Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema

Detalhes bibliográficos
Autor(a) principal: Ribeiro-Paes, Joao Tadeu [UNESP]
Data de Publicação: 2011
Outros Autores: Bilaqui, Aldemir, Greco, Oswaldo T., Ruiz, Milton Artur, Marcelino, Monica Y., Stessuk, Talita [UNESP], de Faria, Carolina A., Lago, Mario R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2147/COPD.S15292
http://hdl.handle.net/11449/42545
Resumo: Within the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema presents, as a primarily histopathologic feature, the destruction of pulmonary parenchyma and, accordingly, an increase in the airflow obstruction distal to the terminal bronchiole. Notwithstanding the significant advances in prevention and treatment of symptoms, no effective or curative therapy has been accomplished. In this context, cellular therapy with stem cells (SCs) arises as a new therapeutic approach, with a wide application potential. The -purpose of this study is to evaluate the safety of SCs infusion procedure in patients with advanced COPD (stage IV dyspnea). After selection, patients underwent clinical examination and received granulocyte colony-stimulating factor, immediately prior to the bone marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and infused into a peripheral vein. The 12-month follow-up showed a significant improvement in the quality of life, as well as a clinical stable condition, which suggest a change in the natural process of the disease. Therefore, the proposed methodology in this study for BMMC cell therapy in sufferers of advanced COPD was demonstrated to be free of significant adverse effects. Although a larger sample and a greater follow-up period are needed, it is possible to infer that BMMC cell therapy introduces an unprecedented change in the course or in the natural history of emphysema, inhibiting or slowing the progression of disease. This clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was approved by the Brazilian National Committee of Ethics in Research (registration no. 14764, CONEP report 233/2009).
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spelling Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysemacell therapychronic obstructive pulmonary disease COPDpulmonary emphysemaBMMCstem cellsWithin the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema presents, as a primarily histopathologic feature, the destruction of pulmonary parenchyma and, accordingly, an increase in the airflow obstruction distal to the terminal bronchiole. Notwithstanding the significant advances in prevention and treatment of symptoms, no effective or curative therapy has been accomplished. In this context, cellular therapy with stem cells (SCs) arises as a new therapeutic approach, with a wide application potential. The -purpose of this study is to evaluate the safety of SCs infusion procedure in patients with advanced COPD (stage IV dyspnea). After selection, patients underwent clinical examination and received granulocyte colony-stimulating factor, immediately prior to the bone marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and infused into a peripheral vein. The 12-month follow-up showed a significant improvement in the quality of life, as well as a clinical stable condition, which suggest a change in the natural process of the disease. Therefore, the proposed methodology in this study for BMMC cell therapy in sufferers of advanced COPD was demonstrated to be free of significant adverse effects. Although a larger sample and a greater follow-up period are needed, it is possible to infer that BMMC cell therapy introduces an unprecedented change in the course or in the natural history of emphysema, inhibiting or slowing the progression of disease. This clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was approved by the Brazilian National Committee of Ethics in Research (registration no. 14764, CONEP report 233/2009).Cardiovascular Disease Institute (IMC, Sao Jose do Rio Preto, SP, Brazil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista UNESP, Assis, SP, BrazilCardiovasc Dis Inst IMC, Sao Jose do Rio Preto, SP, BrazilUSP IPT I, Interunits Biotechnol Post Grad Program, São Paulo, BrazilUniv Estadual Paulista UNESP, Assis, SP, BrazilDove Medical Press LtdUniversidade Estadual Paulista (Unesp)Cardiovasc Dis Inst IMCUniversidade de São Paulo (USP)Ribeiro-Paes, Joao Tadeu [UNESP]Bilaqui, AldemirGreco, Oswaldo T.Ruiz, Milton ArturMarcelino, Monica Y.Stessuk, Talita [UNESP]de Faria, Carolina A.Lago, Mario R.2014-05-20T15:34:27Z2014-05-20T15:34:27Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article63-71application/pdfhttp://dx.doi.org/10.2147/COPD.S15292International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 63-71, 2011.1176-9106http://hdl.handle.net/11449/4254510.2147/COPD.S15292WOS:000208709800007WOS000208709800007.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Chronic Obstructive Pulmonary Disease1,395info:eu-repo/semantics/openAccess2023-09-30T06:04:54Zoai:repositorio.unesp.br:11449/42545Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:34:34.603637Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
title Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
spellingShingle Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
Ribeiro-Paes, Joao Tadeu [UNESP]
cell therapy
chronic obstructive pulmonary disease COPD
pulmonary emphysema
BMMC
stem cells
title_short Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
title_full Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
title_fullStr Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
title_full_unstemmed Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
title_sort Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
author Ribeiro-Paes, Joao Tadeu [UNESP]
author_facet Ribeiro-Paes, Joao Tadeu [UNESP]
Bilaqui, Aldemir
Greco, Oswaldo T.
Ruiz, Milton Artur
Marcelino, Monica Y.
Stessuk, Talita [UNESP]
de Faria, Carolina A.
Lago, Mario R.
author_role author
author2 Bilaqui, Aldemir
Greco, Oswaldo T.
Ruiz, Milton Artur
Marcelino, Monica Y.
Stessuk, Talita [UNESP]
de Faria, Carolina A.
Lago, Mario R.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Cardiovasc Dis Inst IMC
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Ribeiro-Paes, Joao Tadeu [UNESP]
Bilaqui, Aldemir
Greco, Oswaldo T.
Ruiz, Milton Artur
Marcelino, Monica Y.
Stessuk, Talita [UNESP]
de Faria, Carolina A.
Lago, Mario R.
dc.subject.por.fl_str_mv cell therapy
chronic obstructive pulmonary disease COPD
pulmonary emphysema
BMMC
stem cells
topic cell therapy
chronic obstructive pulmonary disease COPD
pulmonary emphysema
BMMC
stem cells
description Within the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema presents, as a primarily histopathologic feature, the destruction of pulmonary parenchyma and, accordingly, an increase in the airflow obstruction distal to the terminal bronchiole. Notwithstanding the significant advances in prevention and treatment of symptoms, no effective or curative therapy has been accomplished. In this context, cellular therapy with stem cells (SCs) arises as a new therapeutic approach, with a wide application potential. The -purpose of this study is to evaluate the safety of SCs infusion procedure in patients with advanced COPD (stage IV dyspnea). After selection, patients underwent clinical examination and received granulocyte colony-stimulating factor, immediately prior to the bone marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and infused into a peripheral vein. The 12-month follow-up showed a significant improvement in the quality of life, as well as a clinical stable condition, which suggest a change in the natural process of the disease. Therefore, the proposed methodology in this study for BMMC cell therapy in sufferers of advanced COPD was demonstrated to be free of significant adverse effects. Although a larger sample and a greater follow-up period are needed, it is possible to infer that BMMC cell therapy introduces an unprecedented change in the course or in the natural history of emphysema, inhibiting or slowing the progression of disease. This clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was approved by the Brazilian National Committee of Ethics in Research (registration no. 14764, CONEP report 233/2009).
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2014-05-20T15:34:27Z
2014-05-20T15:34:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2147/COPD.S15292
International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 63-71, 2011.
1176-9106
http://hdl.handle.net/11449/42545
10.2147/COPD.S15292
WOS:000208709800007
WOS000208709800007.pdf
url http://dx.doi.org/10.2147/COPD.S15292
http://hdl.handle.net/11449/42545
identifier_str_mv International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 63-71, 2011.
1176-9106
10.2147/COPD.S15292
WOS:000208709800007
WOS000208709800007.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Chronic Obstructive Pulmonary Disease
1,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 63-71
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press Ltd
publisher.none.fl_str_mv Dove Medical Press Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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