Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy

Detalhes bibliográficos
Autor(a) principal: Guerra, Renan B. [UNESP]
Data de Publicação: 2016
Outros Autores: Gálico, Diogo A. [UNESP], Holanda, Bruno B. C. [UNESP], Bannach, Gilbert [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10973-015-5228-2
http://hdl.handle.net/11449/172622
Resumo: Simultaneous thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry-optical microscopy (DSC-optical microscopy), online coupled thermogravimetry-infrared spectroscopy evolved gas analyses (TG-EGA-MIR), and spectroscopic techniques were used to study the non-steroidal anti-inflammatory drug sulindac in polymorphic form II. The TG-DSC curves, which were performed with the aid of DSC-optical microscopy, provided information concerning the thermal stability and decomposition profiles of the compound. From the TG-EGA-MIR coupled technique, it was possible to identify formaldehyde as a volatile compound that was released during thermal decomposition. A complete spectroscopic characterization in the ultraviolet, visible, near- and middle-infrared regions was performed in order to understand the spectroscopic properties of sulindac form II.
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spelling Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopyCoupled TG-EGA-MIRDSC-optical microscopySpectroscopic studiesSulindacThermal behaviorSimultaneous thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry-optical microscopy (DSC-optical microscopy), online coupled thermogravimetry-infrared spectroscopy evolved gas analyses (TG-EGA-MIR), and spectroscopic techniques were used to study the non-steroidal anti-inflammatory drug sulindac in polymorphic form II. The TG-DSC curves, which were performed with the aid of DSC-optical microscopy, provided information concerning the thermal stability and decomposition profiles of the compound. From the TG-EGA-MIR coupled technique, it was possible to identify formaldehyde as a volatile compound that was released during thermal decomposition. A complete spectroscopic characterization in the ultraviolet, visible, near- and middle-infrared regions was performed in order to understand the spectroscopic properties of sulindac form II.Faculdade de Ciências Departamento de Química UNESP - Univ. Estadual PaulistaFaculdade de Ciências Departamento de Química UNESP - Univ. Estadual PaulistaUniversidade Estadual Paulista (Unesp)Guerra, Renan B. [UNESP]Gálico, Diogo A. [UNESP]Holanda, Bruno B. C. [UNESP]Bannach, Gilbert [UNESP]2018-12-11T17:01:29Z2018-12-11T17:01:29Z2016-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2523-2530application/pdfhttp://dx.doi.org/10.1007/s10973-015-5228-2Journal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2523-2530, 2016.1588-29261388-6150http://hdl.handle.net/11449/17262210.1007/s10973-015-5228-22-s2.0-849594882012-s2.0-84959488201.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Thermal Analysis and Calorimetry0,5870,587info:eu-repo/semantics/openAccess2024-04-29T18:16:59Zoai:repositorio.unesp.br:11449/172622Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:08:54.116664Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
title Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
spellingShingle Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
Guerra, Renan B. [UNESP]
Coupled TG-EGA-MIR
DSC-optical microscopy
Spectroscopic studies
Sulindac
Thermal behavior
title_short Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
title_full Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
title_fullStr Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
title_full_unstemmed Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
title_sort Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV-Vis, MIR, NIR, DSC, simultaneous TG-DSC, and the coupled techniques TG-EGA-MIR and DSC-optical microscopy
author Guerra, Renan B. [UNESP]
author_facet Guerra, Renan B. [UNESP]
Gálico, Diogo A. [UNESP]
Holanda, Bruno B. C. [UNESP]
Bannach, Gilbert [UNESP]
author_role author
author2 Gálico, Diogo A. [UNESP]
Holanda, Bruno B. C. [UNESP]
Bannach, Gilbert [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Guerra, Renan B. [UNESP]
Gálico, Diogo A. [UNESP]
Holanda, Bruno B. C. [UNESP]
Bannach, Gilbert [UNESP]
dc.subject.por.fl_str_mv Coupled TG-EGA-MIR
DSC-optical microscopy
Spectroscopic studies
Sulindac
Thermal behavior
topic Coupled TG-EGA-MIR
DSC-optical microscopy
Spectroscopic studies
Sulindac
Thermal behavior
description Simultaneous thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry-optical microscopy (DSC-optical microscopy), online coupled thermogravimetry-infrared spectroscopy evolved gas analyses (TG-EGA-MIR), and spectroscopic techniques were used to study the non-steroidal anti-inflammatory drug sulindac in polymorphic form II. The TG-DSC curves, which were performed with the aid of DSC-optical microscopy, provided information concerning the thermal stability and decomposition profiles of the compound. From the TG-EGA-MIR coupled technique, it was possible to identify formaldehyde as a volatile compound that was released during thermal decomposition. A complete spectroscopic characterization in the ultraviolet, visible, near- and middle-infrared regions was performed in order to understand the spectroscopic properties of sulindac form II.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-01
2018-12-11T17:01:29Z
2018-12-11T17:01:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10973-015-5228-2
Journal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2523-2530, 2016.
1588-2926
1388-6150
http://hdl.handle.net/11449/172622
10.1007/s10973-015-5228-2
2-s2.0-84959488201
2-s2.0-84959488201.pdf
url http://dx.doi.org/10.1007/s10973-015-5228-2
http://hdl.handle.net/11449/172622
identifier_str_mv Journal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2523-2530, 2016.
1588-2926
1388-6150
10.1007/s10973-015-5228-2
2-s2.0-84959488201
2-s2.0-84959488201.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Thermal Analysis and Calorimetry
0,587
0,587
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2523-2530
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128761772638208

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