Evolution of vertebrate respiratory central rhythm generators
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.resp.2021.103781 http://hdl.handle.net/11449/222350 |
Resumo: | Tracing the evolution of the central rhythm generators associated with ventilation in vertebrates is hindered by a lack of information surrounding key transitions. To begin with, central rhythm generation has been studied in detail in only a few species from four vertebrate groups, lamprey, anuran amphibians, turtles, and mammals (primarily rodents). Secondly, there is a lack of information regarding the transition from water breathing fish to air breathing amniotes (reptiles, birds, and mammals). Specifically, the respiratory rhythm generators of fish appear to be single oscillators capable of generating both phases of the respiratory cycle (expansion and compression) and projecting to motoneurons in cranial nerves innervating bucco-pharyngeal muscles. In the amniotes we find oscillators capable of independently generating separate phases of the respiratory cycle (expiration and inspiration) and projecting to pre-motoneurons in the ventrolateral medulla that in turn project to spinal motoneurons innervating thoracic and abdominal muscles (reptiles, birds, and mammals). Studies of the one group of amphibians that lie at this transition (the anurans), raise intriguing possibilities but, for a variety of reasons that we explore, also raise unanswered questions. In this review we summarize what is known about the rhythm generating circuits associated with breathing that arise from the different rhombomeric segments in each of the different vertebrate classes. Assuming oscillating circuits form in every pair of rhombomeres in every vertebrate during development, we trace what appears to be the evolutionary fate of each and highlight the questions that remain to be answered to properly understand the evolutionary transitions in vertebrate central respiratory rhythm generation. |
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Evolution of vertebrate respiratory central rhythm generatorsBreathing in vertebratesCentral respiratory rhythm generationControl of breathingEvolutionTracing the evolution of the central rhythm generators associated with ventilation in vertebrates is hindered by a lack of information surrounding key transitions. To begin with, central rhythm generation has been studied in detail in only a few species from four vertebrate groups, lamprey, anuran amphibians, turtles, and mammals (primarily rodents). Secondly, there is a lack of information regarding the transition from water breathing fish to air breathing amniotes (reptiles, birds, and mammals). Specifically, the respiratory rhythm generators of fish appear to be single oscillators capable of generating both phases of the respiratory cycle (expansion and compression) and projecting to motoneurons in cranial nerves innervating bucco-pharyngeal muscles. In the amniotes we find oscillators capable of independently generating separate phases of the respiratory cycle (expiration and inspiration) and projecting to pre-motoneurons in the ventrolateral medulla that in turn project to spinal motoneurons innervating thoracic and abdominal muscles (reptiles, birds, and mammals). Studies of the one group of amphibians that lie at this transition (the anurans), raise intriguing possibilities but, for a variety of reasons that we explore, also raise unanswered questions. In this review we summarize what is known about the rhythm generating circuits associated with breathing that arise from the different rhombomeric segments in each of the different vertebrate classes. Assuming oscillating circuits form in every pair of rhombomeres in every vertebrate during development, we trace what appears to be the evolutionary fate of each and highlight the questions that remain to be answered to properly understand the evolutionary transitions in vertebrate central respiratory rhythm generation.National Science FoundationDepartment of Zoology University of British ColumbiaDépartement de Pédiatrie Université LavalDepartment of Biological Sciences California State UniversityDepartment of Biology University of OttawaDepartamento de Morfologia e Fisiologia Animal UNESPDepartment of Zoophysiology Aarhus UniversityDepartamento de Morfologia e Fisiologia Animal UNESPUniversity of British ColumbiaUniversité LavalCalifornia State UniversityUniversity of OttawaUniversidade Estadual Paulista (UNESP)Aarhus UniversityMilsom, W. K.Kinkead, R.Hedrick, M. S.Gilmour, K.Perry, S.Gargaglioni, L. [UNESP]Wang, T.2022-04-28T19:44:10Z2022-04-28T19:44:10Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.resp.2021.103781Respiratory Physiology and Neurobiology, v. 295.1878-15191569-9048http://hdl.handle.net/11449/22235010.1016/j.resp.2021.1037812-s2.0-85114220455Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRespiratory Physiology and Neurobiologyinfo:eu-repo/semantics/openAccess2022-04-28T19:44:11Zoai:repositorio.unesp.br:11449/222350Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:44:11Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evolution of vertebrate respiratory central rhythm generators |
title |
Evolution of vertebrate respiratory central rhythm generators |
spellingShingle |
Evolution of vertebrate respiratory central rhythm generators Milsom, W. K. Breathing in vertebrates Central respiratory rhythm generation Control of breathing Evolution |
title_short |
Evolution of vertebrate respiratory central rhythm generators |
title_full |
Evolution of vertebrate respiratory central rhythm generators |
title_fullStr |
Evolution of vertebrate respiratory central rhythm generators |
title_full_unstemmed |
Evolution of vertebrate respiratory central rhythm generators |
title_sort |
Evolution of vertebrate respiratory central rhythm generators |
author |
Milsom, W. K. |
author_facet |
Milsom, W. K. Kinkead, R. Hedrick, M. S. Gilmour, K. Perry, S. Gargaglioni, L. [UNESP] Wang, T. |
author_role |
author |
author2 |
Kinkead, R. Hedrick, M. S. Gilmour, K. Perry, S. Gargaglioni, L. [UNESP] Wang, T. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
University of British Columbia Université Laval California State University University of Ottawa Universidade Estadual Paulista (UNESP) Aarhus University |
dc.contributor.author.fl_str_mv |
Milsom, W. K. Kinkead, R. Hedrick, M. S. Gilmour, K. Perry, S. Gargaglioni, L. [UNESP] Wang, T. |
dc.subject.por.fl_str_mv |
Breathing in vertebrates Central respiratory rhythm generation Control of breathing Evolution |
topic |
Breathing in vertebrates Central respiratory rhythm generation Control of breathing Evolution |
description |
Tracing the evolution of the central rhythm generators associated with ventilation in vertebrates is hindered by a lack of information surrounding key transitions. To begin with, central rhythm generation has been studied in detail in only a few species from four vertebrate groups, lamprey, anuran amphibians, turtles, and mammals (primarily rodents). Secondly, there is a lack of information regarding the transition from water breathing fish to air breathing amniotes (reptiles, birds, and mammals). Specifically, the respiratory rhythm generators of fish appear to be single oscillators capable of generating both phases of the respiratory cycle (expansion and compression) and projecting to motoneurons in cranial nerves innervating bucco-pharyngeal muscles. In the amniotes we find oscillators capable of independently generating separate phases of the respiratory cycle (expiration and inspiration) and projecting to pre-motoneurons in the ventrolateral medulla that in turn project to spinal motoneurons innervating thoracic and abdominal muscles (reptiles, birds, and mammals). Studies of the one group of amphibians that lie at this transition (the anurans), raise intriguing possibilities but, for a variety of reasons that we explore, also raise unanswered questions. In this review we summarize what is known about the rhythm generating circuits associated with breathing that arise from the different rhombomeric segments in each of the different vertebrate classes. Assuming oscillating circuits form in every pair of rhombomeres in every vertebrate during development, we trace what appears to be the evolutionary fate of each and highlight the questions that remain to be answered to properly understand the evolutionary transitions in vertebrate central respiratory rhythm generation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:44:10Z 2022-04-28T19:44:10Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.resp.2021.103781 Respiratory Physiology and Neurobiology, v. 295. 1878-1519 1569-9048 http://hdl.handle.net/11449/222350 10.1016/j.resp.2021.103781 2-s2.0-85114220455 |
url |
http://dx.doi.org/10.1016/j.resp.2021.103781 http://hdl.handle.net/11449/222350 |
identifier_str_mv |
Respiratory Physiology and Neurobiology, v. 295. 1878-1519 1569-9048 10.1016/j.resp.2021.103781 2-s2.0-85114220455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Respiratory Physiology and Neurobiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789976673386496 |