Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2018/1498150 http://hdl.handle.net/11449/164110 |
Resumo: | Information regarding the early effects of obesogenic diets on feeding patterns and behaviors is limited. To improve knowledge regarding the etiology of obesity, young male Wistar rats were submitted to high-fat (HFD) or regular chow diets (RCDs) for 14 days. Various metabolic parameters were continuously measured using metabolic chambers. Total weight gain was similar between groups, but heavier visceral fat depots and reduced weight of livers were found in HFD rats. Total calorie intake was increased while individual feeding bouts were shorter and of higher calorie intake in response to HFD. Ambulatory activity and sleep duration were decreased in HFD rats during passive and active phase, respectively. Acylated and unacylated ghrelin levels were unaltered by the increased calorie intake and the early changes in body composition., is indicates that at this early stage, the orexigenic signal did not adapt to the high-calorie content of HFD. We hereby demonstrate that, although total weight gain is not affected, a short-term obesogenic diet alters body composition, feeding patterns, satiation, ambulatory activity profiles, and behaviours in a young rat model. Moreover, this effect precedes changes in weight gain, obesity, and ensuing metabolic disorders. |
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Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat DietInformation regarding the early effects of obesogenic diets on feeding patterns and behaviors is limited. To improve knowledge regarding the etiology of obesity, young male Wistar rats were submitted to high-fat (HFD) or regular chow diets (RCDs) for 14 days. Various metabolic parameters were continuously measured using metabolic chambers. Total weight gain was similar between groups, but heavier visceral fat depots and reduced weight of livers were found in HFD rats. Total calorie intake was increased while individual feeding bouts were shorter and of higher calorie intake in response to HFD. Ambulatory activity and sleep duration were decreased in HFD rats during passive and active phase, respectively. Acylated and unacylated ghrelin levels were unaltered by the increased calorie intake and the early changes in body composition., is indicates that at this early stage, the orexigenic signal did not adapt to the high-calorie content of HFD. We hereby demonstrate that, although total weight gain is not affected, a short-term obesogenic diet alters body composition, feeding patterns, satiation, ambulatory activity profiles, and behaviours in a young rat model. Moreover, this effect precedes changes in weight gain, obesity, and ensuing metabolic disorders.NSERC Discovery GrantFQRS Chercheur Boursier Junior 1 AwardUniv Quebec Montreal UQAM, Dept Sci Act Phys, 141 President Kennedy Ave, Montreal, PQ H2X 1Y4, CanadaUniv Quebec Montreal, GRAPA, 141 President Kennedy Ave, Montreal, PQ H2X 1Y4, CanadaUniv Quebec Montreal, Dept Sci Biol, 141 President Kennedy Ave, Montreal, PQ H2X 1Y4, CanadaCHU St Justine, Ctr Rech, 3175 Chemin Cote St Catherine, Montreal, PQ H3T 1C5, CanadaSao Paulo State Univ, Dept Phys Educ, BR-19060900 Presidente Prudente, SP, BrazilUniv Virginia, Dept Med, 450 Ray C Hunt Dr, Charlottesville, VA 22903 USARoyal Canadian Mil Coll, 15 Jacques Cartier Nord, St Jean, PQ J3B 8R8, CanadaSao Paulo State Univ, Dept Phys Educ, BR-19060900 Presidente Prudente, SP, BrazilNSERC Discovery Grant: 418509-2012Hindawi LtdUniv Quebec Montreal UQAMUniv Quebec MontrealCHU St JustineUniversidade Estadual Paulista (Unesp)Univ VirginiaRoyal Canadian Mil CollAndrich, David E.Melbouci, LilyaOu, YaLeduc-Gaudet, Jean-PhilippeChabot, FrancoisLalonde, FrancoisLira, Fabio Santos [UNESP]Gaylinn, Bruce D.Gouspillou, GillesDanialou, GawiyouComtois, Alain-SteveSt-Pierre, David H.2018-11-26T17:49:08Z2018-11-26T17:49:08Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://dx.doi.org/10.1155/2018/1498150Journal Of Nutrition And Metabolism. London: Hindawi Ltd, 10 p., 2018.2090-0724http://hdl.handle.net/11449/16411010.1155/2018/1498150WOS:000430284900001WOS000430284900001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Nutrition And Metabolism0,681info:eu-repo/semantics/openAccess2024-06-18T18:18:06Zoai:repositorio.unesp.br:11449/164110Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:59:15.791971Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
title |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
spellingShingle |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet Andrich, David E. |
title_short |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
title_full |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
title_fullStr |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
title_full_unstemmed |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
title_sort |
Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet |
author |
Andrich, David E. |
author_facet |
Andrich, David E. Melbouci, Lilya Ou, Ya Leduc-Gaudet, Jean-Philippe Chabot, Francois Lalonde, Francois Lira, Fabio Santos [UNESP] Gaylinn, Bruce D. Gouspillou, Gilles Danialou, Gawiyou Comtois, Alain-Steve St-Pierre, David H. |
author_role |
author |
author2 |
Melbouci, Lilya Ou, Ya Leduc-Gaudet, Jean-Philippe Chabot, Francois Lalonde, Francois Lira, Fabio Santos [UNESP] Gaylinn, Bruce D. Gouspillou, Gilles Danialou, Gawiyou Comtois, Alain-Steve St-Pierre, David H. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Quebec Montreal UQAM Univ Quebec Montreal CHU St Justine Universidade Estadual Paulista (Unesp) Univ Virginia Royal Canadian Mil Coll |
dc.contributor.author.fl_str_mv |
Andrich, David E. Melbouci, Lilya Ou, Ya Leduc-Gaudet, Jean-Philippe Chabot, Francois Lalonde, Francois Lira, Fabio Santos [UNESP] Gaylinn, Bruce D. Gouspillou, Gilles Danialou, Gawiyou Comtois, Alain-Steve St-Pierre, David H. |
description |
Information regarding the early effects of obesogenic diets on feeding patterns and behaviors is limited. To improve knowledge regarding the etiology of obesity, young male Wistar rats were submitted to high-fat (HFD) or regular chow diets (RCDs) for 14 days. Various metabolic parameters were continuously measured using metabolic chambers. Total weight gain was similar between groups, but heavier visceral fat depots and reduced weight of livers were found in HFD rats. Total calorie intake was increased while individual feeding bouts were shorter and of higher calorie intake in response to HFD. Ambulatory activity and sleep duration were decreased in HFD rats during passive and active phase, respectively. Acylated and unacylated ghrelin levels were unaltered by the increased calorie intake and the early changes in body composition., is indicates that at this early stage, the orexigenic signal did not adapt to the high-calorie content of HFD. We hereby demonstrate that, although total weight gain is not affected, a short-term obesogenic diet alters body composition, feeding patterns, satiation, ambulatory activity profiles, and behaviours in a young rat model. Moreover, this effect precedes changes in weight gain, obesity, and ensuing metabolic disorders. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:49:08Z 2018-11-26T17:49:08Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2018/1498150 Journal Of Nutrition And Metabolism. London: Hindawi Ltd, 10 p., 2018. 2090-0724 http://hdl.handle.net/11449/164110 10.1155/2018/1498150 WOS:000430284900001 WOS000430284900001.pdf |
url |
http://dx.doi.org/10.1155/2018/1498150 http://hdl.handle.net/11449/164110 |
identifier_str_mv |
Journal Of Nutrition And Metabolism. London: Hindawi Ltd, 10 p., 2018. 2090-0724 10.1155/2018/1498150 WOS:000430284900001 WOS000430284900001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Nutrition And Metabolism 0,681 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129008880058368 |