Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/COPD.S15292 http://hdl.handle.net/11449/42545 |
Resumo: | Within the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema presents, as a primarily histopathologic feature, the destruction of pulmonary parenchyma and, accordingly, an increase in the airflow obstruction distal to the terminal bronchiole. Notwithstanding the significant advances in prevention and treatment of symptoms, no effective or curative therapy has been accomplished. In this context, cellular therapy with stem cells (SCs) arises as a new therapeutic approach, with a wide application potential. The -purpose of this study is to evaluate the safety of SCs infusion procedure in patients with advanced COPD (stage IV dyspnea). After selection, patients underwent clinical examination and received granulocyte colony-stimulating factor, immediately prior to the bone marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and infused into a peripheral vein. The 12-month follow-up showed a significant improvement in the quality of life, as well as a clinical stable condition, which suggest a change in the natural process of the disease. Therefore, the proposed methodology in this study for BMMC cell therapy in sufferers of advanced COPD was demonstrated to be free of significant adverse effects. Although a larger sample and a greater follow-up period are needed, it is possible to infer that BMMC cell therapy introduces an unprecedented change in the course or in the natural history of emphysema, inhibiting or slowing the progression of disease. This clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was approved by the Brazilian National Committee of Ethics in Research (registration no. 14764, CONEP report 233/2009). |
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Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysemacell therapychronic obstructive pulmonary disease COPDpulmonary emphysemaBMMCstem cellsWithin the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema presents, as a primarily histopathologic feature, the destruction of pulmonary parenchyma and, accordingly, an increase in the airflow obstruction distal to the terminal bronchiole. Notwithstanding the significant advances in prevention and treatment of symptoms, no effective or curative therapy has been accomplished. In this context, cellular therapy with stem cells (SCs) arises as a new therapeutic approach, with a wide application potential. The -purpose of this study is to evaluate the safety of SCs infusion procedure in patients with advanced COPD (stage IV dyspnea). After selection, patients underwent clinical examination and received granulocyte colony-stimulating factor, immediately prior to the bone marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and infused into a peripheral vein. The 12-month follow-up showed a significant improvement in the quality of life, as well as a clinical stable condition, which suggest a change in the natural process of the disease. Therefore, the proposed methodology in this study for BMMC cell therapy in sufferers of advanced COPD was demonstrated to be free of significant adverse effects. Although a larger sample and a greater follow-up period are needed, it is possible to infer that BMMC cell therapy introduces an unprecedented change in the course or in the natural history of emphysema, inhibiting or slowing the progression of disease. This clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was approved by the Brazilian National Committee of Ethics in Research (registration no. 14764, CONEP report 233/2009).Cardiovascular Disease Institute (IMC, Sao Jose do Rio Preto, SP, Brazil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista UNESP, Assis, SP, BrazilCardiovasc Dis Inst IMC, Sao Jose do Rio Preto, SP, BrazilUSP IPT I, Interunits Biotechnol Post Grad Program, São Paulo, BrazilUniv Estadual Paulista UNESP, Assis, SP, BrazilDove Medical Press LtdUniversidade Estadual Paulista (Unesp)Cardiovasc Dis Inst IMCUniversidade de São Paulo (USP)Ribeiro-Paes, Joao Tadeu [UNESP]Bilaqui, AldemirGreco, Oswaldo T.Ruiz, Milton ArturMarcelino, Monica Y.Stessuk, Talita [UNESP]de Faria, Carolina A.Lago, Mario R.2014-05-20T15:34:27Z2014-05-20T15:34:27Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article63-71application/pdfhttp://dx.doi.org/10.2147/COPD.S15292International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 63-71, 2011.1176-9106http://hdl.handle.net/11449/4254510.2147/COPD.S15292WOS:000208709800007WOS000208709800007.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Chronic Obstructive Pulmonary Disease1,395info:eu-repo/semantics/openAccess2023-09-30T06:04:54Zoai:repositorio.unesp.br:11449/42545Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:34:34.603637Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
title |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
spellingShingle |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema Ribeiro-Paes, Joao Tadeu [UNESP] cell therapy chronic obstructive pulmonary disease COPD pulmonary emphysema BMMC stem cells |
title_short |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
title_full |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
title_fullStr |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
title_full_unstemmed |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
title_sort |
Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema |
author |
Ribeiro-Paes, Joao Tadeu [UNESP] |
author_facet |
Ribeiro-Paes, Joao Tadeu [UNESP] Bilaqui, Aldemir Greco, Oswaldo T. Ruiz, Milton Artur Marcelino, Monica Y. Stessuk, Talita [UNESP] de Faria, Carolina A. Lago, Mario R. |
author_role |
author |
author2 |
Bilaqui, Aldemir Greco, Oswaldo T. Ruiz, Milton Artur Marcelino, Monica Y. Stessuk, Talita [UNESP] de Faria, Carolina A. Lago, Mario R. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Cardiovasc Dis Inst IMC Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ribeiro-Paes, Joao Tadeu [UNESP] Bilaqui, Aldemir Greco, Oswaldo T. Ruiz, Milton Artur Marcelino, Monica Y. Stessuk, Talita [UNESP] de Faria, Carolina A. Lago, Mario R. |
dc.subject.por.fl_str_mv |
cell therapy chronic obstructive pulmonary disease COPD pulmonary emphysema BMMC stem cells |
topic |
cell therapy chronic obstructive pulmonary disease COPD pulmonary emphysema BMMC stem cells |
description |
Within the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema presents, as a primarily histopathologic feature, the destruction of pulmonary parenchyma and, accordingly, an increase in the airflow obstruction distal to the terminal bronchiole. Notwithstanding the significant advances in prevention and treatment of symptoms, no effective or curative therapy has been accomplished. In this context, cellular therapy with stem cells (SCs) arises as a new therapeutic approach, with a wide application potential. The -purpose of this study is to evaluate the safety of SCs infusion procedure in patients with advanced COPD (stage IV dyspnea). After selection, patients underwent clinical examination and received granulocyte colony-stimulating factor, immediately prior to the bone marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and infused into a peripheral vein. The 12-month follow-up showed a significant improvement in the quality of life, as well as a clinical stable condition, which suggest a change in the natural process of the disease. Therefore, the proposed methodology in this study for BMMC cell therapy in sufferers of advanced COPD was demonstrated to be free of significant adverse effects. Although a larger sample and a greater follow-up period are needed, it is possible to infer that BMMC cell therapy introduces an unprecedented change in the course or in the natural history of emphysema, inhibiting or slowing the progression of disease. This clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was approved by the Brazilian National Committee of Ethics in Research (registration no. 14764, CONEP report 233/2009). |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2014-05-20T15:34:27Z 2014-05-20T15:34:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/COPD.S15292 International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 63-71, 2011. 1176-9106 http://hdl.handle.net/11449/42545 10.2147/COPD.S15292 WOS:000208709800007 WOS000208709800007.pdf |
url |
http://dx.doi.org/10.2147/COPD.S15292 http://hdl.handle.net/11449/42545 |
identifier_str_mv |
International Journal of Chronic Obstructive Pulmonary Disease. Albany: Dove Medical Press Ltd, v. 6, p. 63-71, 2011. 1176-9106 10.2147/COPD.S15292 WOS:000208709800007 WOS000208709800007.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Chronic Obstructive Pulmonary Disease 1,395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
63-71 application/pdf |
dc.publisher.none.fl_str_mv |
Dove Medical Press Ltd |
publisher.none.fl_str_mv |
Dove Medical Press Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128249319915520 |