Estudo da segurança de cosméticos: Presente e futuro

• Autor(a) principal: Chiari, Bruna Galdorfini [UNESP]
• Data de Publicação: 2012
• Outros Autores: Magnani, Caroline [UNESP], Salgado, Hérida Regina Nunes [UNESP], Correa, Marcos Antonio [UNESP], Isaac, Vera Lucia Borges [UNESP]
• Tipo de documento: Artigo
• Idioma: eng; por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2161; http://hdl.handle.net/11449/74085
• topic: Alternative methods; Cosmetics; In vitro; Safety; cosmetic; bioassay; Brazil; drug efficacy; drug safety; experimental model; law; nonhuman; review; skin irritation; skin sensitization; systemic disease

Cosmetics have been used since ancient times and, recently, their consumption has increased greatly in many countries, including brazil, which is the third largest consumer market in the world. Thus, concern for the safety and efficacy of these products should be heightened, even though these products are rarely related to adverse reactions that damage the health. Brazilian law requires manufacturers to subject their products to safety testing, to assess the possible reactions that could be caused by them (irritation, sensitization, systemic effects). To this end, in general, animals have been used as the experimental model, but this practice is being increasingly controlled, so that the scientific community is looking for alternative tests that do not require experimental in vivo models. Thus, this review aims to describe the main biological assays used to assess the safety of cosmetics, as well as in vitro assays that can replace them.