Transcriptional and Posttranscriptional Regulations of the HLA-G Gene
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/734068 http://hdl.handle.net/11449/112291 |
Resumo: | HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-gamma and NF-kappa B, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident. At least three variable sites in the 3' untranslated region have been studied that may influence HLA-G expression by modifying mRNA stability or microRNA binding sites, including the 14-base pair insertion/deletion, +3142C/G and +3187A/G polymorphisms. Other polymorphic sites have been described, but there are no functional studies on them. The HLA-G coding region polymorphisms might influence isoform production and at least two null alleles with premature stop codons have been described. We reviewed the structure of the HLA-G promoter region and its implication in transcriptional gene control, the structure of the HLA-G 3' UTR and the major actors of the posttranscriptional gene control, and, finally, the presence of regulatory elements in the coding region. |
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Transcriptional and Posttranscriptional Regulations of the HLA-G GeneHLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-gamma and NF-kappa B, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident. At least three variable sites in the 3' untranslated region have been studied that may influence HLA-G expression by modifying mRNA stability or microRNA binding sites, including the 14-base pair insertion/deletion, +3142C/G and +3187A/G polymorphisms. Other polymorphic sites have been described, but there are no functional studies on them. The HLA-G coding region polymorphisms might influence isoform production and at least two null alleles with premature stop codons have been described. We reviewed the structure of the HLA-G promoter region and its implication in transcriptional gene control, the structure of the HLA-G 3' UTR and the major actors of the posttranscriptional gene control, and, finally, the presence of regulatory elements in the coding region.Univ Estadual Paulista UNESP, Dept Patol, Fac Med Botucatu, BR-18618970 Botucatu, SP, BrazilUniv Sao Paulo, Div Clin Immunol, Dept Med, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, BrazilSt Louis Hosp, Alternat Energies & Atom Energy Commiss, Inst Emerging Dis & Innovat Therapies, Dept Hematol & Immunol Res, F-75010 Paris, FranceParis Diderot Univ, Univ Inst Hematol, St Louis Hosp, Sorbonne Paris Cite,UMR E5, F-75010 Paris, FranceUniv Estadual Paulista UNESP, Dept Patol, Fac Med Botucatu, BR-18618970 Botucatu, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)St Louis HospParis Diderot UnivCastelli, Erick da Cruz [UNESP]Veiga-Castelli, Luciana C.Yaghi, LayaleMoreau, PhilippeDonadi, Eduardo A.2014-12-03T13:10:35Z2014-12-03T13:10:35Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://dx.doi.org/10.1155/2014/734068Journal Of Immunology Research. New York: Hindawi Publishing Corporation, 15 p., 2014.1740-2522http://hdl.handle.net/11449/11229110.1155/2014/734068WOS:000333265800001WOS000333265800001.pdf09925593181752350000-0003-2142-7196Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Immunology Researchinfo:eu-repo/semantics/openAccess2023-11-21T06:10:02Zoai:repositorio.unesp.br:11449/112291Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-21T06:10:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
title |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
spellingShingle |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene Castelli, Erick da Cruz [UNESP] |
title_short |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
title_full |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
title_fullStr |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
title_full_unstemmed |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
title_sort |
Transcriptional and Posttranscriptional Regulations of the HLA-G Gene |
author |
Castelli, Erick da Cruz [UNESP] |
author_facet |
Castelli, Erick da Cruz [UNESP] Veiga-Castelli, Luciana C. Yaghi, Layale Moreau, Philippe Donadi, Eduardo A. |
author_role |
author |
author2 |
Veiga-Castelli, Luciana C. Yaghi, Layale Moreau, Philippe Donadi, Eduardo A. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) St Louis Hosp Paris Diderot Univ |
dc.contributor.author.fl_str_mv |
Castelli, Erick da Cruz [UNESP] Veiga-Castelli, Luciana C. Yaghi, Layale Moreau, Philippe Donadi, Eduardo A. |
description |
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-gamma and NF-kappa B, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident. At least three variable sites in the 3' untranslated region have been studied that may influence HLA-G expression by modifying mRNA stability or microRNA binding sites, including the 14-base pair insertion/deletion, +3142C/G and +3187A/G polymorphisms. Other polymorphic sites have been described, but there are no functional studies on them. The HLA-G coding region polymorphisms might influence isoform production and at least two null alleles with premature stop codons have been described. We reviewed the structure of the HLA-G promoter region and its implication in transcriptional gene control, the structure of the HLA-G 3' UTR and the major actors of the posttranscriptional gene control, and, finally, the presence of regulatory elements in the coding region. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:10:35Z 2014-12-03T13:10:35Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/734068 Journal Of Immunology Research. New York: Hindawi Publishing Corporation, 15 p., 2014. 1740-2522 http://hdl.handle.net/11449/112291 10.1155/2014/734068 WOS:000333265800001 WOS000333265800001.pdf 0992559318175235 0000-0003-2142-7196 |
url |
http://dx.doi.org/10.1155/2014/734068 http://hdl.handle.net/11449/112291 |
identifier_str_mv |
Journal Of Immunology Research. New York: Hindawi Publishing Corporation, 15 p., 2014. 1740-2522 10.1155/2014/734068 WOS:000333265800001 WOS000333265800001.pdf 0992559318175235 0000-0003-2142-7196 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Immunology Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046588144156672 |