Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1242/bio.030981 http://hdl.handle.net/11449/186553 |
Resumo: | The inverse relationship between serum cholesterol and levels of aggression led to the cholesterol-serotonin hypothesis. According to this hypothesis, low dietary cholesterol intake leads to depressed central serotonergic activity, which is associated with increased aggression. Here we present the hypothesis about the evolutionary origins of low cholesterol and aggressive behavior, investigating the relationship between low levels of plasma cholesterol and aggressive behavior in fish. We used Nile tilapia (Oreochromis niloticus), a species of aggressive fish with a clear dominant subordinate relation, as an experimental model. The fish were treated with statin, a cholesterol-lowering drug. Aggressive behavior, brain serotonin (5-HT) concentrations, 5-hydroxyindoleacetic acid (5-HIM, the major 5-HT metabolite) and plasma cholesterol were analyzed after chronic administration of statin. Our results show that fish treated with statin exhibited reduced plasma cholesterol, reduced telencephalic indexes of 5-HIAA/5-HT and increased aggressive behavior compared to control fish. These results indicate that changes in plasma cholesterol may affect neurochemical processes underlying aggressive behavior in fish, suggesting an evolutionary mechanism conserved among vertebrates. Such mechanisms may be important for the control of aggression in many vertebrate species, not just mammals, as has been demonstrated so far. |
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Repositório Institucional da UNESP |
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Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fishPlasma cholesterolAggressive behaviorDominance hierarchySerotonergic actionStalinThe inverse relationship between serum cholesterol and levels of aggression led to the cholesterol-serotonin hypothesis. According to this hypothesis, low dietary cholesterol intake leads to depressed central serotonergic activity, which is associated with increased aggression. Here we present the hypothesis about the evolutionary origins of low cholesterol and aggressive behavior, investigating the relationship between low levels of plasma cholesterol and aggressive behavior in fish. We used Nile tilapia (Oreochromis niloticus), a species of aggressive fish with a clear dominant subordinate relation, as an experimental model. The fish were treated with statin, a cholesterol-lowering drug. Aggressive behavior, brain serotonin (5-HT) concentrations, 5-hydroxyindoleacetic acid (5-HIM, the major 5-HT metabolite) and plasma cholesterol were analyzed after chronic administration of statin. Our results show that fish treated with statin exhibited reduced plasma cholesterol, reduced telencephalic indexes of 5-HIAA/5-HT and increased aggressive behavior compared to control fish. These results indicate that changes in plasma cholesterol may affect neurochemical processes underlying aggressive behavior in fish, suggesting an evolutionary mechanism conserved among vertebrates. Such mechanisms may be important for the control of aggression in many vertebrate species, not just mammals, as has been demonstrated so far.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ, Biosci Inst, Physiol Dept, BR-18618689 Sao Paulo, BrazilSao Paulo State Univ, Biosci Inst, Physiol Dept, BR-18618689 Sao Paulo, BrazilFAPESP: 2009/05372-8Company Biologists LtdUniversidade Estadual Paulista (Unesp)Aguiar, Ariane [UNESP]Giaquinto, Percilia Cardoso [UNESP]2019-10-05T06:04:16Z2019-10-05T06:04:16Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6http://dx.doi.org/10.1242/bio.030981Biology Open. Cambridge: Company Biologists Ltd, v. 7, n. 12, 6 p., 2018.2046-6390http://hdl.handle.net/11449/18655310.1242/bio.030981WOS:00045469720000259867844357279800000-0003-4591-4415Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiology Openinfo:eu-repo/semantics/openAccess2021-10-23T20:17:59Zoai:repositorio.unesp.br:11449/186553Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:04:56.712168Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
title |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
spellingShingle |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish Aguiar, Ariane [UNESP] Plasma cholesterol Aggressive behavior Dominance hierarchy Serotonergic action Stalin |
title_short |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
title_full |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
title_fullStr |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
title_full_unstemmed |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
title_sort |
Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish |
author |
Aguiar, Ariane [UNESP] |
author_facet |
Aguiar, Ariane [UNESP] Giaquinto, Percilia Cardoso [UNESP] |
author_role |
author |
author2 |
Giaquinto, Percilia Cardoso [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Aguiar, Ariane [UNESP] Giaquinto, Percilia Cardoso [UNESP] |
dc.subject.por.fl_str_mv |
Plasma cholesterol Aggressive behavior Dominance hierarchy Serotonergic action Stalin |
topic |
Plasma cholesterol Aggressive behavior Dominance hierarchy Serotonergic action Stalin |
description |
The inverse relationship between serum cholesterol and levels of aggression led to the cholesterol-serotonin hypothesis. According to this hypothesis, low dietary cholesterol intake leads to depressed central serotonergic activity, which is associated with increased aggression. Here we present the hypothesis about the evolutionary origins of low cholesterol and aggressive behavior, investigating the relationship between low levels of plasma cholesterol and aggressive behavior in fish. We used Nile tilapia (Oreochromis niloticus), a species of aggressive fish with a clear dominant subordinate relation, as an experimental model. The fish were treated with statin, a cholesterol-lowering drug. Aggressive behavior, brain serotonin (5-HT) concentrations, 5-hydroxyindoleacetic acid (5-HIM, the major 5-HT metabolite) and plasma cholesterol were analyzed after chronic administration of statin. Our results show that fish treated with statin exhibited reduced plasma cholesterol, reduced telencephalic indexes of 5-HIAA/5-HT and increased aggressive behavior compared to control fish. These results indicate that changes in plasma cholesterol may affect neurochemical processes underlying aggressive behavior in fish, suggesting an evolutionary mechanism conserved among vertebrates. Such mechanisms may be important for the control of aggression in many vertebrate species, not just mammals, as has been demonstrated so far. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 2019-10-05T06:04:16Z 2019-10-05T06:04:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1242/bio.030981 Biology Open. Cambridge: Company Biologists Ltd, v. 7, n. 12, 6 p., 2018. 2046-6390 http://hdl.handle.net/11449/186553 10.1242/bio.030981 WOS:000454697200002 5986784435727980 0000-0003-4591-4415 |
url |
http://dx.doi.org/10.1242/bio.030981 http://hdl.handle.net/11449/186553 |
identifier_str_mv |
Biology Open. Cambridge: Company Biologists Ltd, v. 7, n. 12, 6 p., 2018. 2046-6390 10.1242/bio.030981 WOS:000454697200002 5986784435727980 0000-0003-4591-4415 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biology Open |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 |
dc.publisher.none.fl_str_mv |
Company Biologists Ltd |
publisher.none.fl_str_mv |
Company Biologists Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129581189693440 |