Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.002 http://hdl.handle.net/11449/173724 |
Resumo: | We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections. |
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Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.AntifungalCaffeic acidCandida albicansSynergismWe tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections.Department of Clinical Analysis Laboratory of Clinical Mycology Faculty of Pharmaceutical Sciences UNESP–Univ Estadual PaulistaDepartment of Biochemistry and Chemical Technology Institute of Chemistry UNESP–Univ Estadual PaulistaDepartment of Physiological Sciences Piracicaba Dental School University of CampinasDepartment of Chemistry and Environmental Sciences Institute of Biosciences Letters and Exact SciencesDepartment of Clinical Analysis Laboratory of Clinical Mycology Faculty of Pharmaceutical Sciences UNESP–Univ Estadual PaulistaDepartment of Biochemistry and Chemical Technology Institute of Chemistry UNESP–Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Letters and Exact SciencesSardi, Janaína de Cássia Orlandi [UNESP]Gullo, Fernanda Patrícia [UNESP]Freires, Irlan AlmeidaPitangui, Nayla de Souza [UNESP]Segalla, Maicon Petrônio [UNESP]Fusco-Almeida, Ana Marisa [UNESP]Rosalen, Pedro LuizRegasini, Luís Octávio [UNESP]Mendes-Giannini, Maria José Soares [UNESP]2018-12-11T17:07:27Z2018-12-11T17:07:27Z2016-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article387-391application/pdfhttp://dx.doi.org/10.1016/j.diagmicrobio.2016.08.002Diagnostic Microbiology and Infectious Disease, v. 86, n. 4, p. 387-391, 2016.1879-00700732-8893http://hdl.handle.net/11449/17372410.1016/j.diagmicrobio.2016.08.0022-s2.0-849942343782-s2.0-84994234378.pdf0992736452764550Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiagnostic Microbiology and Infectious Disease1,157info:eu-repo/semantics/openAccess2024-01-15T06:17:20Zoai:repositorio.unesp.br:11449/173724Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-15T06:17:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| title |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| spellingShingle |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. Sardi, Janaína de Cássia Orlandi [UNESP] Antifungal Caffeic acid Candida albicans Synergism |
| title_short |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| title_full |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| title_fullStr |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| title_full_unstemmed |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| title_sort |
Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. |
| author |
Sardi, Janaína de Cássia Orlandi [UNESP] |
| author_facet |
Sardi, Janaína de Cássia Orlandi [UNESP] Gullo, Fernanda Patrícia [UNESP] Freires, Irlan Almeida Pitangui, Nayla de Souza [UNESP] Segalla, Maicon Petrônio [UNESP] Fusco-Almeida, Ana Marisa [UNESP] Rosalen, Pedro Luiz Regasini, Luís Octávio [UNESP] Mendes-Giannini, Maria José Soares [UNESP] |
| author_role |
author |
| author2 |
Gullo, Fernanda Patrícia [UNESP] Freires, Irlan Almeida Pitangui, Nayla de Souza [UNESP] Segalla, Maicon Petrônio [UNESP] Fusco-Almeida, Ana Marisa [UNESP] Rosalen, Pedro Luiz Regasini, Luís Octávio [UNESP] Mendes-Giannini, Maria José Soares [UNESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) Letters and Exact Sciences |
| dc.contributor.author.fl_str_mv |
Sardi, Janaína de Cássia Orlandi [UNESP] Gullo, Fernanda Patrícia [UNESP] Freires, Irlan Almeida Pitangui, Nayla de Souza [UNESP] Segalla, Maicon Petrônio [UNESP] Fusco-Almeida, Ana Marisa [UNESP] Rosalen, Pedro Luiz Regasini, Luís Octávio [UNESP] Mendes-Giannini, Maria José Soares [UNESP] |
| dc.subject.por.fl_str_mv |
Antifungal Caffeic acid Candida albicans Synergism |
| topic |
Antifungal Caffeic acid Candida albicans Synergism |
| description |
We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-12-01 2018-12-11T17:07:27Z 2018-12-11T17:07:27Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.002 Diagnostic Microbiology and Infectious Disease, v. 86, n. 4, p. 387-391, 2016. 1879-0070 0732-8893 http://hdl.handle.net/11449/173724 10.1016/j.diagmicrobio.2016.08.002 2-s2.0-84994234378 2-s2.0-84994234378.pdf 0992736452764550 |
| url |
http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.002 http://hdl.handle.net/11449/173724 |
| identifier_str_mv |
Diagnostic Microbiology and Infectious Disease, v. 86, n. 4, p. 387-391, 2016. 1879-0070 0732-8893 10.1016/j.diagmicrobio.2016.08.002 2-s2.0-84994234378 2-s2.0-84994234378.pdf 0992736452764550 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Diagnostic Microbiology and Infectious Disease 1,157 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
387-391 application/pdf |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1799965619037143040 |