Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg

Detalhes bibliográficos
Autor(a) principal: Cruz, José Roquennedy Souza
Data de Publicação: 2009
Outros Autores: Cruz, Denise Ferreira Barroso de Melo, Branco, Bruno Castelo, Santiago, Ana Ellen de Queiroz, Do Amaral, José Luiz Gomes [UNESP]
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0034-70942009000600005
http://hdl.handle.net/11449/71221
Resumo: BACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the degree of sedation, intraocular pressure, and hemodynamic changes with premedication with low doses of oral clonidine, 100 μg and 200 μg, in outpatient cataract surgeries. METHODS: This is a randomized, double-blind, clinical study undertaken at the Universidade Federal de São Paulo with 60 patients of both genders, physical status ASA 1 and 2, ages 18 to 80 years. Patients were separated into three groups: placebo, clonidine 100 μg, and clonidine 200 μg. Intraocular pressure, heart rate, and blood pressure besides assessment of sedation were measured before and 90 minutes after the administration of clonidine. Sedation levels were classified according to the Ramsay sedation scale. RESULTS: Patients who received placebo and 100 μg of clonidine did not show reduction in heart rate, while a reduction in heart rate was observed in patients who received 200 μg of clonidine, and this difference was statistically significant. Patients who received 200 μg of clonidine also had a reduction in systolic and diastolic blood pressure (p < 0.05). One patient who received 200 μg of clonidine developed severe hypotension, with systolic pressure < 80 mmHg. Patients treated with clonidine had a reduction in intraocular pressure (p < 0.05). Ninety minutes after the oral administration of placebo and 100 μg and 200 μg of clonidine, 25%, 60%, and 80% of the patients respectively were classified as Ramsay 3 or 4. CONCLUSIONS: Clonidine 100 μg can be indicated as premedication for fasciectomies, being effective in sedation and reduction of intraocular pressure, without adverse effects on blood pressure and heart rate.
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spelling Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μgClonidine as pre-anesthetic medication in cataract extration: Comparison between 100 μg and 200 μgComplications: intraocular pressurePremedication: clonidineSurgery, ophthalmologic: cataract extrationclonidineplaceboadultagedambulatory surgeryblood pressureblood pressure measurementcataract extractionclinical evaluationclinical trialcontrolled clinical trialcontrolled studydiastolic blood pressuredouble blind proceduredrug dose comparisonfemaleheart ratehumanhypotensionintraocular pressurelow drug dosemajor clinical studymalemydriasisphacoemulsificationpremedicationramsay sedation scalerandomized controlled trialrating scalesedationside effectsurgical patientsystolic blood pressureAnalgesicsCataract ExtractionClonidineDouble-Blind MethodFemaleHumansMaleMiddle AgedPreanesthetic MedicationBACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the degree of sedation, intraocular pressure, and hemodynamic changes with premedication with low doses of oral clonidine, 100 μg and 200 μg, in outpatient cataract surgeries. METHODS: This is a randomized, double-blind, clinical study undertaken at the Universidade Federal de São Paulo with 60 patients of both genders, physical status ASA 1 and 2, ages 18 to 80 years. Patients were separated into three groups: placebo, clonidine 100 μg, and clonidine 200 μg. Intraocular pressure, heart rate, and blood pressure besides assessment of sedation were measured before and 90 minutes after the administration of clonidine. Sedation levels were classified according to the Ramsay sedation scale. RESULTS: Patients who received placebo and 100 μg of clonidine did not show reduction in heart rate, while a reduction in heart rate was observed in patients who received 200 μg of clonidine, and this difference was statistically significant. Patients who received 200 μg of clonidine also had a reduction in systolic and diastolic blood pressure (p < 0.05). One patient who received 200 μg of clonidine developed severe hypotension, with systolic pressure < 80 mmHg. Patients treated with clonidine had a reduction in intraocular pressure (p < 0.05). Ninety minutes after the oral administration of placebo and 100 μg and 200 μg of clonidine, 25%, 60%, and 80% of the patients respectively were classified as Ramsay 3 or 4. CONCLUSIONS: Clonidine 100 μg can be indicated as premedication for fasciectomies, being effective in sedation and reduction of intraocular pressure, without adverse effects on blood pressure and heart rate.Universidade Federal de SergipeAssociação Brasileira de Medicina IntensivaInstituto de Olhos de Sergipe - Ocular Day HospitalUNIFESPConselho Brasileiro de OftalmologiaUniversidade Federal da BahiaUniversidade Federal de RondôniaAMIBEscola Paulista de MedicinaFaculdade de Medicina de Botucatu-UNESPFaculdade de Medicina de Botucatu-UNESPUniversidade Federal de Sergipe (UFS)Associação Brasileira de Medicina IntensivaInstituto de Olhos de Sergipe - Ocular Day HospitalUniversidade Federal de São Paulo (UNIFESP)Conselho Brasileiro de OftalmologiaUniversidade Federal da Bahia (UFBA)Universidade Federal de Rondônia (UNIR)AMIBEscola Paulista de MedicinaUniversidade Estadual Paulista (Unesp)Cruz, José Roquennedy SouzaCruz, Denise Ferreira Barroso de MeloBranco, Bruno CasteloSantiago, Ana Ellen de QueirozDo Amaral, José Luiz Gomes [UNESP]2014-05-27T11:24:01Z2014-05-27T11:24:01Z2009-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article694-703application/pdfhttp://dx.doi.org/10.1590/S0034-70942009000600005Revista Brasileira de Anestesiologia, v. 59, n. 6, p. 694-703, 2009.0034-70941806-907Xhttp://hdl.handle.net/11449/7122110.1590/S0034-70942009000600005S0034-709420090006000052-s2.0-734490981832-s2.0-73449098183.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporengRevista Brasileira de Anestesiologia0.8500,320info:eu-repo/semantics/openAccess2023-12-11T06:14:14Zoai:repositorio.unesp.br:11449/71221Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:01:51.466046Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
Clonidine as pre-anesthetic medication in cataract extration: Comparison between 100 μg and 200 μg
title Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
spellingShingle Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
Cruz, José Roquennedy Souza
Complications: intraocular pressure
Premedication: clonidine
Surgery, ophthalmologic: cataract extration
clonidine
placebo
adult
aged
ambulatory surgery
blood pressure
blood pressure measurement
cataract extraction
clinical evaluation
clinical trial
controlled clinical trial
controlled study
diastolic blood pressure
double blind procedure
drug dose comparison
female
heart rate
human
hypotension
intraocular pressure
low drug dose
major clinical study
male
mydriasis
phacoemulsification
premedication
ramsay sedation scale
randomized controlled trial
rating scale
sedation
side effect
surgical patient
systolic blood pressure
Analgesics
Cataract Extraction
Clonidine
Double-Blind Method
Female
Humans
Male
Middle Aged
Preanesthetic Medication
title_short Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
title_full Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
title_fullStr Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
title_full_unstemmed Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
title_sort Clonidina como medicação pré-anestésica em facectomias: Comparação entre as doses de 100 μg e 200 μg
author Cruz, José Roquennedy Souza
author_facet Cruz, José Roquennedy Souza
Cruz, Denise Ferreira Barroso de Melo
Branco, Bruno Castelo
Santiago, Ana Ellen de Queiroz
Do Amaral, José Luiz Gomes [UNESP]
author_role author
author2 Cruz, Denise Ferreira Barroso de Melo
Branco, Bruno Castelo
Santiago, Ana Ellen de Queiroz
Do Amaral, José Luiz Gomes [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Sergipe (UFS)
Associação Brasileira de Medicina Intensiva
Instituto de Olhos de Sergipe - Ocular Day Hospital
Universidade Federal de São Paulo (UNIFESP)
Conselho Brasileiro de Oftalmologia
Universidade Federal da Bahia (UFBA)
Universidade Federal de Rondônia (UNIR)
AMIB
Escola Paulista de Medicina
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Cruz, José Roquennedy Souza
Cruz, Denise Ferreira Barroso de Melo
Branco, Bruno Castelo
Santiago, Ana Ellen de Queiroz
Do Amaral, José Luiz Gomes [UNESP]
dc.subject.por.fl_str_mv Complications: intraocular pressure
Premedication: clonidine
Surgery, ophthalmologic: cataract extration
clonidine
placebo
adult
aged
ambulatory surgery
blood pressure
blood pressure measurement
cataract extraction
clinical evaluation
clinical trial
controlled clinical trial
controlled study
diastolic blood pressure
double blind procedure
drug dose comparison
female
heart rate
human
hypotension
intraocular pressure
low drug dose
major clinical study
male
mydriasis
phacoemulsification
premedication
ramsay sedation scale
randomized controlled trial
rating scale
sedation
side effect
surgical patient
systolic blood pressure
Analgesics
Cataract Extraction
Clonidine
Double-Blind Method
Female
Humans
Male
Middle Aged
Preanesthetic Medication
topic Complications: intraocular pressure
Premedication: clonidine
Surgery, ophthalmologic: cataract extration
clonidine
placebo
adult
aged
ambulatory surgery
blood pressure
blood pressure measurement
cataract extraction
clinical evaluation
clinical trial
controlled clinical trial
controlled study
diastolic blood pressure
double blind procedure
drug dose comparison
female
heart rate
human
hypotension
intraocular pressure
low drug dose
major clinical study
male
mydriasis
phacoemulsification
premedication
ramsay sedation scale
randomized controlled trial
rating scale
sedation
side effect
surgical patient
systolic blood pressure
Analgesics
Cataract Extraction
Clonidine
Double-Blind Method
Female
Humans
Male
Middle Aged
Preanesthetic Medication
description BACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the degree of sedation, intraocular pressure, and hemodynamic changes with premedication with low doses of oral clonidine, 100 μg and 200 μg, in outpatient cataract surgeries. METHODS: This is a randomized, double-blind, clinical study undertaken at the Universidade Federal de São Paulo with 60 patients of both genders, physical status ASA 1 and 2, ages 18 to 80 years. Patients were separated into three groups: placebo, clonidine 100 μg, and clonidine 200 μg. Intraocular pressure, heart rate, and blood pressure besides assessment of sedation were measured before and 90 minutes after the administration of clonidine. Sedation levels were classified according to the Ramsay sedation scale. RESULTS: Patients who received placebo and 100 μg of clonidine did not show reduction in heart rate, while a reduction in heart rate was observed in patients who received 200 μg of clonidine, and this difference was statistically significant. Patients who received 200 μg of clonidine also had a reduction in systolic and diastolic blood pressure (p < 0.05). One patient who received 200 μg of clonidine developed severe hypotension, with systolic pressure < 80 mmHg. Patients treated with clonidine had a reduction in intraocular pressure (p < 0.05). Ninety minutes after the oral administration of placebo and 100 μg and 200 μg of clonidine, 25%, 60%, and 80% of the patients respectively were classified as Ramsay 3 or 4. CONCLUSIONS: Clonidine 100 μg can be indicated as premedication for fasciectomies, being effective in sedation and reduction of intraocular pressure, without adverse effects on blood pressure and heart rate.
publishDate 2009
dc.date.none.fl_str_mv 2009-11-01
2014-05-27T11:24:01Z
2014-05-27T11:24:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0034-70942009000600005
Revista Brasileira de Anestesiologia, v. 59, n. 6, p. 694-703, 2009.
0034-7094
1806-907X
http://hdl.handle.net/11449/71221
10.1590/S0034-70942009000600005
S0034-70942009000600005
2-s2.0-73449098183
2-s2.0-73449098183.pdf
url http://dx.doi.org/10.1590/S0034-70942009000600005
http://hdl.handle.net/11449/71221
identifier_str_mv Revista Brasileira de Anestesiologia, v. 59, n. 6, p. 694-703, 2009.
0034-7094
1806-907X
10.1590/S0034-70942009000600005
S0034-70942009000600005
2-s2.0-73449098183
2-s2.0-73449098183.pdf
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv Revista Brasileira de Anestesiologia
0.850
0,320
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 694-703
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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