Seleção genômica para características de carcaça em bovinos da raça Nelore
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/123656 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/08-06-2015/000834736.pdf |
Resumo: | Economic relevant traits as carcass, measured after slaughter, are not included in the animal breeding program of Nelore breed due to the difficult and high cost to measure. With the advent of genomic selection, it is possible to select animals without the need of recording phenotypic performance of its own or from close relatives, and there is also the possibility of investigating genes or chromosome regions affecting the expression of traits using genome-wide association study (GWAS). The aim of this study was to compare different models on the predictive ability of genomic breeding values (GEBVs), and to perform a GWAS for the following traits: hot carcass weight, rib eye area, and backfat thickness, in order to contribute to the incorporation of genomic information into the genetic evaluation of beef cattle in Brazil. Genotypic and phenotypic information of 1,756 Nelore bulls were used in the analysis. Genotypes were generated based on a panel with 777.962 SNPs. The GEBVs were predicted using three models: Bayesian Ridge Regression (BRR), BayesC (BC) e Bayesian Lasso (BL), and two types of response variables: estimated breeding value and adjusted phenotypes for the fixed effects. GWAS was performed using the singlestep approach which combines all available phenotypic, pedigree and genomic information adjusting a polygenic-genomic model. In general, it was verified that heritability and response variable affected the genomic predictions, where the adjusted phenotype was the most appropriate response variable to perform SNPs estimates. It was also observed that the predictive abilities were similar among the methods (BRR, BC and BL). GWAS study detected potential genome regions that may be affecting the phenotypes. These regions can contribute to understand the genetic control of these traits and can be useful to include them into the genetic process for selecting the animals. The results showed that marker assited selection is ... |
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Seleção genômica para características de carcaça em bovinos da raça NeloreBovino de corteNelore (Zebu)Bovino de corte - CarcaçasGenômicaMarcadores genéticosGenetica animalGenomicsEconomic relevant traits as carcass, measured after slaughter, are not included in the animal breeding program of Nelore breed due to the difficult and high cost to measure. With the advent of genomic selection, it is possible to select animals without the need of recording phenotypic performance of its own or from close relatives, and there is also the possibility of investigating genes or chromosome regions affecting the expression of traits using genome-wide association study (GWAS). The aim of this study was to compare different models on the predictive ability of genomic breeding values (GEBVs), and to perform a GWAS for the following traits: hot carcass weight, rib eye area, and backfat thickness, in order to contribute to the incorporation of genomic information into the genetic evaluation of beef cattle in Brazil. Genotypic and phenotypic information of 1,756 Nelore bulls were used in the analysis. Genotypes were generated based on a panel with 777.962 SNPs. The GEBVs were predicted using three models: Bayesian Ridge Regression (BRR), BayesC (BC) e Bayesian Lasso (BL), and two types of response variables: estimated breeding value and adjusted phenotypes for the fixed effects. GWAS was performed using the singlestep approach which combines all available phenotypic, pedigree and genomic information adjusting a polygenic-genomic model. In general, it was verified that heritability and response variable affected the genomic predictions, where the adjusted phenotype was the most appropriate response variable to perform SNPs estimates. It was also observed that the predictive abilities were similar among the methods (BRR, BC and BL). GWAS study detected potential genome regions that may be affecting the phenotypes. These regions can contribute to understand the genetic control of these traits and can be useful to include them into the genetic process for selecting the animals. The results showed that marker assited selection is ...Características economicamente importantes, como as características de carcaça, medidas post mortem, não vem sendo incluídas nos programas de melhoramento da raça Nelore devido, dentre outros fatores, aos altos custos e dificuldade de mensuração. Com a genômica, torna-se possível a seleção dos animais sem a necessidade de mensuração de seus próprios fenótipos e/ou de seus parentes, e tem-se, também, a possibilidade da realização da busca por genes ou regiões cromossômicas envolvidas com a expressão das características, por meio do estudo de associação genômica ampla (GWAS). Objetivou-se com o presente trabalho comparar diferentes modelos quanto à habilidade de predição de valores genéticos genômicos (GEBVs), e realizar um estudo de associação genômica ampla para as características: peso de carcaça quente, área de olho de lombo e espessura de gordura subcutânea, visando trazer subsídios para a incorporação da informação genômica nas avaliações genéticas de bovinos de corte no Brasil. Foram utilizados dados fenotípicos e genotípicos de 1.756 animais machos da raça Nelore. Os animais foram genotipados com um painel de alta densidade com 777.962 SNPs. Os GEBVs foram preditos utilizando três modelos: Regressão de cumeeira - (Bayesian Ridge Regression - BRR), BayesC (BC) e Lasso Bayesiano - (Bayesian Lasso - BL) e dois tipos de variáveis resposta: o valor genético tradicional e o fenótipo corrigido para os efeitos fixos. A implementação da GWAS foi realizada através da aplicação de um modelo poligênico-genômico, que considerou, simultaneamente, todas as informações disponíveis (fenótipos, pedigree e SNPs) por meio de um processo que combina a matriz de parentesco aditivo com a matriz de parentesco genômico. No geral, foi verificado que as predições genômicas sofreram influência da herdabilidade das características e do tipo de pseudo-fenótipo utilizado, sendo a...Universidade Estadual Paulista (Unesp)Albuquerque, Lucia Galvão de [UNESP]Universidade Estadual Paulista (Unesp)Fernandes Júnior, Gerardo Alves [UNESP]2015-06-17T19:33:32Z2015-06-17T19:33:32Z2015-02-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisiv, 71 p.application/pdfFERNANDES JÚNIOR, Gerardo Alves. Seleção genômica para características de carcaça em bovinos da raça Nelore. 2015. iv, 71 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias, 2015.http://hdl.handle.net/11449/123656000834736http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/08-06-2015/000834736.pdf33004102030P45866981114947883Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-06-05T18:32:47Zoai:repositorio.unesp.br:11449/123656Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:36:43.297818Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
title |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
spellingShingle |
Seleção genômica para características de carcaça em bovinos da raça Nelore Fernandes Júnior, Gerardo Alves [UNESP] Bovino de corte Nelore (Zebu) Bovino de corte - Carcaças Genômica Marcadores genéticos Genetica animal Genomics |
title_short |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
title_full |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
title_fullStr |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
title_full_unstemmed |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
title_sort |
Seleção genômica para características de carcaça em bovinos da raça Nelore |
author |
Fernandes Júnior, Gerardo Alves [UNESP] |
author_facet |
Fernandes Júnior, Gerardo Alves [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Albuquerque, Lucia Galvão de [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fernandes Júnior, Gerardo Alves [UNESP] |
dc.subject.por.fl_str_mv |
Bovino de corte Nelore (Zebu) Bovino de corte - Carcaças Genômica Marcadores genéticos Genetica animal Genomics |
topic |
Bovino de corte Nelore (Zebu) Bovino de corte - Carcaças Genômica Marcadores genéticos Genetica animal Genomics |
description |
Economic relevant traits as carcass, measured after slaughter, are not included in the animal breeding program of Nelore breed due to the difficult and high cost to measure. With the advent of genomic selection, it is possible to select animals without the need of recording phenotypic performance of its own or from close relatives, and there is also the possibility of investigating genes or chromosome regions affecting the expression of traits using genome-wide association study (GWAS). The aim of this study was to compare different models on the predictive ability of genomic breeding values (GEBVs), and to perform a GWAS for the following traits: hot carcass weight, rib eye area, and backfat thickness, in order to contribute to the incorporation of genomic information into the genetic evaluation of beef cattle in Brazil. Genotypic and phenotypic information of 1,756 Nelore bulls were used in the analysis. Genotypes were generated based on a panel with 777.962 SNPs. The GEBVs were predicted using three models: Bayesian Ridge Regression (BRR), BayesC (BC) e Bayesian Lasso (BL), and two types of response variables: estimated breeding value and adjusted phenotypes for the fixed effects. GWAS was performed using the singlestep approach which combines all available phenotypic, pedigree and genomic information adjusting a polygenic-genomic model. In general, it was verified that heritability and response variable affected the genomic predictions, where the adjusted phenotype was the most appropriate response variable to perform SNPs estimates. It was also observed that the predictive abilities were similar among the methods (BRR, BC and BL). GWAS study detected potential genome regions that may be affecting the phenotypes. These regions can contribute to understand the genetic control of these traits and can be useful to include them into the genetic process for selecting the animals. The results showed that marker assited selection is ... |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-17T19:33:32Z 2015-06-17T19:33:32Z 2015-02-24 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FERNANDES JÚNIOR, Gerardo Alves. Seleção genômica para características de carcaça em bovinos da raça Nelore. 2015. iv, 71 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias, 2015. http://hdl.handle.net/11449/123656 000834736 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/08-06-2015/000834736.pdf 33004102030P4 5866981114947883 |
identifier_str_mv |
FERNANDES JÚNIOR, Gerardo Alves. Seleção genômica para características de carcaça em bovinos da raça Nelore. 2015. iv, 71 p. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias, 2015. 000834736 33004102030P4 5866981114947883 |
url |
http://hdl.handle.net/11449/123656 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/08-06-2015/000834736.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
iv, 71 p. application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
Aleph reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129341503045632 |