Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation

Detalhes bibliográficos
Autor(a) principal: Horr, M. [UNESP]
Data de Publicação: 2019
Outros Autores: Nunes, N. [UNESP], Biteli, E. G. F. [UNESP], Lopes, P. C. F. [UNESP], Gering, A. P. [UNESP], Moro, J. [UNESP], Rocha, F. D. L. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-4162-10472
http://hdl.handle.net/11449/184550
Resumo: It is important to identify the best inspired fraction of oxygen in a variety of situations, including sevoflurane or isoflurane anesthesia, in spontaneously breathing rabbits. For this, 64 rabbits were assigned to eight groups: GI100 (FiO(2) = 1,0 + isoflurane), GS100 (FiO(2) = 1,0 + sevoflurane), GI80 (FiO(2) = 0,8 + isoflurane), GS80 (FiO(2) = 0,8 + sevoflurane), GI60 (FiO(2) = 0,6 + isoflurane), GS60 (FiO(2) = 0,6 + sevoflurane), GI21 (FiO(2) = 0,21 + isoflurane), GS21 (FiO(2) = 0,21 + sevoflurane). The induction was performed with (2.5MAC) of the anesthetic. The vaporizer was setted at 1.5 MAC and FiO(2) as attributed for each group. After the induction, the concentration was changed to 1 MAC. Measurements of parameters were performed 30 minutes after induction (TO), and then at 15 minute intervals (from T15 to T60). The arterial partial pressures of oxygen (PaO2), alveolar oxygen partial pressure (PAO2) and alveolar-arterial oxygen gradient [P(A-a)O-2] were higher with the use of high FiO(2). The GI80 showed higher levels of PaO2 FiO(2) ratio and respiratory index (RI). In conclusion, the FiO(2) of 0.21 is not indicated, because it causes hypoxemia. The isoflurane determines better ventilation when compared to sevoflurane, but isoflurane associated with 80% of oxygen promotes intrapulmonary shunt increase.
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spelling Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilationrabbitinhalatory anesthesiaventilationIt is important to identify the best inspired fraction of oxygen in a variety of situations, including sevoflurane or isoflurane anesthesia, in spontaneously breathing rabbits. For this, 64 rabbits were assigned to eight groups: GI100 (FiO(2) = 1,0 + isoflurane), GS100 (FiO(2) = 1,0 + sevoflurane), GI80 (FiO(2) = 0,8 + isoflurane), GS80 (FiO(2) = 0,8 + sevoflurane), GI60 (FiO(2) = 0,6 + isoflurane), GS60 (FiO(2) = 0,6 + sevoflurane), GI21 (FiO(2) = 0,21 + isoflurane), GS21 (FiO(2) = 0,21 + sevoflurane). The induction was performed with (2.5MAC) of the anesthetic. The vaporizer was setted at 1.5 MAC and FiO(2) as attributed for each group. After the induction, the concentration was changed to 1 MAC. Measurements of parameters were performed 30 minutes after induction (TO), and then at 15 minute intervals (from T15 to T60). The arterial partial pressures of oxygen (PaO2), alveolar oxygen partial pressure (PAO2) and alveolar-arterial oxygen gradient [P(A-a)O-2] were higher with the use of high FiO(2). The GI80 showed higher levels of PaO2 FiO(2) ratio and respiratory index (RI). In conclusion, the FiO(2) of 0.21 is not indicated, because it causes hypoxemia. The isoflurane determines better ventilation when compared to sevoflurane, but isoflurane associated with 80% of oxygen promotes intrapulmonary shunt increase.Univ Estadual Paulista, Jaboticabal, SP, BrazilUniv Estadual Paulista, Jaboticabal, SP, BrazilArquivo Brasileiro Medicina Veterinaria ZootecniaUniversidade Estadual Paulista (Unesp)Horr, M. [UNESP]Nunes, N. [UNESP]Biteli, E. G. F. [UNESP]Lopes, P. C. F. [UNESP]Gering, A. P. [UNESP]Moro, J. [UNESP]Rocha, F. D. L. [UNESP]2019-10-04T12:14:34Z2019-10-04T12:14:34Z2019-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article944-952application/pdfhttp://dx.doi.org/10.1590/1678-4162-10472Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 71, n. 3, p. 944-952, 2019.0102-0935http://hdl.handle.net/11449/18455010.1590/1678-4162-10472S0102-09352019000300944WOS:000473319900029S0102-09352019000300944.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro De Medicina Veterinaria E Zootecniainfo:eu-repo/semantics/openAccess2023-11-06T06:09:56Zoai:repositorio.unesp.br:11449/184550Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:01:36.598374Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
title Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
spellingShingle Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
Horr, M. [UNESP]
rabbit
inhalatory anesthesia
ventilation
title_short Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
title_full Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
title_fullStr Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
title_full_unstemmed Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
title_sort Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
author Horr, M. [UNESP]
author_facet Horr, M. [UNESP]
Nunes, N. [UNESP]
Biteli, E. G. F. [UNESP]
Lopes, P. C. F. [UNESP]
Gering, A. P. [UNESP]
Moro, J. [UNESP]
Rocha, F. D. L. [UNESP]
author_role author
author2 Nunes, N. [UNESP]
Biteli, E. G. F. [UNESP]
Lopes, P. C. F. [UNESP]
Gering, A. P. [UNESP]
Moro, J. [UNESP]
Rocha, F. D. L. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Horr, M. [UNESP]
Nunes, N. [UNESP]
Biteli, E. G. F. [UNESP]
Lopes, P. C. F. [UNESP]
Gering, A. P. [UNESP]
Moro, J. [UNESP]
Rocha, F. D. L. [UNESP]
dc.subject.por.fl_str_mv rabbit
inhalatory anesthesia
ventilation
topic rabbit
inhalatory anesthesia
ventilation
description It is important to identify the best inspired fraction of oxygen in a variety of situations, including sevoflurane or isoflurane anesthesia, in spontaneously breathing rabbits. For this, 64 rabbits were assigned to eight groups: GI100 (FiO(2) = 1,0 + isoflurane), GS100 (FiO(2) = 1,0 + sevoflurane), GI80 (FiO(2) = 0,8 + isoflurane), GS80 (FiO(2) = 0,8 + sevoflurane), GI60 (FiO(2) = 0,6 + isoflurane), GS60 (FiO(2) = 0,6 + sevoflurane), GI21 (FiO(2) = 0,21 + isoflurane), GS21 (FiO(2) = 0,21 + sevoflurane). The induction was performed with (2.5MAC) of the anesthetic. The vaporizer was setted at 1.5 MAC and FiO(2) as attributed for each group. After the induction, the concentration was changed to 1 MAC. Measurements of parameters were performed 30 minutes after induction (TO), and then at 15 minute intervals (from T15 to T60). The arterial partial pressures of oxygen (PaO2), alveolar oxygen partial pressure (PAO2) and alveolar-arterial oxygen gradient [P(A-a)O-2] were higher with the use of high FiO(2). The GI80 showed higher levels of PaO2 FiO(2) ratio and respiratory index (RI). In conclusion, the FiO(2) of 0.21 is not indicated, because it causes hypoxemia. The isoflurane determines better ventilation when compared to sevoflurane, but isoflurane associated with 80% of oxygen promotes intrapulmonary shunt increase.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:14:34Z
2019-10-04T12:14:34Z
2019-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-4162-10472
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 71, n. 3, p. 944-952, 2019.
0102-0935
http://hdl.handle.net/11449/184550
10.1590/1678-4162-10472
S0102-09352019000300944
WOS:000473319900029
S0102-09352019000300944.pdf
url http://dx.doi.org/10.1590/1678-4162-10472
http://hdl.handle.net/11449/184550
identifier_str_mv Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 71, n. 3, p. 944-952, 2019.
0102-0935
10.1590/1678-4162-10472
S0102-09352019000300944
WOS:000473319900029
S0102-09352019000300944.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivo Brasileiro De Medicina Veterinaria E Zootecnia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 944-952
application/pdf
dc.publisher.none.fl_str_mv Arquivo Brasileiro Medicina Veterinaria Zootecnia
publisher.none.fl_str_mv Arquivo Brasileiro Medicina Veterinaria Zootecnia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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