Eficácia 'in vivo' da cefoperazona sódica, gentamcina e ciprofloxacino no tratamento intramamário da mastite clínica bovina

• Main Author: Maiolino, Sérgio Ricardo [UNESP]
• Publication Date: 2014
• Other Authors: Ribeiro, Márcio Garcia [UNESP], Motta, Rodrigo Garcia [UNESP], Silva, Aristeu Vieira da, Maiolino, Glaucea Suman [UNESP], Listoni, Fernando José Paganini [UNESP]
• Format: Article
• Language: por
• Source: Repositório Institucional da UNESP
• Download full: http://www.fmvz.unesp.br/rvz/index.php/rvz/article/view/666; http://hdl.handle.net/11449/140886
• topic: Clinical mastitis in cows; Intramammary treatment; Clinical cure; Bacteriological cure; Antimicrobial sensitivity test; Mastitis clinica bovina; Tratamiento intramamario; Cura clinica; Cura bacteriológica; Perfil de sensibilidad antimicrobiana; Mastite clínica bovina; Tratamento intramamário; Cura clínica; Cura bacteriológica; Perfil de sensibilidade aos antimicrobianos

This study evaluated the in vitro and in vivo efficacy of sodium cefoperazone, gentamicin and ciprofloxacin for the intramammary treatment of clinical mastitis in cows. Thirty cows with non-systemic, clinical mastitis were divided into three groups of ten animals. One of the antibiotics was used in each group for conventional (i.e., three doses, given every 12 hours) and extended (i.e., six doses, every 12 hours) treatments of mastitis. The cows were treated every 12 hours using six doses per animal at the next moments (M): M1, day zero - diagnosis and beginning of treatment; M2, 12 hours from diagnosis and treatment; M3, 24 hours; M4, 36 hours; M5, 48 hours; and M6 60 hours. The most common microorganisms isolated from cows were Staphylococcus aureus, Staphylococcus spp., Corynebacterium sp., Streptococcus spp., Streptococcus agalactiae and Escherichia coli. The efficacy of clinical cure using conventional treatment was 50%, 70% and 50% for the groups treated with sodium cefoperazone, gentamicin and ciprofloxacin, respectively. Regarding the extended treatment, efficacy was 90%, 100% and 80%, for sodium cefoperazone, gentamicin and ciprofloxacin, respectively. Efficacy of bacteriological cure was 100% for sodium cefoperazone, and 90% for both gentamicin and ciprofloxacin using the conventional treatment. By using the extended treatment, efficacy of bacteriological cure was 100% for gentamicin and 90% for both cefoperazone and ciprofloxacin. Statistical differences were not found in clinical or in bacteriological cure into the same group or among groups. Similarly, statistical differences between the conventional and extended treatments were not found. The results from this study reinforce the importance of performing microbiological culture of milk and in vitro antimicrobial sensitivity tests for supporting the intramammary treatment of clinical mastitis in cows. The clinical and bacteriological efficacy of sodium cefoperazone, gentamicin and ciprofloxacin in lactating cows suffering from clinical mastitis using either conventional or extended treatments was also inferred, provided the use of sensitivity tests in vitro.