CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/245318 |
Resumo: | Ingestion of sodium and/or water is controlled by excitatory mechanisms that involve stimuli like angiotensin II (ANG II), mineralocorticoids or hiperosmolarity acting on specific areas of the brain and by inhibitory mechanisms present in different central areas and involving different hormones and neurotransmitters that act to limit these behaviors. Recent studies have shown two important inhibitory mechanisms for the control of sodium and water intake: the inhibitory mechanism of the lateral parabrachial nucleus (LPBN) and the alpha(2) adrenergic mechanism located in forebrain areas. In the LPBN different neurotransmitters like serotonin, cholecystokinin, glutamate, corticotropin-releasing factor, GABA and opioid may modulate the inhibitory mechanism. Interactions between neurotransmitters in the LPBN, like the interdependence and cooperactivity between serotonin and cholecystokinin have also been demonstrated. In the forebrain, mixed alpha(2)-adrenergic and imidazoline receptor agonists, like clonidine and moxonidine, are the most effective to inhibit water and sodium intake induced by different stimuli. Inhibition of water or NaCl intake dependent on alpha(2)-adrenergic receptor activation has been demonstrated with injection of these drugs into the lateral ventricle (LV), septal area, lateral preoptic area, and lateral hypothalamus. Previous and unpublished results presented in this chapter have shown that: A) in normovolemic rats, moxonidine injected into the LV induced c-fos expression in the organum vasculosum lamina terminalis (OVLT), ventral median preoptic nucleus (vMPN), paraventricular and supraoptic nucleus of the hypothalamus, while in sodium depleted rats, moxonidine reduced c-fos expression in the OVLT and increases it in the dorsal MPN; B) moxonidine bilaterally injected into basal amygdala (BA) reduced sodium depletion-induced sodium intake, while no effects were observed injecting moxonidine into the central amygdala; C) moxonidine into the LV reduced water and sodium intake and hypertension induced by daily subcutaneous (sc) injection of deoxycorticosterone; D) moxonidine injected into the LV also reduced food intake-induced water intake, but did not change food deprivation-induced food intake, suggesting that inhibitory effects of moxonidine in the forebrain are not due to non specific inhibition of behaviors; E) contrary to the inhibitory effects produced by injections into the amygdala, LV or other forebrain areas, bilateral injections of moxonidine into the LPBN increases sodium intake. |
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CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKEthirstsodium appetitelateral parabrachial nucleusalpha(2)-adrenoceptorsserotoninmoxonidineIngestion of sodium and/or water is controlled by excitatory mechanisms that involve stimuli like angiotensin II (ANG II), mineralocorticoids or hiperosmolarity acting on specific areas of the brain and by inhibitory mechanisms present in different central areas and involving different hormones and neurotransmitters that act to limit these behaviors. Recent studies have shown two important inhibitory mechanisms for the control of sodium and water intake: the inhibitory mechanism of the lateral parabrachial nucleus (LPBN) and the alpha(2) adrenergic mechanism located in forebrain areas. In the LPBN different neurotransmitters like serotonin, cholecystokinin, glutamate, corticotropin-releasing factor, GABA and opioid may modulate the inhibitory mechanism. Interactions between neurotransmitters in the LPBN, like the interdependence and cooperactivity between serotonin and cholecystokinin have also been demonstrated. In the forebrain, mixed alpha(2)-adrenergic and imidazoline receptor agonists, like clonidine and moxonidine, are the most effective to inhibit water and sodium intake induced by different stimuli. Inhibition of water or NaCl intake dependent on alpha(2)-adrenergic receptor activation has been demonstrated with injection of these drugs into the lateral ventricle (LV), septal area, lateral preoptic area, and lateral hypothalamus. Previous and unpublished results presented in this chapter have shown that: A) in normovolemic rats, moxonidine injected into the LV induced c-fos expression in the organum vasculosum lamina terminalis (OVLT), ventral median preoptic nucleus (vMPN), paraventricular and supraoptic nucleus of the hypothalamus, while in sodium depleted rats, moxonidine reduced c-fos expression in the OVLT and increases it in the dorsal MPN; B) moxonidine bilaterally injected into basal amygdala (BA) reduced sodium depletion-induced sodium intake, while no effects were observed injecting moxonidine into the central amygdala; C) moxonidine into the LV reduced water and sodium intake and hypertension induced by daily subcutaneous (sc) injection of deoxycorticosterone; D) moxonidine injected into the LV also reduced food intake-induced water intake, but did not change food deprivation-induced food intake, suggesting that inhibitory effects of moxonidine in the forebrain are not due to non specific inhibition of behaviors; E) contrary to the inhibitory effects produced by injections into the amygdala, LV or other forebrain areas, bilateral injections of moxonidine into the LPBN increases sodium intake.Sao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilUniv Fed Alfenas, Unifal MG, Dept Biomed Sci, Alfenas, MG, BrazilUniv Fed Ouro Preto, DECBI NUPEB, Dept Biol Sci, Ouro Preto, MG, BrazilSao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilNova Science Publishers, IncUniversidade Estadual Paulista (UNESP)Univ Fed AlfenasUniv Fed Ouro PretoMenani, Jose Vanderlei [UNESP]De Luca, Laurival Antonio [UNESP]Paula, Patricia Maria de [UNESP]Fabricio de Andrade, Carina Aparecida [UNESP]Oliveira, Lisandra Brandino de [UNESP]Ferreira da Silva, Daniela Catelan [UNESP]Ellsworth, S. J.Schuster, R. C.2023-07-29T11:51:23Z2023-07-29T11:51:23Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article107-135Appetite and Nutritional Assessment. Hauppauge: Nova Science Publishers, Inc, p. 107-135, 2009.http://hdl.handle.net/11449/245318WOS:000273354100003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAppetite And Nutritional Assessmentinfo:eu-repo/semantics/openAccess2023-07-29T11:51:23Zoai:repositorio.unesp.br:11449/245318Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T11:51:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
title |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
spellingShingle |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE Menani, Jose Vanderlei [UNESP] thirst sodium appetite lateral parabrachial nucleus alpha(2)-adrenoceptors serotonin moxonidine |
title_short |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
title_full |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
title_fullStr |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
title_full_unstemmed |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
title_sort |
CENTRAL INHIBITORY MECHANISMS CONTROLLING WATER AND SODIUM INTAKE |
author |
Menani, Jose Vanderlei [UNESP] |
author_facet |
Menani, Jose Vanderlei [UNESP] De Luca, Laurival Antonio [UNESP] Paula, Patricia Maria de [UNESP] Fabricio de Andrade, Carina Aparecida [UNESP] Oliveira, Lisandra Brandino de [UNESP] Ferreira da Silva, Daniela Catelan [UNESP] Ellsworth, S. J. Schuster, R. C. |
author_role |
author |
author2 |
De Luca, Laurival Antonio [UNESP] Paula, Patricia Maria de [UNESP] Fabricio de Andrade, Carina Aparecida [UNESP] Oliveira, Lisandra Brandino de [UNESP] Ferreira da Silva, Daniela Catelan [UNESP] Ellsworth, S. J. Schuster, R. C. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Univ Fed Alfenas Univ Fed Ouro Preto |
dc.contributor.author.fl_str_mv |
Menani, Jose Vanderlei [UNESP] De Luca, Laurival Antonio [UNESP] Paula, Patricia Maria de [UNESP] Fabricio de Andrade, Carina Aparecida [UNESP] Oliveira, Lisandra Brandino de [UNESP] Ferreira da Silva, Daniela Catelan [UNESP] Ellsworth, S. J. Schuster, R. C. |
dc.subject.por.fl_str_mv |
thirst sodium appetite lateral parabrachial nucleus alpha(2)-adrenoceptors serotonin moxonidine |
topic |
thirst sodium appetite lateral parabrachial nucleus alpha(2)-adrenoceptors serotonin moxonidine |
description |
Ingestion of sodium and/or water is controlled by excitatory mechanisms that involve stimuli like angiotensin II (ANG II), mineralocorticoids or hiperosmolarity acting on specific areas of the brain and by inhibitory mechanisms present in different central areas and involving different hormones and neurotransmitters that act to limit these behaviors. Recent studies have shown two important inhibitory mechanisms for the control of sodium and water intake: the inhibitory mechanism of the lateral parabrachial nucleus (LPBN) and the alpha(2) adrenergic mechanism located in forebrain areas. In the LPBN different neurotransmitters like serotonin, cholecystokinin, glutamate, corticotropin-releasing factor, GABA and opioid may modulate the inhibitory mechanism. Interactions between neurotransmitters in the LPBN, like the interdependence and cooperactivity between serotonin and cholecystokinin have also been demonstrated. In the forebrain, mixed alpha(2)-adrenergic and imidazoline receptor agonists, like clonidine and moxonidine, are the most effective to inhibit water and sodium intake induced by different stimuli. Inhibition of water or NaCl intake dependent on alpha(2)-adrenergic receptor activation has been demonstrated with injection of these drugs into the lateral ventricle (LV), septal area, lateral preoptic area, and lateral hypothalamus. Previous and unpublished results presented in this chapter have shown that: A) in normovolemic rats, moxonidine injected into the LV induced c-fos expression in the organum vasculosum lamina terminalis (OVLT), ventral median preoptic nucleus (vMPN), paraventricular and supraoptic nucleus of the hypothalamus, while in sodium depleted rats, moxonidine reduced c-fos expression in the OVLT and increases it in the dorsal MPN; B) moxonidine bilaterally injected into basal amygdala (BA) reduced sodium depletion-induced sodium intake, while no effects were observed injecting moxonidine into the central amygdala; C) moxonidine into the LV reduced water and sodium intake and hypertension induced by daily subcutaneous (sc) injection of deoxycorticosterone; D) moxonidine injected into the LV also reduced food intake-induced water intake, but did not change food deprivation-induced food intake, suggesting that inhibitory effects of moxonidine in the forebrain are not due to non specific inhibition of behaviors; E) contrary to the inhibitory effects produced by injections into the amygdala, LV or other forebrain areas, bilateral injections of moxonidine into the LPBN increases sodium intake. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2023-07-29T11:51:23Z 2023-07-29T11:51:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Appetite and Nutritional Assessment. Hauppauge: Nova Science Publishers, Inc, p. 107-135, 2009. http://hdl.handle.net/11449/245318 WOS:000273354100003 |
identifier_str_mv |
Appetite and Nutritional Assessment. Hauppauge: Nova Science Publishers, Inc, p. 107-135, 2009. WOS:000273354100003 |
url |
http://hdl.handle.net/11449/245318 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Appetite And Nutritional Assessment |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
107-135 |
dc.publisher.none.fl_str_mv |
Nova Science Publishers, Inc |
publisher.none.fl_str_mv |
Nova Science Publishers, Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964610981265408 |