Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjp.2015.03.005 http://hdl.handle.net/11449/160768 |
Resumo: | Arrabidaea brachypoda Bureau, Bignoniaceae, known as cipo-una, is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3 beta-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3 beta-estearioxy-olean-12-ene in animals. We observed that 3 beta-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3 beta-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect indifferent tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use. (C) 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved. |
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Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypodaArrabidaea brachypodaInflammationNatural productPainTriterpeneArrabidaea brachypoda Bureau, Bignoniaceae, known as cipo-una, is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3 beta-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3 beta-estearioxy-olean-12-ene in animals. We observed that 3 beta-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3 beta-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect indifferent tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use. (C) 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Inst Quim, Dept Quim Organ, Araraquara, SP, BrazilUniv Fed Alfenas, Inst Ciencias Biomed, Dept Ciencias Fisiol, Alfenas, MG, BrazilSoc Brasileira Fisiol, Programa Multictr Posgrad Ciencias Fisiol, Sao Paulo, SP, BrazilUniv Fed Vicosa, Dept Quim, Vicosa, MG, BrazilUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Araraquara, SP, BrazilSoc Brasileira FarmacognosiaUniversidade Estadual Paulista (Unesp)Univ Fed AlfenasSoc Brasileira FisiolUniversidade Federal de Viçosa (UFV)Rocha, Cludia Q. da [UNESP]Vilela, Fabiana C.Santa-Cecilia, Flavia V.Cavalcante, Gustavo P.Vilegas, Wagner [UNESP]Giusti-Paiva, AlexandreSantos, Marcelo H. dos2018-11-26T16:16:40Z2018-11-26T16:16:40Z2015-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article228-232application/pdfhttp://dx.doi.org/10.1016/j.bjp.2015.03.005Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 25, n. 3, p. 228-232, 2015.0102-695Xhttp://hdl.handle.net/11449/16076810.1016/j.bjp.2015.03.005S0102-695X2015000300228WOS:000360550100006S0102-695X2015000300228.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosyinfo:eu-repo/semantics/openAccess2023-11-14T06:16:37Zoai:repositorio.unesp.br:11449/160768Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:41:27.402315Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
title |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
spellingShingle |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda Rocha, Cludia Q. da [UNESP] Arrabidaea brachypoda Inflammation Natural product Pain Triterpene |
title_short |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
title_full |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
title_fullStr |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
title_full_unstemmed |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
title_sort |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda |
author |
Rocha, Cludia Q. da [UNESP] |
author_facet |
Rocha, Cludia Q. da [UNESP] Vilela, Fabiana C. Santa-Cecilia, Flavia V. Cavalcante, Gustavo P. Vilegas, Wagner [UNESP] Giusti-Paiva, Alexandre Santos, Marcelo H. dos |
author_role |
author |
author2 |
Vilela, Fabiana C. Santa-Cecilia, Flavia V. Cavalcante, Gustavo P. Vilegas, Wagner [UNESP] Giusti-Paiva, Alexandre Santos, Marcelo H. dos |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Fed Alfenas Soc Brasileira Fisiol Universidade Federal de Viçosa (UFV) |
dc.contributor.author.fl_str_mv |
Rocha, Cludia Q. da [UNESP] Vilela, Fabiana C. Santa-Cecilia, Flavia V. Cavalcante, Gustavo P. Vilegas, Wagner [UNESP] Giusti-Paiva, Alexandre Santos, Marcelo H. dos |
dc.subject.por.fl_str_mv |
Arrabidaea brachypoda Inflammation Natural product Pain Triterpene |
topic |
Arrabidaea brachypoda Inflammation Natural product Pain Triterpene |
description |
Arrabidaea brachypoda Bureau, Bignoniaceae, known as cipo-una, is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3 beta-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3 beta-estearioxy-olean-12-ene in animals. We observed that 3 beta-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3 beta-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect indifferent tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use. (C) 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05-01 2018-11-26T16:16:40Z 2018-11-26T16:16:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjp.2015.03.005 Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 25, n. 3, p. 228-232, 2015. 0102-695X http://hdl.handle.net/11449/160768 10.1016/j.bjp.2015.03.005 S0102-695X2015000300228 WOS:000360550100006 S0102-695X2015000300228.pdf |
url |
http://dx.doi.org/10.1016/j.bjp.2015.03.005 http://hdl.handle.net/11449/160768 |
identifier_str_mv |
Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 25, n. 3, p. 228-232, 2015. 0102-695X 10.1016/j.bjp.2015.03.005 S0102-695X2015000300228 WOS:000360550100006 S0102-695X2015000300228.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
228-232 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Farmacognosia |
publisher.none.fl_str_mv |
Soc Brasileira Farmacognosia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128845630406656 |