The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2016/2909576 http://hdl.handle.net/11449/173928 |
Resumo: | The development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6-12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA. |
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Repositório Institucional da UNESP |
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The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individualsThe development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6-12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA.Department of Tropical Diseases Botucatu Medical School (FMB) Universidade Estadual Paulista (UNESP)Department of Pathology FMB/UNESPHemocenter FMB/UNESPDepartment of Biomedical and Clinical Sciences University of MilanDepartment of Tropical Diseases Botucatu Medical School (FMB) Universidade Estadual Paulista (UNESP)Department of Pathology FMB/UNESPHemocenter FMB/UNESPUniversidade Estadual Paulista (Unesp)University of MilanTasca, Karen Ingrid [UNESP]Caleffi, Juliana Trindade [UNESP]Correa, Camila Renata [UNESP]Gatto, Mariana [UNESP]Camargo, Caio Cavassan De [UNESP]Mendes, Monica Bannwart [UNESP]Golim, Marjorie De Assis [UNESP]Biasin, MaraDe Souza, Lenice Do Rosário [UNESP]2018-12-11T17:08:23Z2018-12-11T17:08:23Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2016/2909576Mediators of Inflammation, v. 2016.1466-18610962-9351http://hdl.handle.net/11449/17392810.1155/2016/29095762-s2.0-850061542172-s2.0-85006154217.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators of Inflammation1,3701,370info:eu-repo/semantics/openAccess2023-11-14T06:14:26Zoai:repositorio.unesp.br:11449/173928Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-14T06:14:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
title |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
spellingShingle |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals Tasca, Karen Ingrid [UNESP] |
title_short |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
title_full |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
title_fullStr |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
title_full_unstemmed |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
title_sort |
The initial months of antiretroviral therapy and its influence on AGEs, HMGB1, and sRAGE levels in asymptomatic HIV-infected individuals |
author |
Tasca, Karen Ingrid [UNESP] |
author_facet |
Tasca, Karen Ingrid [UNESP] Caleffi, Juliana Trindade [UNESP] Correa, Camila Renata [UNESP] Gatto, Mariana [UNESP] Camargo, Caio Cavassan De [UNESP] Mendes, Monica Bannwart [UNESP] Golim, Marjorie De Assis [UNESP] Biasin, Mara De Souza, Lenice Do Rosário [UNESP] |
author_role |
author |
author2 |
Caleffi, Juliana Trindade [UNESP] Correa, Camila Renata [UNESP] Gatto, Mariana [UNESP] Camargo, Caio Cavassan De [UNESP] Mendes, Monica Bannwart [UNESP] Golim, Marjorie De Assis [UNESP] Biasin, Mara De Souza, Lenice Do Rosário [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Milan |
dc.contributor.author.fl_str_mv |
Tasca, Karen Ingrid [UNESP] Caleffi, Juliana Trindade [UNESP] Correa, Camila Renata [UNESP] Gatto, Mariana [UNESP] Camargo, Caio Cavassan De [UNESP] Mendes, Monica Bannwart [UNESP] Golim, Marjorie De Assis [UNESP] Biasin, Mara De Souza, Lenice Do Rosário [UNESP] |
description |
The development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6-12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:08:23Z 2018-12-11T17:08:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2016/2909576 Mediators of Inflammation, v. 2016. 1466-1861 0962-9351 http://hdl.handle.net/11449/173928 10.1155/2016/2909576 2-s2.0-85006154217 2-s2.0-85006154217.pdf |
url |
http://dx.doi.org/10.1155/2016/2909576 http://hdl.handle.net/11449/173928 |
identifier_str_mv |
Mediators of Inflammation, v. 2016. 1466-1861 0962-9351 10.1155/2016/2909576 2-s2.0-85006154217 2-s2.0-85006154217.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mediators of Inflammation 1,370 1,370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964933976227840 |