Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/nano11061362 http://hdl.handle.net/11449/207760 |
Resumo: | Ureasil-Poly(ethylene oxide) (ureasil-PEO500) and ureasil-Poly(propylene oxide) (u-PPO400) films, unloaded and loaded with dexamethasone acetate (DMA), have been investigated by car-rying out atomic force microscopy (AFM), ultrasonic force microscopy (UFM), contact-angle, and drug release experiments. In addition, X-ray diffraction, small angle X-ray scattering, and infrared spectroscopy have provided essential information to understand the films’ structural organization. Our results reveal that while in u-PEO500 DMA occupies sites near the ether oxygen and remains absent from the film surface, in u-PPO400 new crystalline phases are formed when DMA is loaded, which show up as ~30–100 nm in diameter rounded clusters aligned along a well-defined direc-tion, presumably related to the one defined by the characteristic polymer ropes distinguished on the surface of the unloaded u-POP film; occasionally, larger needle-shaped DMA crystals are also observed. UFM reveals that in the unloaded u-PPO matrix the polymer ropes are made up of strands, which in turn consist of aligned ~180 nm in diameter stiffer rounded clusters possibly formed by siloxane-node aggregates; the new crystalline phases may grow in-between the strands when the drug is loaded. The results illustrate the potential of AFM-based procedures, in combination with additional physico-chemical techniques, to picture the nanostructural arrangements in polymer matrices intended for drug delivery. |
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Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetateAtomic force microscopyOrganic-inorganic hybrid filmsSol-gelUltrasonic force microscopyUreasil-Poly(ethylene oxide) (ureasil-PEO500) and ureasil-Poly(propylene oxide) (u-PPO400) films, unloaded and loaded with dexamethasone acetate (DMA), have been investigated by car-rying out atomic force microscopy (AFM), ultrasonic force microscopy (UFM), contact-angle, and drug release experiments. In addition, X-ray diffraction, small angle X-ray scattering, and infrared spectroscopy have provided essential information to understand the films’ structural organization. Our results reveal that while in u-PEO500 DMA occupies sites near the ether oxygen and remains absent from the film surface, in u-PPO400 new crystalline phases are formed when DMA is loaded, which show up as ~30–100 nm in diameter rounded clusters aligned along a well-defined direc-tion, presumably related to the one defined by the characteristic polymer ropes distinguished on the surface of the unloaded u-POP film; occasionally, larger needle-shaped DMA crystals are also observed. UFM reveals that in the unloaded u-PPO matrix the polymer ropes are made up of strands, which in turn consist of aligned ~180 nm in diameter stiffer rounded clusters possibly formed by siloxane-node aggregates; the new crystalline phases may grow in-between the strands when the drug is loaded. The results illustrate the potential of AFM-based procedures, in combination with additional physico-chemical techniques, to picture the nanostructural arrangements in polymer matrices intended for drug delivery.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Federación Española de Enfermedades RarasDepartment of Applied Mechanics and Project Engineering University of Castilla-La Mancha, Plaza Manuel Meca 1Laboratory of Development and Characterization of Pharmaceutical Products Department of Pharmacy Center for Biological and Health Sciences State University of Paraíba (UEPB)Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-JaúDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Highway Araraquara-JaúUniversity of Castilla-La ManchaState University of Paraíba (UEPB)Universidade Estadual Paulista (Unesp)Oshiro, Joao AugustoLusuardi, AngeloBeamud, Elena M.Chiavacci, Leila Aparecida [UNESP]Cuberes, M. Teresa2021-06-25T11:00:34Z2021-06-25T11:00:34Z2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/nano11061362Nanomaterials, v. 11, n. 6, 2021.2079-4991http://hdl.handle.net/11449/20776010.3390/nano110613622-s2.0-85106318134Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomaterialsinfo:eu-repo/semantics/openAccess2024-06-24T13:46:33Zoai:repositorio.unesp.br:11449/207760Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:36:34.849200Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
title |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
spellingShingle |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate Oshiro, Joao Augusto Atomic force microscopy Organic-inorganic hybrid films Sol-gel Ultrasonic force microscopy |
title_short |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
title_full |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
title_fullStr |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
title_full_unstemmed |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
title_sort |
Nanostructural arrangements and surface morphology on ureasil-polyether films loaded with dexamethasone acetate |
author |
Oshiro, Joao Augusto |
author_facet |
Oshiro, Joao Augusto Lusuardi, Angelo Beamud, Elena M. Chiavacci, Leila Aparecida [UNESP] Cuberes, M. Teresa |
author_role |
author |
author2 |
Lusuardi, Angelo Beamud, Elena M. Chiavacci, Leila Aparecida [UNESP] Cuberes, M. Teresa |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
University of Castilla-La Mancha State University of Paraíba (UEPB) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Oshiro, Joao Augusto Lusuardi, Angelo Beamud, Elena M. Chiavacci, Leila Aparecida [UNESP] Cuberes, M. Teresa |
dc.subject.por.fl_str_mv |
Atomic force microscopy Organic-inorganic hybrid films Sol-gel Ultrasonic force microscopy |
topic |
Atomic force microscopy Organic-inorganic hybrid films Sol-gel Ultrasonic force microscopy |
description |
Ureasil-Poly(ethylene oxide) (ureasil-PEO500) and ureasil-Poly(propylene oxide) (u-PPO400) films, unloaded and loaded with dexamethasone acetate (DMA), have been investigated by car-rying out atomic force microscopy (AFM), ultrasonic force microscopy (UFM), contact-angle, and drug release experiments. In addition, X-ray diffraction, small angle X-ray scattering, and infrared spectroscopy have provided essential information to understand the films’ structural organization. Our results reveal that while in u-PEO500 DMA occupies sites near the ether oxygen and remains absent from the film surface, in u-PPO400 new crystalline phases are formed when DMA is loaded, which show up as ~30–100 nm in diameter rounded clusters aligned along a well-defined direc-tion, presumably related to the one defined by the characteristic polymer ropes distinguished on the surface of the unloaded u-POP film; occasionally, larger needle-shaped DMA crystals are also observed. UFM reveals that in the unloaded u-PPO matrix the polymer ropes are made up of strands, which in turn consist of aligned ~180 nm in diameter stiffer rounded clusters possibly formed by siloxane-node aggregates; the new crystalline phases may grow in-between the strands when the drug is loaded. The results illustrate the potential of AFM-based procedures, in combination with additional physico-chemical techniques, to picture the nanostructural arrangements in polymer matrices intended for drug delivery. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:00:34Z 2021-06-25T11:00:34Z 2021-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/nano11061362 Nanomaterials, v. 11, n. 6, 2021. 2079-4991 http://hdl.handle.net/11449/207760 10.3390/nano11061362 2-s2.0-85106318134 |
url |
http://dx.doi.org/10.3390/nano11061362 http://hdl.handle.net/11449/207760 |
identifier_str_mv |
Nanomaterials, v. 11, n. 6, 2021. 2079-4991 10.3390/nano11061362 2-s2.0-85106318134 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nanomaterials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129536083099648 |