Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium

Detalhes bibliográficos
Autor(a) principal: Giacomini, V. A.
Data de Publicação: 1986
Outros Autores: Reis, C. C.A. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/0306-3623(86)90142-4
http://hdl.handle.net/11449/219117
Resumo: 1. 1. Norepinephrine (NE) and histamine (His) cause a dose related increase in the rate of the guinea pig isolated right atria. 2. 2. The rate increase induced by both amines has been shown to be mediated by pharmacologically different receptors. 3. 3. His shifted the NE CEC to the right in a non parallel fashion. Cimetidine (10-4 mol/l) abolished this antagonism. 4. 4. Norepinephrine (3 × 10-7 mol/l) shifted to the right the His CEC also in a non parallel fashion. Practolol (10-4 mol/l) abolished this antagonism. 5. 5. Theophylline (10-4 mol/l) reverted both: the antagonistic action of His related to the NE chronotropic effect and the antagonistic action of NE related to the His chronotropic effect. 6. 6. The reversal of the antagonism could be the result of the block of purinergic P1-receptors by theophylline. 7. 7. This block impairs the chronotropic effect of adenilic compounds which can function as a modulater of cardiac rate through a negative feed back mechanism. © 1986.
id UNSP_7ec23c690534a2d1d7d8fc05bb127012
oai_identifier_str oai:repositorio.unesp.br:11449/219117
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium1. 1. Norepinephrine (NE) and histamine (His) cause a dose related increase in the rate of the guinea pig isolated right atria. 2. 2. The rate increase induced by both amines has been shown to be mediated by pharmacologically different receptors. 3. 3. His shifted the NE CEC to the right in a non parallel fashion. Cimetidine (10-4 mol/l) abolished this antagonism. 4. 4. Norepinephrine (3 × 10-7 mol/l) shifted to the right the His CEC also in a non parallel fashion. Practolol (10-4 mol/l) abolished this antagonism. 5. 5. Theophylline (10-4 mol/l) reverted both: the antagonistic action of His related to the NE chronotropic effect and the antagonistic action of NE related to the His chronotropic effect. 6. 6. The reversal of the antagonism could be the result of the block of purinergic P1-receptors by theophylline. 7. 7. This block impairs the chronotropic effect of adenilic compounds which can function as a modulater of cardiac rate through a negative feed back mechanism. © 1986.Department of Pharmacology, Institute of Biomedical Sciences, USP, São Paulo, SPDepartment of Pharmacology, School of Pharmaceutical Sciences, UNESP, Araraquara, SPDepartment of Pharmacology, School of Pharmaceutical Sciences, UNESP, Araraquara, SPUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Giacomini, V. A.Reis, C. C.A. [UNESP]2022-04-28T18:53:53Z2022-04-28T18:53:53Z1986-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article219-225http://dx.doi.org/10.1016/0306-3623(86)90142-4General Pharmacology, v. 17, n. 2, p. 219-225, 1986.0306-3623http://hdl.handle.net/11449/21911710.1016/0306-3623(86)90142-42-s2.0-0022600839Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGeneral Pharmacologyinfo:eu-repo/semantics/openAccess2022-04-28T18:53:53Zoai:repositorio.unesp.br:11449/219117Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:09:06.161204Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
title Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
spellingShingle Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
Giacomini, V. A.
title_short Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
title_full Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
title_fullStr Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
title_full_unstemmed Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
title_sort Antagonistic effect between histamine and norepinephrine on isolated guinea-pig right atrium
author Giacomini, V. A.
author_facet Giacomini, V. A.
Reis, C. C.A. [UNESP]
author_role author
author2 Reis, C. C.A. [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Giacomini, V. A.
Reis, C. C.A. [UNESP]
description 1. 1. Norepinephrine (NE) and histamine (His) cause a dose related increase in the rate of the guinea pig isolated right atria. 2. 2. The rate increase induced by both amines has been shown to be mediated by pharmacologically different receptors. 3. 3. His shifted the NE CEC to the right in a non parallel fashion. Cimetidine (10-4 mol/l) abolished this antagonism. 4. 4. Norepinephrine (3 × 10-7 mol/l) shifted to the right the His CEC also in a non parallel fashion. Practolol (10-4 mol/l) abolished this antagonism. 5. 5. Theophylline (10-4 mol/l) reverted both: the antagonistic action of His related to the NE chronotropic effect and the antagonistic action of NE related to the His chronotropic effect. 6. 6. The reversal of the antagonism could be the result of the block of purinergic P1-receptors by theophylline. 7. 7. This block impairs the chronotropic effect of adenilic compounds which can function as a modulater of cardiac rate through a negative feed back mechanism. © 1986.
publishDate 1986
dc.date.none.fl_str_mv 1986-01-01
2022-04-28T18:53:53Z
2022-04-28T18:53:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/0306-3623(86)90142-4
General Pharmacology, v. 17, n. 2, p. 219-225, 1986.
0306-3623
http://hdl.handle.net/11449/219117
10.1016/0306-3623(86)90142-4
2-s2.0-0022600839
url http://dx.doi.org/10.1016/0306-3623(86)90142-4
http://hdl.handle.net/11449/219117
identifier_str_mv General Pharmacology, v. 17, n. 2, p. 219-225, 1986.
0306-3623
10.1016/0306-3623(86)90142-4
2-s2.0-0022600839
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv General Pharmacology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 219-225
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129397609201664