Proteinograma sérico de cães sadios e com linfoma obtido por eletroforese em gel de poliacrilamida (SDS-PAGE)

• Autor(a) principal: Calazans, S. G. [UNESP]
• Data de Publicação: 2009
• Outros Autores: Daleck, C. R. [UNESP], Fagliari, J. J. [UNESP], Repetti, C. F., De Nardi, A. B., Castro, J. H.T. [UNESP], Fernandes, S. C. [UNESP], César, J. R.F. [UNESP], Rodigheri, S. M. [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0102-09352009000500005; http://hdl.handle.net/11449/231910
• topic: Dog; Lymphoma; Serum protein

Blood serum samples of ten healthy dogs and 12 dogs with lymphoma were evaluated by means of sodium dodecil sulphate-polyacrylamide gel electrophoresis. There was difference in total protein concentrations among healthy dogs, 7.68g/dL±0.46 and dogs with lymphoma, 7.93g/dL±2.49 values of immunoglobulins A and G presented no difference between groups. Serum proteins with molecular weights 142,000; 110,000; 52,000; 49,000; 24,000; and 18,000 Daltons presented increased concentrations in dogs with lymphoma. Dogs with lymphoma presented increased ceruloplasmin (43.95mg/dL±18.19) and haptoglobin (554mg/dL±449.51) values and lesser albumin concentration (2,908mg/dL±476.67) when compared to healthy dogs (ceruloplasmin: 3.42mg/dL±7.44; haptoglobin: 94.54mg/dL±59.50, and albumin: 4,207mg/dL±206.18). In conclusion, increased ceruloplasmin and haptoglobin and lesser albumin serum concentrations are possibly related to lymphoma in dogs.