Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0185572 http://hdl.handle.net/11449/170271 |
Resumo: | The multiple insecurities, anatomical, physiological and psychological changes arising from the gestational period can generate an overload of stress in the mother and cause disturbances in the offspring, affecting it throughout its development. The existing analysis linking prenatal stress and offspring’s anxiety have divergent results, being limited as to gestational week, type of stressor and age of progeny’s assessment. Social separation has been described as a stressor that causes increase in anxiety. Thus, the present study evaluated the effects of social separation applied in one of the three gestational weeks of rat dams on the manifestation of the defensive behaviors related to generalized anxiety disorder and panic in the Elevated T Maze of the male progeny in three stages of development (1, 3 or 6 months of life). It was found, in the offspring of grouped (control) dams, increased behaviors associated with generalized anxiety disorder and a reduction of panic-like behaviors throughout development. For animals whose dams were socially separated during pregnancy, the most critical period of exposure was the 2nd gestational week, which affected the acquisition of aversive memory, demonstrated by the impairment on learning of avoidances of the offspring in all ages evaluated. Stressor exposure in this week also increased the avoidances, related to generalized anxiety of progeny in the 1st month and decreased escapes, related to panic in the 3rd month of life and, at the age of 6 months old, an inverse situation, with the reduction of the defensive behaviors associated to generalized anxiety disorder. The results show that, when assessing effects of prenatal stress on the manifestation of anxiety, not only the period of exposure is important, but also the age of offspring assessed. |
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spelling |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring developmentThe multiple insecurities, anatomical, physiological and psychological changes arising from the gestational period can generate an overload of stress in the mother and cause disturbances in the offspring, affecting it throughout its development. The existing analysis linking prenatal stress and offspring’s anxiety have divergent results, being limited as to gestational week, type of stressor and age of progeny’s assessment. Social separation has been described as a stressor that causes increase in anxiety. Thus, the present study evaluated the effects of social separation applied in one of the three gestational weeks of rat dams on the manifestation of the defensive behaviors related to generalized anxiety disorder and panic in the Elevated T Maze of the male progeny in three stages of development (1, 3 or 6 months of life). It was found, in the offspring of grouped (control) dams, increased behaviors associated with generalized anxiety disorder and a reduction of panic-like behaviors throughout development. For animals whose dams were socially separated during pregnancy, the most critical period of exposure was the 2nd gestational week, which affected the acquisition of aversive memory, demonstrated by the impairment on learning of avoidances of the offspring in all ages evaluated. Stressor exposure in this week also increased the avoidances, related to generalized anxiety of progeny in the 1st month and decreased escapes, related to panic in the 3rd month of life and, at the age of 6 months old, an inverse situation, with the reduction of the defensive behaviors associated to generalized anxiety disorder. The results show that, when assessing effects of prenatal stress on the manifestation of anxiety, not only the period of exposure is important, but also the age of offspring assessed.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratory of Physiology UNESP–Univ Estadual PaulistaDepartment of Biological Science Laboratory of Physiology UNESP–Univ Estadual PaulistaLaboratory of Physiology UNESP–Univ Estadual PaulistaDepartment of Biological Science Laboratory of Physiology UNESP–Univ Estadual PaulistaFAPESP: 2012/19973-6FAPESP: 2013/10808-5Universidade Estadual Paulista (Unesp)Soliani, Flaviane Cristina De Brito Guzzo [UNESP]Cabbia, Rafael [UNESP]Batistela, Matheus Fitipaldi [UNESP]Almeida, Amarylis Garcia [UNESP]Kümpel, Vinícius Dias [UNESP]Yamauchi, Luiz [UNESP]De Andrade, Telma Gonçalves Carneiro Spera [UNESP]2018-12-11T16:50:02Z2018-12-11T16:50:02Z2017-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1371/journal.pone.0185572PLoS ONE, v. 12, n. 10, 2017.1932-6203http://hdl.handle.net/11449/17027110.1371/journal.pone.01855722-s2.0-850313286042-s2.0-85031328604.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONE1,164info:eu-repo/semantics/openAccess2023-11-04T06:08:36Zoai:repositorio.unesp.br:11449/170271Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:53:10.114351Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
title |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
spellingShingle |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development Soliani, Flaviane Cristina De Brito Guzzo [UNESP] |
title_short |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
title_full |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
title_fullStr |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
title_full_unstemmed |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
title_sort |
Impact of social separation during pregnancy on the manifestation of defensive behaviors related to generalized anxiety and panic throughout offspring development |
author |
Soliani, Flaviane Cristina De Brito Guzzo [UNESP] |
author_facet |
Soliani, Flaviane Cristina De Brito Guzzo [UNESP] Cabbia, Rafael [UNESP] Batistela, Matheus Fitipaldi [UNESP] Almeida, Amarylis Garcia [UNESP] Kümpel, Vinícius Dias [UNESP] Yamauchi, Luiz [UNESP] De Andrade, Telma Gonçalves Carneiro Spera [UNESP] |
author_role |
author |
author2 |
Cabbia, Rafael [UNESP] Batistela, Matheus Fitipaldi [UNESP] Almeida, Amarylis Garcia [UNESP] Kümpel, Vinícius Dias [UNESP] Yamauchi, Luiz [UNESP] De Andrade, Telma Gonçalves Carneiro Spera [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Soliani, Flaviane Cristina De Brito Guzzo [UNESP] Cabbia, Rafael [UNESP] Batistela, Matheus Fitipaldi [UNESP] Almeida, Amarylis Garcia [UNESP] Kümpel, Vinícius Dias [UNESP] Yamauchi, Luiz [UNESP] De Andrade, Telma Gonçalves Carneiro Spera [UNESP] |
description |
The multiple insecurities, anatomical, physiological and psychological changes arising from the gestational period can generate an overload of stress in the mother and cause disturbances in the offspring, affecting it throughout its development. The existing analysis linking prenatal stress and offspring’s anxiety have divergent results, being limited as to gestational week, type of stressor and age of progeny’s assessment. Social separation has been described as a stressor that causes increase in anxiety. Thus, the present study evaluated the effects of social separation applied in one of the three gestational weeks of rat dams on the manifestation of the defensive behaviors related to generalized anxiety disorder and panic in the Elevated T Maze of the male progeny in three stages of development (1, 3 or 6 months of life). It was found, in the offspring of grouped (control) dams, increased behaviors associated with generalized anxiety disorder and a reduction of panic-like behaviors throughout development. For animals whose dams were socially separated during pregnancy, the most critical period of exposure was the 2nd gestational week, which affected the acquisition of aversive memory, demonstrated by the impairment on learning of avoidances of the offspring in all ages evaluated. Stressor exposure in this week also increased the avoidances, related to generalized anxiety of progeny in the 1st month and decreased escapes, related to panic in the 3rd month of life and, at the age of 6 months old, an inverse situation, with the reduction of the defensive behaviors associated to generalized anxiety disorder. The results show that, when assessing effects of prenatal stress on the manifestation of anxiety, not only the period of exposure is important, but also the age of offspring assessed. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 2018-12-11T16:50:02Z 2018-12-11T16:50:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0185572 PLoS ONE, v. 12, n. 10, 2017. 1932-6203 http://hdl.handle.net/11449/170271 10.1371/journal.pone.0185572 2-s2.0-85031328604 2-s2.0-85031328604.pdf |
url |
http://dx.doi.org/10.1371/journal.pone.0185572 http://hdl.handle.net/11449/170271 |
identifier_str_mv |
PLoS ONE, v. 12, n. 10, 2017. 1932-6203 10.1371/journal.pone.0185572 2-s2.0-85031328604 2-s2.0-85031328604.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS ONE 1,164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128715514707968 |