Uso do beta fosfato tricálcio em levantamento da membrana de seio maxilar: estudo histológico, histomorfométrico e imunoistoquímico em coelhos

• Autor(a) principal: Bermejo, Patrícia Rota [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/123215; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/29-04-2015/000826791.pdf
• topic: Seios maxilares; Materiais biomédicos; Regeneração tecidual guiada; Maxillary sinus

The beta tri calcium phosphate (β-TCP) is a biomaterial with excellent osteoconductive properties, biocompatibility by being chemically and crystallographically similar to the human bone tissue as well as having rapid reabsorption which reduces biological reactions. The β-TCP has been used in bone grafting surgery, especially in the upper regions of the maxilla in order to facilitate the prosthetic rehabilitation with implants. The aim of this study is to evaluate the healing of a biomaterial-based beta tri calcium phosphate, β-TC in sinus lifting of rabbits, using histological, histomorphometric and immunohistochemistry. Twenty Albinus rabbits underwent surgery to the bilateral maxillary sinus lift, where the right maxillary sinus was filled with blood clot and the left by β-TCP. After periods of 3, 7, 15 and 45 days the animals were euthanized and their jaw removed for processing and histological, immunohistochemistry and histometric analysis. There was bone formation for both groups only from the period of 15 days. The Tukey statistical test was applied, and there was statistical difference (p <0.01) between the control group and the β-TCP group. The best index of bone formation was for the β-TCP group in period prescribed 45 days (33,011 ± 0.0294%) compared to the control group (30.502 ± 1.824%). There were also significant differences among groups in relation to the studied periods. Thus, we proved that the βTCP was a competent bone substitute in relation to bone formation and maintenance area, allowed for proper oral rehabilitation clinical defects