The Role of MicroRNAs in the Osseointegration Process
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.11607/jomi.6581 http://hdl.handle.net/11449/196476 |
Resumo: | Regulation of cellular function is key to bone formation at endosseous implant surfaces. Osseointegration was discovered prior to the discovery of genetic regulation of osteoinduction or characterization of mesenchymal stem cells. Understanding osseointegration in cellular and molecular terms has benefited from genome-wide characterization of this healing process at endosseous implants in vivo. These in vivo studies also demonstrate a role for osteoprogenitor cells and cells involved in immune regulation and osteoclastogenesis. The identification of noncoding RNAs, including microRNAs, as key factors controlling cell function has highlighted the role of microRNAs in cell differentiation control. This review summarizes emerging in vitro and in vivo investigations emphasizing the role of microRNAs in the osseointegration process. Many microRNAs influence key osteoinductive pathways controlling Osterix, runt-related transcription factor 2 (RUNX2), and bone morphogenetic protein (BMP)/SMAD function. Others influence the monocyte/macrophage lineage. While significant progress has been made in elucidating the mechanisms associated with the regulation of surface modulation of osteoblast differentiation by microRNAs, knowledge gaps are evident in the identification and characterization of microRNAs linked to osseointegration. Given existing knowledge regarding the varied expression of microRNAs and their role in inflammation, it is important to understand how microRNA expression may influence the process of bone accrual at implant surfaces during osseointegration. |
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The Role of MicroRNAs in the Osseointegration Processbone remodelingdental implantsimplant surfacesmicroRNAsosseointegrationRegulation of cellular function is key to bone formation at endosseous implant surfaces. Osseointegration was discovered prior to the discovery of genetic regulation of osteoinduction or characterization of mesenchymal stem cells. Understanding osseointegration in cellular and molecular terms has benefited from genome-wide characterization of this healing process at endosseous implants in vivo. These in vivo studies also demonstrate a role for osteoprogenitor cells and cells involved in immune regulation and osteoclastogenesis. The identification of noncoding RNAs, including microRNAs, as key factors controlling cell function has highlighted the role of microRNAs in cell differentiation control. This review summarizes emerging in vitro and in vivo investigations emphasizing the role of microRNAs in the osseointegration process. Many microRNAs influence key osteoinductive pathways controlling Osterix, runt-related transcription factor 2 (RUNX2), and bone morphogenetic protein (BMP)/SMAD function. Others influence the monocyte/macrophage lineage. While significant progress has been made in elucidating the mechanisms associated with the regulation of surface modulation of osteoblast differentiation by microRNAs, knowledge gaps are evident in the identification and characterization of microRNAs linked to osseointegration. Given existing knowledge regarding the varied expression of microRNAs and their role in inflammation, it is important to understand how microRNA expression may influence the process of bone accrual at implant surfaces during osseointegration.Academy of Osseointegration/Osseointegration FoundationIADR - Implant Innovation AwardUniv Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USASao Paulo State Univ, Dept Oral Surg & Integrated Clin, Fac Dent, Aracatuba, BrazilUniv Fed Minas Gerais, Fac Dent, Belo Horizonte, MG, BrazilUniv Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USAUniv Illinois, Coll Dent, Chicago, IL USASao Paulo State Univ, Dept Oral Surg & Integrated Clin, Fac Dent, Aracatuba, BrazilQuintessence Publishing Co IncUniv MichiganUniversidade Estadual Paulista (Unesp)Universidade Federal de Minas Gerais (UFMG)Univ Calif Los AngelesUniv IllinoisSartori, Elisa Mattias [UNESP]das Neves, Andre MartinsMagro-Filho, Osvaldo [UNESP]Silveira Mendonca, Daniela BaccelliKrebsbach, Paul H.Cooper, Lyndon F.Mendonca, Gustavo [UNESP]2020-12-10T19:46:11Z2020-12-10T19:46:11Z2019-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article397-U357http://dx.doi.org/10.11607/jomi.6581International Journal Of Oral & Maxillofacial Implants. Hanover Park: Quintessence Publishing Co Inc, v. 34, n. 2, p. 397-U357, 2019.0882-2786http://hdl.handle.net/11449/19647610.11607/jomi.6581WOS:000506575300014Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal Of Oral & Maxillofacial Implantsinfo:eu-repo/semantics/openAccess2021-10-23T07:00:30Zoai:repositorio.unesp.br:11449/196476Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:14:14.694900Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Role of MicroRNAs in the Osseointegration Process |
title |
The Role of MicroRNAs in the Osseointegration Process |
spellingShingle |
The Role of MicroRNAs in the Osseointegration Process Sartori, Elisa Mattias [UNESP] bone remodeling dental implants implant surfaces microRNAs osseointegration |
title_short |
The Role of MicroRNAs in the Osseointegration Process |
title_full |
The Role of MicroRNAs in the Osseointegration Process |
title_fullStr |
The Role of MicroRNAs in the Osseointegration Process |
title_full_unstemmed |
The Role of MicroRNAs in the Osseointegration Process |
title_sort |
The Role of MicroRNAs in the Osseointegration Process |
author |
Sartori, Elisa Mattias [UNESP] |
author_facet |
Sartori, Elisa Mattias [UNESP] das Neves, Andre Martins Magro-Filho, Osvaldo [UNESP] Silveira Mendonca, Daniela Baccelli Krebsbach, Paul H. Cooper, Lyndon F. Mendonca, Gustavo [UNESP] |
author_role |
author |
author2 |
das Neves, Andre Martins Magro-Filho, Osvaldo [UNESP] Silveira Mendonca, Daniela Baccelli Krebsbach, Paul H. Cooper, Lyndon F. Mendonca, Gustavo [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Michigan Universidade Estadual Paulista (Unesp) Universidade Federal de Minas Gerais (UFMG) Univ Calif Los Angeles Univ Illinois |
dc.contributor.author.fl_str_mv |
Sartori, Elisa Mattias [UNESP] das Neves, Andre Martins Magro-Filho, Osvaldo [UNESP] Silveira Mendonca, Daniela Baccelli Krebsbach, Paul H. Cooper, Lyndon F. Mendonca, Gustavo [UNESP] |
dc.subject.por.fl_str_mv |
bone remodeling dental implants implant surfaces microRNAs osseointegration |
topic |
bone remodeling dental implants implant surfaces microRNAs osseointegration |
description |
Regulation of cellular function is key to bone formation at endosseous implant surfaces. Osseointegration was discovered prior to the discovery of genetic regulation of osteoinduction or characterization of mesenchymal stem cells. Understanding osseointegration in cellular and molecular terms has benefited from genome-wide characterization of this healing process at endosseous implants in vivo. These in vivo studies also demonstrate a role for osteoprogenitor cells and cells involved in immune regulation and osteoclastogenesis. The identification of noncoding RNAs, including microRNAs, as key factors controlling cell function has highlighted the role of microRNAs in cell differentiation control. This review summarizes emerging in vitro and in vivo investigations emphasizing the role of microRNAs in the osseointegration process. Many microRNAs influence key osteoinductive pathways controlling Osterix, runt-related transcription factor 2 (RUNX2), and bone morphogenetic protein (BMP)/SMAD function. Others influence the monocyte/macrophage lineage. While significant progress has been made in elucidating the mechanisms associated with the regulation of surface modulation of osteoblast differentiation by microRNAs, knowledge gaps are evident in the identification and characterization of microRNAs linked to osseointegration. Given existing knowledge regarding the varied expression of microRNAs and their role in inflammation, it is important to understand how microRNA expression may influence the process of bone accrual at implant surfaces during osseointegration. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-01 2020-12-10T19:46:11Z 2020-12-10T19:46:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.11607/jomi.6581 International Journal Of Oral & Maxillofacial Implants. Hanover Park: Quintessence Publishing Co Inc, v. 34, n. 2, p. 397-U357, 2019. 0882-2786 http://hdl.handle.net/11449/196476 10.11607/jomi.6581 WOS:000506575300014 |
url |
http://dx.doi.org/10.11607/jomi.6581 http://hdl.handle.net/11449/196476 |
identifier_str_mv |
International Journal Of Oral & Maxillofacial Implants. Hanover Park: Quintessence Publishing Co Inc, v. 34, n. 2, p. 397-U357, 2019. 0882-2786 10.11607/jomi.6581 WOS:000506575300014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal Of Oral & Maxillofacial Implants |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
397-U357 |
dc.publisher.none.fl_str_mv |
Quintessence Publishing Co Inc |
publisher.none.fl_str_mv |
Quintessence Publishing Co Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129501109944320 |