PND 5 and 10. Offspring physical and sexual development was evaluated. Offspring body weight, length, and anogenital distance was measured and general activity was assessed on open field. Sexual behavior studies were conducted on both male and female offspring. Levels of reproductive hormones and estrous cycle duration were evaluated in female offspring. Female offspring were mated and GTT and ITT performed during pregnancy. STZ neonatal administration caused mild hyperglcyemia during pregnancy and changed some aspects of maternal care. The hyperglycemic intrauterine millieu impaired physical development and increased imobility on the open field in the offspring although the latter effect appeared at different ages for males (adulthood) and females (infancy). However, offspring sexual behavior was not impaired and, during pregnancy, STZ female offspring did not become glucose intolerant. Therefore, it can be concluded that mild hyperglycemia during pregnancy caused changes in maternal behavior, as well as offspring development and general activity, but failed to induce glucose... (Complete abstract click electronic access below)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista (Unesp)Damasceno, Débora Cristina [UNESP]Universidade Estadual Paulista (Unesp)Kiss, Ana Carolina Inhasz [UNESP]2014-06-11T19:35:39Z2014-06-11T19:35:39Z2011-03-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis104 f.application/pdfKISS, Ana Carolina Inhasz. Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes. 2011. 104 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2011.http://hdl.handle.net/11449/106377000638214kiss_aci_dr_botfm.pdf33004064077P2Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-09-03T18:42:19Zoai:repositorio.unesp.br:11449/106377Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T18:42:19Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
title |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
spellingShingle |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes Kiss, Ana Carolina Inhasz [UNESP] Diabetes na gravidez - Estudos experimentais Hyperglycemia Maternal care |
title_short |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
title_full |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
title_fullStr |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
title_full_unstemmed |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
title_sort |
Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes |
author |
Kiss, Ana Carolina Inhasz [UNESP] |
author_facet |
Kiss, Ana Carolina Inhasz [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Damasceno, Débora Cristina [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Kiss, Ana Carolina Inhasz [UNESP] |
dc.subject.por.fl_str_mv |
Diabetes na gravidez - Estudos experimentais Hyperglycemia Maternal care |
topic |
Diabetes na gravidez - Estudos experimentais Hyperglycemia Maternal care |
description |
The aim of the present study was to evaluate the effect of maternal mild hyperglycemia on maternal behavior, as well as on offspring development, behavior, reproductive function, and development of glucose intolerance in adulthood. At birth, litters were assigned either to Control (subcutaneous(sc)- citrate buffer) or STZ group (streptozotocin(STZ)-100mg/kg-sc.). On PND 90 rats were mated. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed during pregnancy. Pregnancy duration, litter size and sex ratio were assessed. Newborns were classified according to birth weight as small (SPA), adequate (APA), or large for pregnancy age (LPA). Maternal behavior was analyzed on PND 5 and 10. Offspring physical and sexual development was evaluated. Offspring body weight, length, and anogenital distance was measured and general activity was assessed on open field. Sexual behavior studies were conducted on both male and female offspring. Levels of reproductive hormones and estrous cycle duration were evaluated in female offspring. Female offspring were mated and GTT and ITT performed during pregnancy. STZ neonatal administration caused mild hyperglcyemia during pregnancy and changed some aspects of maternal care. The hyperglycemic intrauterine millieu impaired physical development and increased imobility on the open field in the offspring although the latter effect appeared at different ages for males (adulthood) and females (infancy). However, offspring sexual behavior was not impaired and, during pregnancy, STZ female offspring did not become glucose intolerant. Therefore, it can be concluded that mild hyperglycemia during pregnancy caused changes in maternal behavior, as well as offspring development and general activity, but failed to induce glucose... (Complete abstract click electronic access below) |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-03-31 2014-06-11T19:35:39Z 2014-06-11T19:35:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
KISS, Ana Carolina Inhasz. Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes. 2011. 104 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2011. http://hdl.handle.net/11449/106377 000638214 kiss_aci_dr_botfm.pdf 33004064077P2 |
identifier_str_mv |
KISS, Ana Carolina Inhasz. Hiperglicemia materna: efeitos no cuidado materno e no desenvolvimento e comportamento dos descendentes. 2011. 104 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2011. 000638214 kiss_aci_dr_botfm.pdf 33004064077P2 |
url |
http://hdl.handle.net/11449/106377 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
104 f. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021411775840256 |