Maternal body mass index affects embryo morphokinetics: a time-lapse study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10815-019-01456-3 http://hdl.handle.net/11449/185857 |
Resumo: | PurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D.ResultsAfter adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84h (46.31-55.29) vs. 49.24h (45.69-53.22) and 57.89h (51.60-65.94) vs. 55.66h (50.89-62.89), adjusted p<0.05 and adjusted p<0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72h (51.83-63.92) vs. 55.66h (50.89-62.89), adjusted p<0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR=2.1; 95% CI 1.12-3.95, adjusted p<0.05).ConclusionAssessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development. |
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Repositório Institucional da UNESP |
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Maternal body mass index affects embryo morphokinetics: a time-lapse studyBMIEmbryo developmentMorphokineticsTime-lapsePurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D.ResultsAfter adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84h (46.31-55.29) vs. 49.24h (45.69-53.22) and 57.89h (51.60-65.94) vs. 55.66h (50.89-62.89), adjusted p<0.05 and adjusted p<0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72h (51.83-63.92) vs. 55.66h (50.89-62.89), adjusted p<0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR=2.1; 95% CI 1.12-3.95, adjusted p<0.05).ConclusionAssessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development.Biogenesi, Reprod Med Ctr, Monza, ItalySao Paulo State Univ, Ovarian Mol Physiol Lab, Dept Physiol, Inst Biosci, Botucatu, SP, BrazilSao Paulo State Univ, Ovarian Mol Physiol Lab, Dept Physiol, Inst Biosci, Botucatu, SP, BrazilSpringerBiogenesiUniversidade Estadual Paulista (Unesp)Bartolacci, AlessandroBuratini, Jose [UNESP]Moutier, ClarissaGuglielmo, Maria CristinaNovara, Paola VittoriaBrambillasca, FaustaRenzini, Mario MigniniDal Canto, Mariabeatrice2019-10-04T12:39:11Z2019-10-04T12:39:11Z2019-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1109-1116http://dx.doi.org/10.1007/s10815-019-01456-3Journal Of Assisted Reproduction And Genetics. New York: Springer/plenum Publishers, v. 36, n. 6, p. 1109-1116, 2019.1058-0468http://hdl.handle.net/11449/18585710.1007/s10815-019-01456-3WOS:000473503000009Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Assisted Reproduction And Geneticsinfo:eu-repo/semantics/openAccess2021-10-23T16:08:59Zoai:repositorio.unesp.br:11449/185857Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:39:25.168743Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
title |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
spellingShingle |
Maternal body mass index affects embryo morphokinetics: a time-lapse study Bartolacci, Alessandro BMI Embryo development Morphokinetics Time-lapse |
title_short |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
title_full |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
title_fullStr |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
title_full_unstemmed |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
title_sort |
Maternal body mass index affects embryo morphokinetics: a time-lapse study |
author |
Bartolacci, Alessandro |
author_facet |
Bartolacci, Alessandro Buratini, Jose [UNESP] Moutier, Clarissa Guglielmo, Maria Cristina Novara, Paola Vittoria Brambillasca, Fausta Renzini, Mario Mignini Dal Canto, Mariabeatrice |
author_role |
author |
author2 |
Buratini, Jose [UNESP] Moutier, Clarissa Guglielmo, Maria Cristina Novara, Paola Vittoria Brambillasca, Fausta Renzini, Mario Mignini Dal Canto, Mariabeatrice |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Biogenesi Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bartolacci, Alessandro Buratini, Jose [UNESP] Moutier, Clarissa Guglielmo, Maria Cristina Novara, Paola Vittoria Brambillasca, Fausta Renzini, Mario Mignini Dal Canto, Mariabeatrice |
dc.subject.por.fl_str_mv |
BMI Embryo development Morphokinetics Time-lapse |
topic |
BMI Embryo development Morphokinetics Time-lapse |
description |
PurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D.ResultsAfter adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84h (46.31-55.29) vs. 49.24h (45.69-53.22) and 57.89h (51.60-65.94) vs. 55.66h (50.89-62.89), adjusted p<0.05 and adjusted p<0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72h (51.83-63.92) vs. 55.66h (50.89-62.89), adjusted p<0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR=2.1; 95% CI 1.12-3.95, adjusted p<0.05).ConclusionAssessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:39:11Z 2019-10-04T12:39:11Z 2019-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10815-019-01456-3 Journal Of Assisted Reproduction And Genetics. New York: Springer/plenum Publishers, v. 36, n. 6, p. 1109-1116, 2019. 1058-0468 http://hdl.handle.net/11449/185857 10.1007/s10815-019-01456-3 WOS:000473503000009 |
url |
http://dx.doi.org/10.1007/s10815-019-01456-3 http://hdl.handle.net/11449/185857 |
identifier_str_mv |
Journal Of Assisted Reproduction And Genetics. New York: Springer/plenum Publishers, v. 36, n. 6, p. 1109-1116, 2019. 1058-0468 10.1007/s10815-019-01456-3 WOS:000473503000009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Assisted Reproduction And Genetics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1109-1116 |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128961836744704 |