Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fphar.2018.00168 http://hdl.handle.net/11449/163917 |
Resumo: | Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypertensive therapy. Pharmacogenomics may help to guide the personalized treatment for non-responsive hypertensive patients. There is evidence for the association of genetic variants with variable response to the most commonly used antihypertensive drugs. However, further replication is needed to confirm these associations in different populations. The failure to replicate findings from single-locus association studies has prompted the search for novel statistical methods for data analysis, which are required to detect the complex effects from multiple genes to drug response phenotypes. Notably, genegene interaction analyses have been applied to pharmacogenetic studies, including antihypertensive drug response. In this perspective article, we present advances of considering the interactions among genetic polymorphisms of different candidate genes within pathways relevant to antihypertensive drug response, and we highlight recent findings related to gene-gene interactions on pharmacogenetics of hypertension and preeclampsia. Finally, we discuss the future directions that are needed to unravel additional genes and variants involved in the responsiveness to antihypertensive drugs. |
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Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactionsantihypertensive therapygene-gene interactionsepistasishypertensionpathwayspharmacogenomicspreeclampsiaHypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypertensive therapy. Pharmacogenomics may help to guide the personalized treatment for non-responsive hypertensive patients. There is evidence for the association of genetic variants with variable response to the most commonly used antihypertensive drugs. However, further replication is needed to confirm these associations in different populations. The failure to replicate findings from single-locus association studies has prompted the search for novel statistical methods for data analysis, which are required to detect the complex effects from multiple genes to drug response phenotypes. Notably, genegene interaction analyses have been applied to pharmacogenetic studies, including antihypertensive drug response. In this perspective article, we present advances of considering the interactions among genetic polymorphisms of different candidate genes within pathways relevant to antihypertensive drug response, and we highlight recent findings related to gene-gene interactions on pharmacogenetics of hypertension and preeclampsia. Finally, we discuss the future directions that are needed to unravel additional genes and variants involved in the responsiveness to antihypertensive drugs.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Gen Biol, Belo Horizonte, MG, BrazilUniv Fed Minas Gerais, Inst Biol Sci, UFMG Grad Program Genet, Belo Horizonte, MG, BrazilUniv Estadual Paulista, Inst Biosci Botucatu, Dept Pharmacol, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Biosci Botucatu, Dept Pharmacol, Botucatu, SP, BrazilCNPq: 2014-5/305587FAPESP: 2015/20461-8CNPq: 400295/2014-8Frontiers Media SaUniversidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (Unesp)Luizon, Marcelo R.Pereira, Daniela A.Sandrim, Valeria C. [UNESP]2018-11-26T17:48:24Z2018-11-26T17:48:24Z2018-02-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.3389/fphar.2018.00168Frontiers In Pharmacology. Lausanne: Frontiers Media Sa, v. 9, 6 p., 2018.1663-9812http://hdl.handle.net/11449/16391710.3389/fphar.2018.00168WOS:000426297100001WOS000426297100001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers In Pharmacology1,587info:eu-repo/semantics/openAccess2023-10-03T06:05:02Zoai:repositorio.unesp.br:11449/163917Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:54:22.241803Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
title |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
spellingShingle |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions Luizon, Marcelo R. antihypertensive therapy gene-gene interactions epistasis hypertension pathways pharmacogenomics preeclampsia |
title_short |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
title_full |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
title_fullStr |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
title_full_unstemmed |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
title_sort |
Pharmacogenomics of Hypertension and Preeclampsia: Focus on Gene-Gene Interactions |
author |
Luizon, Marcelo R. |
author_facet |
Luizon, Marcelo R. Pereira, Daniela A. Sandrim, Valeria C. [UNESP] |
author_role |
author |
author2 |
Pereira, Daniela A. Sandrim, Valeria C. [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Minas Gerais (UFMG) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Luizon, Marcelo R. Pereira, Daniela A. Sandrim, Valeria C. [UNESP] |
dc.subject.por.fl_str_mv |
antihypertensive therapy gene-gene interactions epistasis hypertension pathways pharmacogenomics preeclampsia |
topic |
antihypertensive therapy gene-gene interactions epistasis hypertension pathways pharmacogenomics preeclampsia |
description |
Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypertensive therapy. Pharmacogenomics may help to guide the personalized treatment for non-responsive hypertensive patients. There is evidence for the association of genetic variants with variable response to the most commonly used antihypertensive drugs. However, further replication is needed to confirm these associations in different populations. The failure to replicate findings from single-locus association studies has prompted the search for novel statistical methods for data analysis, which are required to detect the complex effects from multiple genes to drug response phenotypes. Notably, genegene interaction analyses have been applied to pharmacogenetic studies, including antihypertensive drug response. In this perspective article, we present advances of considering the interactions among genetic polymorphisms of different candidate genes within pathways relevant to antihypertensive drug response, and we highlight recent findings related to gene-gene interactions on pharmacogenetics of hypertension and preeclampsia. Finally, we discuss the future directions that are needed to unravel additional genes and variants involved in the responsiveness to antihypertensive drugs. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:48:24Z 2018-11-26T17:48:24Z 2018-02-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fphar.2018.00168 Frontiers In Pharmacology. Lausanne: Frontiers Media Sa, v. 9, 6 p., 2018. 1663-9812 http://hdl.handle.net/11449/163917 10.3389/fphar.2018.00168 WOS:000426297100001 WOS000426297100001.pdf |
url |
http://dx.doi.org/10.3389/fphar.2018.00168 http://hdl.handle.net/11449/163917 |
identifier_str_mv |
Frontiers In Pharmacology. Lausanne: Frontiers Media Sa, v. 9, 6 p., 2018. 1663-9812 10.3389/fphar.2018.00168 WOS:000426297100001 WOS000426297100001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers In Pharmacology 1,587 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media Sa |
publisher.none.fl_str_mv |
Frontiers Media Sa |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128289067237376 |