Maternal body mass index affects embryo morphokinetics: a time-lapse study

Detalhes bibliográficos
Autor(a) principal: Bartolacci, Alessandro
Data de Publicação: 2019
Outros Autores: Buratini, Jose [UNESP], Moutier, Clarissa, Guglielmo, Maria Cristina, Novara, Paola Vittoria, Brambillasca, Fausta, Renzini, Mario Mignini, Dal Canto, Mariabeatrice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10815-019-01456-3
http://hdl.handle.net/11449/185857
Resumo: PurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D.ResultsAfter adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84h (46.31-55.29) vs. 49.24h (45.69-53.22) and 57.89h (51.60-65.94) vs. 55.66h (50.89-62.89), adjusted p<0.05 and adjusted p<0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72h (51.83-63.92) vs. 55.66h (50.89-62.89), adjusted p<0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR=2.1; 95% CI 1.12-3.95, adjusted p<0.05).ConclusionAssessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development.
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spelling Maternal body mass index affects embryo morphokinetics: a time-lapse studyBMIEmbryo developmentMorphokineticsTime-lapsePurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D.ResultsAfter adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84h (46.31-55.29) vs. 49.24h (45.69-53.22) and 57.89h (51.60-65.94) vs. 55.66h (50.89-62.89), adjusted p<0.05 and adjusted p<0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72h (51.83-63.92) vs. 55.66h (50.89-62.89), adjusted p<0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR=2.1; 95% CI 1.12-3.95, adjusted p<0.05).ConclusionAssessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development.Biogenesi, Reprod Med Ctr, Monza, ItalySao Paulo State Univ, Ovarian Mol Physiol Lab, Dept Physiol, Inst Biosci, Botucatu, SP, BrazilSao Paulo State Univ, Ovarian Mol Physiol Lab, Dept Physiol, Inst Biosci, Botucatu, SP, BrazilSpringerBiogenesiUniversidade Estadual Paulista (Unesp)Bartolacci, AlessandroBuratini, Jose [UNESP]Moutier, ClarissaGuglielmo, Maria CristinaNovara, Paola VittoriaBrambillasca, FaustaRenzini, Mario MigniniDal Canto, Mariabeatrice2019-10-04T12:39:11Z2019-10-04T12:39:11Z2019-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1109-1116http://dx.doi.org/10.1007/s10815-019-01456-3Journal Of Assisted Reproduction And Genetics. New York: Springer/plenum Publishers, v. 36, n. 6, p. 1109-1116, 2019.1058-0468http://hdl.handle.net/11449/18585710.1007/s10815-019-01456-3WOS:000473503000009Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Assisted Reproduction And Geneticsinfo:eu-repo/semantics/openAccess2021-10-23T16:08:59Zoai:repositorio.unesp.br:11449/185857Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:39:25.168743Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Maternal body mass index affects embryo morphokinetics: a time-lapse study
title Maternal body mass index affects embryo morphokinetics: a time-lapse study
spellingShingle Maternal body mass index affects embryo morphokinetics: a time-lapse study
Bartolacci, Alessandro
BMI
Embryo development
Morphokinetics
Time-lapse
title_short Maternal body mass index affects embryo morphokinetics: a time-lapse study
title_full Maternal body mass index affects embryo morphokinetics: a time-lapse study
title_fullStr Maternal body mass index affects embryo morphokinetics: a time-lapse study
title_full_unstemmed Maternal body mass index affects embryo morphokinetics: a time-lapse study
title_sort Maternal body mass index affects embryo morphokinetics: a time-lapse study
author Bartolacci, Alessandro
author_facet Bartolacci, Alessandro
Buratini, Jose [UNESP]
Moutier, Clarissa
Guglielmo, Maria Cristina
Novara, Paola Vittoria
Brambillasca, Fausta
Renzini, Mario Mignini
Dal Canto, Mariabeatrice
author_role author
author2 Buratini, Jose [UNESP]
Moutier, Clarissa
Guglielmo, Maria Cristina
Novara, Paola Vittoria
Brambillasca, Fausta
Renzini, Mario Mignini
Dal Canto, Mariabeatrice
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biogenesi
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Bartolacci, Alessandro
Buratini, Jose [UNESP]
Moutier, Clarissa
Guglielmo, Maria Cristina
Novara, Paola Vittoria
Brambillasca, Fausta
Renzini, Mario Mignini
Dal Canto, Mariabeatrice
dc.subject.por.fl_str_mv BMI
Embryo development
Morphokinetics
Time-lapse
topic BMI
Embryo development
Morphokinetics
Time-lapse
description PurposeTo assess the effect of body mass index (BMI) on morphokinetic parameters of human embryos evaluated with time-lapse technology during in vitro culture.MethodsA retrospective analysis of ART cycles utilizing time-lapse technology was undertaken to assess the potential impact of maternal BMI on morphokinetic and static morphological parameters of embryo development. The cohort of patients was divided into four groups: 593 embryos from 128 underweight women in group A; 5248 embryos from 1107 normal weight women in group B; 1053 embryos from 226 overweight women in group C; and 286 embryos from 67 obese women in group D.ResultsAfter adjusting for maternal age, paternal age, and cause of infertility, time to reach five blastomeres (t5) and time to reach eight blastomeres (t8) were longer in obese women compared with normoweight women [50.84h (46.31-55.29) vs. 49.24h (45.69-53.22) and 57.89h (51.60-65.94) vs. 55.66h (50.89-62.89), adjusted p<0.05 and adjusted p<0.01, respectively]. In addition, t8 was also delayed in overweight compared with normoweight women [56.72h (51.83-63.92) vs. 55.66h (50.89-62.89), adjusted p<0.01]. No significant differences were observed among groups with regard to embryo morphology and pregnancy rate. Miscarriage rate was higher in underweight compared with normoweight women (OR=2.1; 95% CI 1.12-3.95, adjusted p<0.05).ConclusionAssessment with time-lapse technology but not by classical static morphology evidences that maternal BMI affects embryo development. Maternal obesity and overweight are associated with slower embryo development.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:39:11Z
2019-10-04T12:39:11Z
2019-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10815-019-01456-3
Journal Of Assisted Reproduction And Genetics. New York: Springer/plenum Publishers, v. 36, n. 6, p. 1109-1116, 2019.
1058-0468
http://hdl.handle.net/11449/185857
10.1007/s10815-019-01456-3
WOS:000473503000009
url http://dx.doi.org/10.1007/s10815-019-01456-3
http://hdl.handle.net/11449/185857
identifier_str_mv Journal Of Assisted Reproduction And Genetics. New York: Springer/plenum Publishers, v. 36, n. 6, p. 1109-1116, 2019.
1058-0468
10.1007/s10815-019-01456-3
WOS:000473503000009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Assisted Reproduction And Genetics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1109-1116
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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