Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2017.01.011 http://hdl.handle.net/11449/162844 |
Resumo: | Peritonitis in horses persists with high incidence and mortality, requiring more innovative and effective therapeutic strategies. The aim of this study was to evaluate Tenckhoff catheters and intraperitoneal use of ceftriaxone in horses. Ten healthy, male horses, with an average age of 5 years, were used and divided into two groups of five animals each. A Tenckhoff catheter was implanted in both groups. The intraperitoneal group received 25 mg/kg of ceftriaxone diluted in 1 L of 0.9% saline solution (SS) intraperitoneally via the Tenckhoff catheter, and the intravenous group received 25 mg/kg of ceftriaxone intravenously and 1 L of SS intraperitoneally. In both groups, the dosing interval was every 24 hours for 5 days. The animals were evaluated clinically and with laboratory tests through a blood count and plasma fibrinogen assay. A macroscopic, physical-chemical, and cytological evaluation of the peritoneal fluid and an abdominal sonographic evaluation were conducted before the catheter implantation and at 1, 3, 5, 7, and 10 days after the implantation and ceftriaxone administration. Seven days after the catheter insertion and the beginning of the intraperitoneal treatment, a laparoscopic evaluation was performed. The Tenckhoff catheter proved to be an appropriate route for intraperitoneal solution administration; however, it promoted a moderate inflammatory response in the abdomen. No differences in inflammatory reaction was observed between groups, suggesting that the intraperitoneal administration of the drug did not trigger a local or systemic inflammatory process, amplifying the possibilities of intraperitoneal route utilization in the treatment of peritonitis. (C) 2017 Elsevier Inc. All rights reserved. |
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Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in HorsesAntibioticsCephalosporinsPeritoneal catheterPeritonitisPeritonitis in horses persists with high incidence and mortality, requiring more innovative and effective therapeutic strategies. The aim of this study was to evaluate Tenckhoff catheters and intraperitoneal use of ceftriaxone in horses. Ten healthy, male horses, with an average age of 5 years, were used and divided into two groups of five animals each. A Tenckhoff catheter was implanted in both groups. The intraperitoneal group received 25 mg/kg of ceftriaxone diluted in 1 L of 0.9% saline solution (SS) intraperitoneally via the Tenckhoff catheter, and the intravenous group received 25 mg/kg of ceftriaxone intravenously and 1 L of SS intraperitoneally. In both groups, the dosing interval was every 24 hours for 5 days. The animals were evaluated clinically and with laboratory tests through a blood count and plasma fibrinogen assay. A macroscopic, physical-chemical, and cytological evaluation of the peritoneal fluid and an abdominal sonographic evaluation were conducted before the catheter implantation and at 1, 3, 5, 7, and 10 days after the implantation and ceftriaxone administration. Seven days after the catheter insertion and the beginning of the intraperitoneal treatment, a laparoscopic evaluation was performed. The Tenckhoff catheter proved to be an appropriate route for intraperitoneal solution administration; however, it promoted a moderate inflammatory response in the abdomen. No differences in inflammatory reaction was observed between groups, suggesting that the intraperitoneal administration of the drug did not trigger a local or systemic inflammatory process, amplifying the possibilities of intraperitoneal route utilization in the treatment of peritonitis. (C) 2017 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, Sao Paulo, BrazilUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Clin, Sao Paulo, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Sao Paulo, BrazilUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, Sao Paulo, BrazilUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Clin, Sao Paulo, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Sao Paulo, BrazilFAPESP: 2013/13799-7Elsevier B.V.Universidade Estadual Paulista (Unesp)Alonso, Juliana de Moura [UNESP]Nitta, Thiago Yukio [UNESP]Mizucina Akutagawa, Tatiana Yumi [UNESP]Crescencio, Amanda Paulino [UNESP]Takahira, Regina Kiomi [UNESP]Santos, Bruna dos [UNESP]Garcia Alves, Ana Liz [UNESP]Watanabe, Marcos Jun [UNESP]Rodrigues, Celso Antonio [UNESP]Peccinini, Rosangela Goncalves [UNESP]Campos, Michel Leandro de [UNESP]Hussni, Carlos Alberto [UNESP]2018-11-26T17:34:38Z2018-11-26T17:34:38Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article55-63application/pdfhttp://dx.doi.org/10.1016/j.jevs.2017.01.011Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 53, p. 55-63, 2017.0737-0806http://hdl.handle.net/11449/16284410.1016/j.jevs.2017.01.011WOS:000402472700007WOS000402472700007.pdf7989397951395253Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Equine Veterinary Science0,390info:eu-repo/semantics/openAccess2024-06-24T14:51:28Zoai:repositorio.unesp.br:11449/162844Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:23:39.176339Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
title |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
spellingShingle |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses Alonso, Juliana de Moura [UNESP] Antibiotics Cephalosporins Peritoneal catheter Peritonitis |
title_short |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
title_full |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
title_fullStr |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
title_full_unstemmed |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
title_sort |
Evaluation of Tenckhoff Catheter Use and Ceftriaxone Intraperitoneal Administration in Horses |
author |
Alonso, Juliana de Moura [UNESP] |
author_facet |
Alonso, Juliana de Moura [UNESP] Nitta, Thiago Yukio [UNESP] Mizucina Akutagawa, Tatiana Yumi [UNESP] Crescencio, Amanda Paulino [UNESP] Takahira, Regina Kiomi [UNESP] Santos, Bruna dos [UNESP] Garcia Alves, Ana Liz [UNESP] Watanabe, Marcos Jun [UNESP] Rodrigues, Celso Antonio [UNESP] Peccinini, Rosangela Goncalves [UNESP] Campos, Michel Leandro de [UNESP] Hussni, Carlos Alberto [UNESP] |
author_role |
author |
author2 |
Nitta, Thiago Yukio [UNESP] Mizucina Akutagawa, Tatiana Yumi [UNESP] Crescencio, Amanda Paulino [UNESP] Takahira, Regina Kiomi [UNESP] Santos, Bruna dos [UNESP] Garcia Alves, Ana Liz [UNESP] Watanabe, Marcos Jun [UNESP] Rodrigues, Celso Antonio [UNESP] Peccinini, Rosangela Goncalves [UNESP] Campos, Michel Leandro de [UNESP] Hussni, Carlos Alberto [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alonso, Juliana de Moura [UNESP] Nitta, Thiago Yukio [UNESP] Mizucina Akutagawa, Tatiana Yumi [UNESP] Crescencio, Amanda Paulino [UNESP] Takahira, Regina Kiomi [UNESP] Santos, Bruna dos [UNESP] Garcia Alves, Ana Liz [UNESP] Watanabe, Marcos Jun [UNESP] Rodrigues, Celso Antonio [UNESP] Peccinini, Rosangela Goncalves [UNESP] Campos, Michel Leandro de [UNESP] Hussni, Carlos Alberto [UNESP] |
dc.subject.por.fl_str_mv |
Antibiotics Cephalosporins Peritoneal catheter Peritonitis |
topic |
Antibiotics Cephalosporins Peritoneal catheter Peritonitis |
description |
Peritonitis in horses persists with high incidence and mortality, requiring more innovative and effective therapeutic strategies. The aim of this study was to evaluate Tenckhoff catheters and intraperitoneal use of ceftriaxone in horses. Ten healthy, male horses, with an average age of 5 years, were used and divided into two groups of five animals each. A Tenckhoff catheter was implanted in both groups. The intraperitoneal group received 25 mg/kg of ceftriaxone diluted in 1 L of 0.9% saline solution (SS) intraperitoneally via the Tenckhoff catheter, and the intravenous group received 25 mg/kg of ceftriaxone intravenously and 1 L of SS intraperitoneally. In both groups, the dosing interval was every 24 hours for 5 days. The animals were evaluated clinically and with laboratory tests through a blood count and plasma fibrinogen assay. A macroscopic, physical-chemical, and cytological evaluation of the peritoneal fluid and an abdominal sonographic evaluation were conducted before the catheter implantation and at 1, 3, 5, 7, and 10 days after the implantation and ceftriaxone administration. Seven days after the catheter insertion and the beginning of the intraperitoneal treatment, a laparoscopic evaluation was performed. The Tenckhoff catheter proved to be an appropriate route for intraperitoneal solution administration; however, it promoted a moderate inflammatory response in the abdomen. No differences in inflammatory reaction was observed between groups, suggesting that the intraperitoneal administration of the drug did not trigger a local or systemic inflammatory process, amplifying the possibilities of intraperitoneal route utilization in the treatment of peritonitis. (C) 2017 Elsevier Inc. All rights reserved. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 2018-11-26T17:34:38Z 2018-11-26T17:34:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2017.01.011 Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 53, p. 55-63, 2017. 0737-0806 http://hdl.handle.net/11449/162844 10.1016/j.jevs.2017.01.011 WOS:000402472700007 WOS000402472700007.pdf 7989397951395253 |
url |
http://dx.doi.org/10.1016/j.jevs.2017.01.011 http://hdl.handle.net/11449/162844 |
identifier_str_mv |
Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 53, p. 55-63, 2017. 0737-0806 10.1016/j.jevs.2017.01.011 WOS:000402472700007 WOS000402472700007.pdf 7989397951395253 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Equine Veterinary Science 0,390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
55-63 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128507568455680 |