Prevenção de hemoglobinopatias a partir do estudo em gestantes
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.1590/S1516-84842001000100005 |
Texto Completo: | http://dx.doi.org/10.1590/S1516-84842001000100005 http://hdl.handle.net/11449/66693 |
Resumo: | The Brazilian population, presents genes for abnormal hemoglobins with variable frequencies, which are influenced by the founding racial groups. Thus, the detection of carriers of the genetic alterations is important for public health, since they represent sources of new beterozygotes and possible homozygotes. The control of the hemoglobin pathologies has been possible by means of genetic counseling and early diagnosis. The clinical follow-up of the homozygotes and the orientation of the beterozygotes and especially the couples at risk represent a more effective mode of acting to avoid the birth of children who are carriers of a genetic disease, that is frequently lethal. For these reasons this work had as its objectives: to evaluate the importance of testing in pregnant women for the detection of hemoglobin pathologies with the purpose of investigating the prevalence, attaining prevention, a familial study and awareness; for the positive cases such as couples at risk, orient as to appropriate medical attendance; and to evaluate the response to the program. Of the total of 696 pregnant women analysed, 10.7% revealed hemoglobin pathologies with the following rates: alpha Thalassemia 6.75%; Hb AS 2.01%; beta minor Thalassemia 1.29%; Hb AC 0.28%; Hb AJ 0.14%; Hb AS/Alpha Thalassemia 0.14% and P.H.H.F. 0.14%. The high rates of hemoglobin pathologies encountered in the population of pregnant women studied shows the necessity of the implantation of tests for these abnormalities in the pre-natal routine, since in this period the mothers are more apt to be preoccupied with their own health and that of their babies and, however earlier diagnosed the alterations in the hemoglobins, better and more adequate will be the orientations given the couple. |
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Prevenção de hemoglobinopatias a partir do estudo em gestantesHemoglobinopathies: A study in pregnancyAbnormal hemoglobinHemoglobinopathies in pregnantsThalassemiaThe Brazilian population, presents genes for abnormal hemoglobins with variable frequencies, which are influenced by the founding racial groups. Thus, the detection of carriers of the genetic alterations is important for public health, since they represent sources of new beterozygotes and possible homozygotes. The control of the hemoglobin pathologies has been possible by means of genetic counseling and early diagnosis. The clinical follow-up of the homozygotes and the orientation of the beterozygotes and especially the couples at risk represent a more effective mode of acting to avoid the birth of children who are carriers of a genetic disease, that is frequently lethal. For these reasons this work had as its objectives: to evaluate the importance of testing in pregnant women for the detection of hemoglobin pathologies with the purpose of investigating the prevalence, attaining prevention, a familial study and awareness; for the positive cases such as couples at risk, orient as to appropriate medical attendance; and to evaluate the response to the program. Of the total of 696 pregnant women analysed, 10.7% revealed hemoglobin pathologies with the following rates: alpha Thalassemia 6.75%; Hb AS 2.01%; beta minor Thalassemia 1.29%; Hb AC 0.28%; Hb AJ 0.14%; Hb AS/Alpha Thalassemia 0.14% and P.H.H.F. 0.14%. The high rates of hemoglobin pathologies encountered in the population of pregnant women studied shows the necessity of the implantation of tests for these abnormalities in the pre-natal routine, since in this period the mothers are more apt to be preoccupied with their own health and that of their babies and, however earlier diagnosed the alterations in the hemoglobins, better and more adequate will be the orientations given the couple.Laboratório de Anemias Departamento de Biologia UNHSP, São José do Rio PretoLaboratório de Anemias Departamento de Biologia UNESP, Sào José do Rio Preto-SPHemocentro de Sào José do Rio Preto-SPLaboratorio 1 Instituto Adolfo Lutz, Sào José do Rio Preto, Rua Moacir Terra Sóssio, 371, CEP: 15170.000. Tanabi. SPLaboratório de Anemias Departamento de Biologia UNESP, Sào José do Rio Preto-SPUNHSPUniversidade Estadual Paulista (Unesp)Hemocentro de Sào José do Rio Preto-SPInstituto Adolfo Lutz (IAL)Viana-Baracioli, Lígia M. S. [UNESP]Bonini-Domingos, Cláudia R. [UNESP]Pagliusi, Regina A.Naoum, Paulo C. [UNESP]2014-05-27T11:20:21Z2014-05-27T11:20:21Z2001-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article31-39application/pdfhttp://dx.doi.org/10.1590/S1516-84842001000100005Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 31-39, 2001.1516-8484http://hdl.handle.net/11449/6669310.1590/S1516-84842001000100005S1516-848420010001000052-s2.0-337473360912-s2.0-33747336091.pdf32794280661767190000-0002-4603-9467Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Hematologia e Hemoterapia0,335info:eu-repo/semantics/openAccess2024-01-29T06:26:40Zoai:repositorio.unesp.br:11449/66693Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:12:22.056635Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Prevenção de hemoglobinopatias a partir do estudo em gestantes Hemoglobinopathies: A study in pregnancy |
title |
Prevenção de hemoglobinopatias a partir do estudo em gestantes |
spellingShingle |
Prevenção de hemoglobinopatias a partir do estudo em gestantes Prevenção de hemoglobinopatias a partir do estudo em gestantes Viana-Baracioli, Lígia M. S. [UNESP] Abnormal hemoglobin Hemoglobinopathies in pregnants Thalassemia Viana-Baracioli, Lígia M. S. [UNESP] Abnormal hemoglobin Hemoglobinopathies in pregnants Thalassemia |
title_short |
Prevenção de hemoglobinopatias a partir do estudo em gestantes |
title_full |
Prevenção de hemoglobinopatias a partir do estudo em gestantes |
title_fullStr |
Prevenção de hemoglobinopatias a partir do estudo em gestantes Prevenção de hemoglobinopatias a partir do estudo em gestantes |
title_full_unstemmed |
Prevenção de hemoglobinopatias a partir do estudo em gestantes Prevenção de hemoglobinopatias a partir do estudo em gestantes |
title_sort |
Prevenção de hemoglobinopatias a partir do estudo em gestantes |
author |
Viana-Baracioli, Lígia M. S. [UNESP] |
author_facet |
Viana-Baracioli, Lígia M. S. [UNESP] Viana-Baracioli, Lígia M. S. [UNESP] Bonini-Domingos, Cláudia R. [UNESP] Pagliusi, Regina A. Naoum, Paulo C. [UNESP] Bonini-Domingos, Cláudia R. [UNESP] Pagliusi, Regina A. Naoum, Paulo C. [UNESP] |
author_role |
author |
author2 |
Bonini-Domingos, Cláudia R. [UNESP] Pagliusi, Regina A. Naoum, Paulo C. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
UNHSP Universidade Estadual Paulista (Unesp) Hemocentro de Sào José do Rio Preto-SP Instituto Adolfo Lutz (IAL) |
dc.contributor.author.fl_str_mv |
Viana-Baracioli, Lígia M. S. [UNESP] Bonini-Domingos, Cláudia R. [UNESP] Pagliusi, Regina A. Naoum, Paulo C. [UNESP] |
dc.subject.por.fl_str_mv |
Abnormal hemoglobin Hemoglobinopathies in pregnants Thalassemia |
topic |
Abnormal hemoglobin Hemoglobinopathies in pregnants Thalassemia |
description |
The Brazilian population, presents genes for abnormal hemoglobins with variable frequencies, which are influenced by the founding racial groups. Thus, the detection of carriers of the genetic alterations is important for public health, since they represent sources of new beterozygotes and possible homozygotes. The control of the hemoglobin pathologies has been possible by means of genetic counseling and early diagnosis. The clinical follow-up of the homozygotes and the orientation of the beterozygotes and especially the couples at risk represent a more effective mode of acting to avoid the birth of children who are carriers of a genetic disease, that is frequently lethal. For these reasons this work had as its objectives: to evaluate the importance of testing in pregnant women for the detection of hemoglobin pathologies with the purpose of investigating the prevalence, attaining prevention, a familial study and awareness; for the positive cases such as couples at risk, orient as to appropriate medical attendance; and to evaluate the response to the program. Of the total of 696 pregnant women analysed, 10.7% revealed hemoglobin pathologies with the following rates: alpha Thalassemia 6.75%; Hb AS 2.01%; beta minor Thalassemia 1.29%; Hb AC 0.28%; Hb AJ 0.14%; Hb AS/Alpha Thalassemia 0.14% and P.H.H.F. 0.14%. The high rates of hemoglobin pathologies encountered in the population of pregnant women studied shows the necessity of the implantation of tests for these abnormalities in the pre-natal routine, since in this period the mothers are more apt to be preoccupied with their own health and that of their babies and, however earlier diagnosed the alterations in the hemoglobins, better and more adequate will be the orientations given the couple. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-12-01 2014-05-27T11:20:21Z 2014-05-27T11:20:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-84842001000100005 Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 31-39, 2001. 1516-8484 http://hdl.handle.net/11449/66693 10.1590/S1516-84842001000100005 S1516-84842001000100005 2-s2.0-33747336091 2-s2.0-33747336091.pdf 3279428066176719 0000-0002-4603-9467 |
url |
http://dx.doi.org/10.1590/S1516-84842001000100005 http://hdl.handle.net/11449/66693 |
identifier_str_mv |
Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 31-39, 2001. 1516-8484 10.1590/S1516-84842001000100005 S1516-84842001000100005 2-s2.0-33747336091 2-s2.0-33747336091.pdf 3279428066176719 0000-0002-4603-9467 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia 0,335 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
31-39 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1822182246793084928 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1516-84842001000100005 |