Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10787-022-01128-2 http://hdl.handle.net/11449/246572 |
Resumo: | Nutritional interventions have been shown to be an interesting approach for the treatment of chronic diseases, including inflammatory bowel disease (IBD). Persea americana Mill. (avocado), is a potential food to be used for the prevention or treatment of intestinal inflammation, due to its nutritional value and pharmacological effects. In this study we evaluated if the dietary intervention with avocado fruit pulp could as an intestinal anti-inflammatory diet using a trinitrobenzenesulfonic acid (TNBS) model of intestinal inflammation in rats. For this purpose, 5, 10 or 20% of avocado fruit pulp was incorporated in the diet of rats, for 21 days before and 7 days after TNBS-induced intestinal inflammation. Dietary intervention with avocado fruit pulp (20%) decreased the extension of colonic lesions (1.38 ± 0.99 vs. 2.67 ± 0.76 cm), weight/length colon ratio (151.03 ± 31.45 vs. 197.39 ± 49.48 cm), inhibited myeloperoxidase activity (891.2 ± 243.2 vs 1603 ± 158.2 U/g), reduced tumor necrosis factor-α (53.94 ± 6.45 vs. 114.9 ± 6.21 pg/mg), interleukin-1β (583.6 ± 106.2 vs. 1259 ± 81.68 pg/mg) and interferon gamma (27.95 ± 2.97 vs. 47.79 ± 3.51 pg/mg) levels and prevented colonic glutathione depletion (2585 ± 77.2 vs 1778 ± 167.2 nmol/g). The consumption of enriched diet with 20% avocado pulp by 28 days did not promote any alterations in the biochemical or behavioral parameters evaluated. Avocado showed intestinal anti-inflammatory activity, modulating immune response, and acting as antioxidant. The dietary intervention with avocado was safe, suggesting its potential as a complementary treatment in intestinal inflammation. |
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Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in ratsAvocado pulp, anti-inflammatory activityDietary interventionInflammatory bowel diseasePersea americana MillNutritional interventions have been shown to be an interesting approach for the treatment of chronic diseases, including inflammatory bowel disease (IBD). Persea americana Mill. (avocado), is a potential food to be used for the prevention or treatment of intestinal inflammation, due to its nutritional value and pharmacological effects. In this study we evaluated if the dietary intervention with avocado fruit pulp could as an intestinal anti-inflammatory diet using a trinitrobenzenesulfonic acid (TNBS) model of intestinal inflammation in rats. For this purpose, 5, 10 or 20% of avocado fruit pulp was incorporated in the diet of rats, for 21 days before and 7 days after TNBS-induced intestinal inflammation. Dietary intervention with avocado fruit pulp (20%) decreased the extension of colonic lesions (1.38 ± 0.99 vs. 2.67 ± 0.76 cm), weight/length colon ratio (151.03 ± 31.45 vs. 197.39 ± 49.48 cm), inhibited myeloperoxidase activity (891.2 ± 243.2 vs 1603 ± 158.2 U/g), reduced tumor necrosis factor-α (53.94 ± 6.45 vs. 114.9 ± 6.21 pg/mg), interleukin-1β (583.6 ± 106.2 vs. 1259 ± 81.68 pg/mg) and interferon gamma (27.95 ± 2.97 vs. 47.79 ± 3.51 pg/mg) levels and prevented colonic glutathione depletion (2585 ± 77.2 vs 1778 ± 167.2 nmol/g). The consumption of enriched diet with 20% avocado pulp by 28 days did not promote any alterations in the biochemical or behavioral parameters evaluated. Avocado showed intestinal anti-inflammatory activity, modulating immune response, and acting as antioxidant. The dietary intervention with avocado was safe, suggesting its potential as a complementary treatment in intestinal inflammation.Laboratory of Phytomedicines Pharmacology and Biotechnology Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University UNESP, SPDepartment of Food Science and Nutrition School of Food Engineering University of Campinas–UNICAMP, SPFats and Oils Laboratory School of Food Engineering University of Campinas–UNICAMP, SPLaboratory of Phytomedicines Pharmacology and Biotechnology Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University UNESP, SPUniversidade Estadual Paulista (UNESP)Universidade Estadual de Campinas (UNICAMP)de Oliveira, Ellen Cristina Souza [UNESP]Dalmau, Lesvi Moya [UNESP]de Almeida Costa, Celso Acácio Rodrigues [UNESP]de Almeida Junior, Luiz Domingues [UNESP]Ballard, Cíntia ReisMaróstica Junior, Mário RobertoStahl, Marcella AparecidaGrimaldi, RenatoWitaicenis, Aline [UNESP]Di Stasi, Luiz Claudio [UNESP]2023-07-29T12:44:37Z2023-07-29T12:44:37Z2023-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article485-498http://dx.doi.org/10.1007/s10787-022-01128-2Inflammopharmacology, v. 31, n. 1, p. 485-498, 2023.1568-56080925-4692http://hdl.handle.net/11449/24657210.1007/s10787-022-01128-22-s2.0-85145292220Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInflammopharmacologyinfo:eu-repo/semantics/openAccess2023-07-29T12:44:37Zoai:repositorio.unesp.br:11449/246572Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T12:44:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
title |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
spellingShingle |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats de Oliveira, Ellen Cristina Souza [UNESP] Avocado pulp, anti-inflammatory activity Dietary intervention Inflammatory bowel disease Persea americana Mill |
title_short |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
title_full |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
title_fullStr |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
title_full_unstemmed |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
title_sort |
Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats |
author |
de Oliveira, Ellen Cristina Souza [UNESP] |
author_facet |
de Oliveira, Ellen Cristina Souza [UNESP] Dalmau, Lesvi Moya [UNESP] de Almeida Costa, Celso Acácio Rodrigues [UNESP] de Almeida Junior, Luiz Domingues [UNESP] Ballard, Cíntia Reis Maróstica Junior, Mário Roberto Stahl, Marcella Aparecida Grimaldi, Renato Witaicenis, Aline [UNESP] Di Stasi, Luiz Claudio [UNESP] |
author_role |
author |
author2 |
Dalmau, Lesvi Moya [UNESP] de Almeida Costa, Celso Acácio Rodrigues [UNESP] de Almeida Junior, Luiz Domingues [UNESP] Ballard, Cíntia Reis Maróstica Junior, Mário Roberto Stahl, Marcella Aparecida Grimaldi, Renato Witaicenis, Aline [UNESP] Di Stasi, Luiz Claudio [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
de Oliveira, Ellen Cristina Souza [UNESP] Dalmau, Lesvi Moya [UNESP] de Almeida Costa, Celso Acácio Rodrigues [UNESP] de Almeida Junior, Luiz Domingues [UNESP] Ballard, Cíntia Reis Maróstica Junior, Mário Roberto Stahl, Marcella Aparecida Grimaldi, Renato Witaicenis, Aline [UNESP] Di Stasi, Luiz Claudio [UNESP] |
dc.subject.por.fl_str_mv |
Avocado pulp, anti-inflammatory activity Dietary intervention Inflammatory bowel disease Persea americana Mill |
topic |
Avocado pulp, anti-inflammatory activity Dietary intervention Inflammatory bowel disease Persea americana Mill |
description |
Nutritional interventions have been shown to be an interesting approach for the treatment of chronic diseases, including inflammatory bowel disease (IBD). Persea americana Mill. (avocado), is a potential food to be used for the prevention or treatment of intestinal inflammation, due to its nutritional value and pharmacological effects. In this study we evaluated if the dietary intervention with avocado fruit pulp could as an intestinal anti-inflammatory diet using a trinitrobenzenesulfonic acid (TNBS) model of intestinal inflammation in rats. For this purpose, 5, 10 or 20% of avocado fruit pulp was incorporated in the diet of rats, for 21 days before and 7 days after TNBS-induced intestinal inflammation. Dietary intervention with avocado fruit pulp (20%) decreased the extension of colonic lesions (1.38 ± 0.99 vs. 2.67 ± 0.76 cm), weight/length colon ratio (151.03 ± 31.45 vs. 197.39 ± 49.48 cm), inhibited myeloperoxidase activity (891.2 ± 243.2 vs 1603 ± 158.2 U/g), reduced tumor necrosis factor-α (53.94 ± 6.45 vs. 114.9 ± 6.21 pg/mg), interleukin-1β (583.6 ± 106.2 vs. 1259 ± 81.68 pg/mg) and interferon gamma (27.95 ± 2.97 vs. 47.79 ± 3.51 pg/mg) levels and prevented colonic glutathione depletion (2585 ± 77.2 vs 1778 ± 167.2 nmol/g). The consumption of enriched diet with 20% avocado pulp by 28 days did not promote any alterations in the biochemical or behavioral parameters evaluated. Avocado showed intestinal anti-inflammatory activity, modulating immune response, and acting as antioxidant. The dietary intervention with avocado was safe, suggesting its potential as a complementary treatment in intestinal inflammation. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T12:44:37Z 2023-07-29T12:44:37Z 2023-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10787-022-01128-2 Inflammopharmacology, v. 31, n. 1, p. 485-498, 2023. 1568-5608 0925-4692 http://hdl.handle.net/11449/246572 10.1007/s10787-022-01128-2 2-s2.0-85145292220 |
url |
http://dx.doi.org/10.1007/s10787-022-01128-2 http://hdl.handle.net/11449/246572 |
identifier_str_mv |
Inflammopharmacology, v. 31, n. 1, p. 485-498, 2023. 1568-5608 0925-4692 10.1007/s10787-022-01128-2 2-s2.0-85145292220 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Inflammopharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
485-498 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965644923338752 |